Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

(2021) You Xu et al.   Pharmaceutics

Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review

(2020) Anna Lechanteur et al.   Pharmaceutics

Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease

(2020) Dan Mei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mist begins to clear for lung delivery of RNA

(2020) Catherine Shaffer   NATURE BIOTECHNOLOGY

On the particle formation of leucine in spray drying of inhalable microparticles

(2020) Mani Ordoubadi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

(2019) Manon A.A. Jansen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

(2019) Kaushik Thanki et al.   JOURNAL OF CONTROLLED RELEASE

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

(2019) Cypriane Dormenval et al.   PHARMACEUTICAL RESEARCH

Amino acids as stabilizers for spray-dried simvastatin powder for inhalation

(2019) Wangding Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus

(2018) Yoshita Bhide et al.   DRUG DELIVERY

Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology

(2018) Alessandro Fioni et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation

(2018) Sharad Mangal et al.   PHARMACEUTICAL RESEARCH

A novel method for studying airway hyperresponsiveness in allergic guinea pigs in vivo using the PreciseInhale system for delivery of dry powder aerosols

(2018) A. J. Lexmond et al.   Drug Delivery and Translational Research

Development of porous particles using dextran as an excipient for enhanced deep lung delivery of rifampicin

(2018) Kazunori Kadota et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

(2018) Aneesh Thakur et al.   Frontiers in Immunology

Engineering of small interfering RNA-loaded lipidoid-poly( DL -lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

(2017) Kaushik Thanki et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA

(2017) M Choi et al.   GENE THERAPY

Fundamental Investigation of the Drying of Solid Suspensions

(2017) Abdulkadir Osman et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

l -Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders

(2016) Liang Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations

(2015) Sharad Mangal et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Emerging inhalation aerosol devices and strategies: Where are we headed?

(2014) Qi (Tony) Zhou et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro evaluation of the DP-4M PennCentury™ insufflator

(2014) M. Hoppentocht et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals

(2014) Wouter F. Tonnis et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nano spray-dried pyrazinamide-l-leucine dry powders, physical properties and feasibility used as dry powder aerosols

(2014) Kanogwan Kaewjan et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

New anti-inflammatory targets for chronic obstructive pulmonary disease

(2013) Peter J. Barnes   NATURE REVIEWS DRUG DISCOVERY

Dry Powder Inhalation Exposures of the Endotracheally Intubated Rat Lung, Ex Vivo and In Vivo: The Pulmonary Pharmacokinetics of Fluticasone Furoate

(2012) Ewa Selg et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery – A review for multidisciplinary researchers

(2012) Nazrul Islam et al.   MEDICAL ENGINEERING & PHYSICS

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

(2011) Ditte Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Controlled Release Pulmonary Administration of Curcumin Using Swellable Biocompatible Microparticles

(2011) Ibrahim M. El-Sherbiny et al.   MOLECULAR PHARMACEUTICS

Comparison of the viscosity of trehalose and sucrose solutions at various temperatures: Effect of guar gum addition

(2010) M.V. Galmarini et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler

(2008) Kewu Zhu et al.   JOURNAL OF AEROSOL SCIENCE