An Updated Model of the Divisome: Regulation of the Septal Peptidoglycan Synthesis Machinery by the Divisome

Identification of the potential active site of the septal peptidoglycan polymerase FtsW

(2022) Ying Li et al.   PLoS Genetics

A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW

(2021) Xinxing Yang et al.   Nature Microbiology

When the metabolism meets the cell cycle in bacteria

(2021) François Beaufay et al.   CURRENT OPINION IN MICROBIOLOGY

Regulation and function of class A Penicillin-binding proteins

(2021) Manuel Pazos et al.   CURRENT OPINION IN MICROBIOLOGY

Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes

(2021) Ying Li et al.   PLoS Genetics

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

FtsA acts through FtsW to promote cell wall synthesis during cell division in Escherichia coli

(2021) Kyung-Tae Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The coiled-coil domain of Escherichia coli FtsLB is a structurally detuned element critical for modulating its activation in bacterial cell division

(2021) Samuel J. Craven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects

(2020) Antoine Vigouroux et al.   eLife

Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex

(2020) Megan Sjodt et al.   Nature Microbiology

Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis

(2020) Shishen Du et al.   mBio

Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain

(2020) Jonathan Cook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase

(2020) Lindsey S. Marmont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b

(2020) Adrien Boes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role for FtsL in Activation of Septal Peptidoglycan Synthesis

(2020) Kyung-Tae Park et al.   mBio

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN

(2019) Adrien Boes et al.   mBio

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

(2019) Atsushi Taguchi et al.   Nature Microbiology

Movement dynamics of divisome proteins and PBP2x:FtsW in cells of Streptococcus pneumoniae

(2019) Amilcar J. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the DedD Protein in Escherichia coli Cell Constriction

(2019) Bing Liu et al.   JOURNAL OF BACTERIOLOGY

SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

(2019) Nathalie T. Reichmann et al.   Nature Microbiology

How Fts EX localizes to the Z ring and interacts with FtsA to regulate cell division

(2019) Shishen Du et al.   MOLECULAR MICROBIOLOGY

Lytic transglycosylases RlpA and MltC assist in Vibrio cholerae daughter cell separation

(2019) Anna I. Weaver et al.   MOLECULAR MICROBIOLOGY

Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division

(2019) Martín Alcorlo et al.   Nature Communications

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

(2018) Megan Sjodt et al.   NATURE

Disruption of divisome assembly rescued by FtsN–FtsA interaction inEscherichia coli

(2018) Sebastien Pichoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell morphology

(2018) Robert D. Turner et al.   Nature Communications

FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli

(2018) Xiaolong Liu et al.   MOLECULAR MICROBIOLOGY

Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB

(2018) Danguole Kureisaite-Ciziene et al.   mBio

Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli

(2018) Alison M. Berezuk et al.   Scientific Reports

Structural Insights into the FtsQ/FtsB/FtsL Complex, a Key Component of the Divisome

(2018) Yuri Choi et al.   Scientific Reports

PBP1B Glycosyltransferase and Transpeptidase Activities Play Different Essential Roles during the De Novo Regeneration of Rod Morphology in Escherichia coli

(2017) Dev K. Ranjit et al.   JOURNAL OF BACTERIOLOGY

The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions

(2017) Samson G. F. Condon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial separation of FtsZ and FtsN during cell division

(2017) Bill Söderström et al.   MOLECULAR MICROBIOLOGY

GTPase activity–coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis

(2017) Xinxing Yang et al.   SCIENCE

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

(2017) Alexandre W. Bisson-Filho et al.   SCIENCE

A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

(2017) Paramita Sarkar et al.   MedChemComm

Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments

(2017) Marcin Krupka et al.   Nature Communications

NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli

(2017) Mary-Jane Tsang et al.   PLoS Genetics

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

(2017) Sophie Leclercq et al.   Scientific Reports

SEDS proteins are a widespread family of bacterial cell wall polymerases

(2016) Alexander J. Meeske et al.   NATURE

A role for the FtsQLB complex in cytokinetic ring activation revealed by anftsLallele that accelerates division

(2015) Mary-Jane Tsang et al.   MOLECULAR MICROBIOLOGY

Roles for both FtsA and the FtsBLQ subcomplex in FtsN-stimulated cell constriction inEscherichia coli

(2015) Bing Liu et al.   MOLECULAR MICROBIOLOGY

The stoichiometric divisome: a hypothesis

(2015) Alexander J. F. Egan et al.   Frontiers in Microbiology

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation inPseudomonas aeruginosa

(2014) Matthew A. Jorgenson et al.   MOLECULAR MICROBIOLOGY

A role for FtsA in SPOR-independent localization of the essentialEscherichia colicell division protein FtsN

(2014) Kimberly K. Busiek et al.   MOLECULAR MICROBIOLOGY

Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli

(2014) Eric Sauvage et al.   PLoS One

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

(2014) A. J. F. Egan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coli Peptidoglycan Structure and Mechanics as Predicted by Atomic-Scale Simulations

(2014) James C. Gumbart et al.   PLoS Computational Biology

Essential and non-essential interactions in interactome networks: theEscherichia colidivision proteins FtsQ-FtsN interaction

(2013) L. Grenga et al.   ENVIRONMENTAL MICROBIOLOGY

Identification of SPOR Domain Amino Acids Important for Septal Localization, Peptidoglycan Binding, and a Disulfide Bond in the Cell Division Protein FtsN

(2013) T. R. Duncan et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

(2013) B. C. Chung et al.   SCIENCE

The N-Terminal Membrane-Spanning Domain of the Escherichia coli DNA Translocase FtsK Hexamerizes at Midcell

(2013) P. Bisicchia et al.   mBio

FtsA forms actin-like protofilaments

(2012) Piotr Szwedziak et al.   EMBO JOURNAL

The Early Divisome Protein FtsA Interacts Directly through Its 1c Subdomain with the Cytoplasmic Domain of the Late Divisome Protein FtsN

(2012) K. K. Busiek et al.   JOURNAL OF BACTERIOLOGY

More than just lysins: peptidoglycan hydrolases tailor the cell wall

(2011) Tsuyoshi Uehara et al.   CURRENT OPINION IN MICROBIOLOGY

Role of Leucine Zipper Motifs in Association of the Escherichia coli Cell Division Proteins FtsL and FtsB

(2011) C. Robichon et al.   JOURNAL OF BACTERIOLOGY

FtsA mutants impaired for self-interaction bypass ZipA suggesting a model in which FtsA's self-interaction competes with its ability to recruit downstream division proteins

(2011) Sebastien Pichoff et al.   MOLECULAR MICROBIOLOGY

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

(2011) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Multiple Interaction Domains in FtsL, a Protein Component of the Widely Conserved Bacterial FtsLBQ Cell Division Complex

(2010) M. D. Gonzalez et al.   JOURNAL OF BACTERIOLOGY

The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli

(2010) C. Fraipont et al.   MICROBIOLOGY-SGM

Direct interactions of early and late assembling division proteins in Escherichia coli cells resolved by FRET

(2010) Svetlana Alexeeva et al.   MOLECULAR MICROBIOLOGY

Positioning cell wall synthetic complexes by the bacterial morphogenetic proteins MreB and MreD

(2010) Courtney L. White et al.   MOLECULAR MICROBIOLOGY

Self-Enhanced Accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR Domain (DamX, DedD, and RlpA) in Escherichia coli Cell Constriction

(2009) M. A. Gerding et al.   JOURNAL OF BACTERIOLOGY

Discovery and Characterization of Three New Escherichia coli Septal Ring Proteins That Contain a SPOR Domain: DamX, DedD, and RlpA

(2009) S. J. R. Arends et al.   JOURNAL OF BACTERIOLOGY

Divisome under Construction: Distinct Domains of the Small Membrane Protein FtsB Are Necessary for Interaction with Multiple Cell Division Proteins

(2009) M. D. Gonzalez et al.   JOURNAL OF BACTERIOLOGY

Two-Step Assembly Dynamics of the Bacillus subtilis Divisome

(2009) P. Gamba et al.   JOURNAL OF BACTERIOLOGY

Metabolism, cell growth and the bacterial cell cycle

(2009) Jue D. Wang et al.   NATURE REVIEWS MICROBIOLOGY

Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli

(2009) M.-T. Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth of Escherichia coli: Significance of Peptidoglycan Degradation during Elongation and Septation

(2008) T. Uehara et al.   JOURNAL OF BACTERIOLOGY

Structural and mutational analysis of the cell division protein FtsQ

(2008) Fusinita van den Ent et al.   MOLECULAR MICROBIOLOGY