Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

(2022) Laura Vangeel et al.   ANTIVIRAL RESEARCH

Review on molnupiravir as a promising oral drug for the treatment of COVID-19

(2022) Elham Zarenezhad et al.   MEDICINAL CHEMISTRY RESEARCH

Active pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches

(2022) Vinod Kumar et al.   Bioengineered

Environmental Assessment of Enzyme Production and Purification

(2021) Martin Becker et al.   MOLECULES

Production of myo ‐inositol: Recent advance and prospective

(2021) Yunjie Li et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?

(2021) Athanasios-Dimitrios Bakasis et al.   Cells

A Multi-Enzyme Cascade Reaction for the Production of 2′3′-cGAMP

(2021) Martin Becker et al.   Biomolecules

Streamlining Design, Engineering, and Applications of Enzymes for Sustainable Biocatalysis

(2021) Roger A. Sheldon et al.   ACS Sustainable Chemistry & Engineering

Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

(2021) George R Painter et al.   Current Opinion in Virology

Getting the Most Out of Enzyme Cascades: Strategies to Optimize In Vitro Multi-Enzymatic Reactions

(2021) Regine Siedentop et al.   Catalysts

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

(2021) John A. McIntosh et al.   ACS Central Science

Molnupiravir in COVID-19: A systematic review of literature

(2021) Awadhesh Kumar Singh et al.   Diabetes & Metabolic Syndrome-Clinical Research & Reviews

A Multi-Enzymatic Cascade Reaction for the Synthesis of Vidarabine 5′-Monophosphate

(2020) Marina Simona Robescu et al.   Catalysts

A Glimpse into Green Chemistry Practices in the Pharmaceutical Industry

(2020) Sudripet Sharma et al.   ChemSusChem

Efficient production of myo-inositol in Escherichia coli through metabolic engineering

(2020) Ran You et al.   Microbial Cell Factories

Gaining insight into irrational off‐label use of vidarabine through analysis of a spontaneous reporting system in China

(2020) Haona Li et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone

(2020) Niki R. Patel et al.   ORGANIC LETTERS

Advances in the research on the targets of anti-malaria actions of artemisinin

(2020) Jing Yang et al.   PHARMACOLOGY & THERAPEUTICS

Design of enzymatic cascade processes for the production of low-priced chemicals

(2019) Angela Viviana Ruales-Salcedo et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Energising the E-factor: The E+-factor

(2019) Florian Tieves et al.   TETRAHEDRON

Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges

(2019) Rory M. Shallis et al.   BLOOD REVIEWS

Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC

(2019) Todd M. Bauer et al.   Journal of Thoracic Oncology

Recombinant Proteins for Industrial versus Pharmaceutical Purposes: A Review of Process and Pricing

(2019) John Puetz et al.   Processes

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

(2019) Markus Schober et al.   Nature Catalysis

Bioactive modulators targeting STING adaptor in cGAS-STING pathway

(2019) Xi Feng et al.   DRUG DISCOVERY TODAY

A critical comparison of cellular and cell-free bioproduction systems

(2019) Nico J Claassens et al.   CURRENT OPINION IN BIOTECHNOLOGY

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

(2019) Yuan Fang et al.   Journal of Hematology & Oncology

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Biocatalysis for synthesis of pharmaceuticals

(2018) Ramesh N. Patel   BIOORGANIC & MEDICINAL CHEMISTRY

Techno-economic analysis of the industrial production of a low-cost enzyme using E. coli: the case of recombinant β-glucosidase

(2018) Rafael da Gama Ferreira et al.   Biotechnology for Biofuels

Continuous flow biocatalysis

(2018) Joshua Britton et al.   CHEMICAL SOCIETY REVIEWS

Production of myo-inositol from glucose by a novel trienzymatic cascade of polyphosphate glucokinase, inositol 1-phosphate synthase and inositol monophosphatase

(2018) Yiping Lu et al.   ENZYME AND MICROBIAL TECHNOLOGY

Four self-sufficient biocascades for all 4-methoxyphenyl-1,2-propanediol isomers with product crystallization targeting atom efficiency and excellent E-factors

(2018) Reinhard Oeggl et al.   ACS Sustainable Chemistry & Engineering

Stoichiometric Conversion of Cellulosic Biomass by in Vitro Synthetic Enzymatic Biosystems for Biomanufacturing

(2018) Dongdong Meng et al.   ACS Catalysis

LBA15Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas

(2018) K J Harrington et al.   ANNALS OF ONCOLOGY

Upgrade of wood sugar d-xylose to a value-added nutraceutical by in vitro metabolic engineering

(2018) Kun Cheng et al.   METABOLIC ENGINEERING

The E factor 25 years on: the rise of green chemistry and sustainability

(2017) Roger A. Sheldon   GREEN CHEMISTRY

Life cycle assessment of β-Galactosidase enzyme production

(2017) S. Feijoo et al.   JOURNAL OF CLEANER PRODUCTION

Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

(2017) Mark McLaughlin et al.   ORGANIC LETTERS

Thermal Cycling Cascade Biocatalysis of myo-Inositol Synthesis from Sucrose

(2017) Chao Zhong et al.   ACS Catalysis

In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production

(2017) Xixian Chen et al.   ACS Synthetic Biology

A Review of Biotechnological Artemisinin Production in Plants

(2017) Nur K. B. K. Ikram et al.   Frontiers in Plant Science

Synthetic biology’s first malaria drug meets market resistance

(2016) Mark Peplow   NATURE

Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials

(2016) Vittorio Unfer et al.   International Journal of Endocrinology

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Synthesis of EFdA via a Diastereoselective Aldol Reaction of a Protected 3-Keto Furanose

(2015) Kei Fukuyama et al.   ORGANIC LETTERS

Redesigning the synthesis of vidarabine via a multienzymatic reaction catalyzed by immobilized nucleoside phosphorylases

(2015) Immacolata Serra et al.   RSC Advances

Concise Synthesis of the Anti-HIV Nucleoside EFdA

(2015) Masayuki KAGEYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A two-step biocatalytic cascade in micro-aqueous medium: using whole cells to obtain high concentrations of a vicinal diol

(2014) Andre Jakoblinnert et al.   GREEN CHEMISTRY

Bioretrosynthetic construction of a didanosine biosynthetic pathway

(2014) William R Birmingham et al.   Nature Chemical Biology

One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

(2013) Joerg H. Schrittwieser et al.   GREEN CHEMISTRY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

(2013) Xixian Chen et al.   PLoS One

Environmental assessment of enzyme use in industrial production – a literature review

(2012) Kenthorai Raman Jegannathan et al.   JOURNAL OF CLEANER PRODUCTION

Enantioselective Total Synthesis of the Potent Anti-HIV Nucleoside EFdA

(2011) Masayuki Kageyama et al.   ORGANIC LETTERS

E factors, green chemistry and catalysis: an odyssey

(2008) Roger A. Sheldon   CHEMICAL COMMUNICATIONS

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE