Article
Food Science & Technology
Wei-Jyun Chien, Dinar S. Saputri, Hung-Yu Lin
Summary: This study utilized ultrasonication to extract flavonoids from citrus peels and found that solvent type, fruit maturity, and extraction period significantly affect the flavonoid yield. Unripe fruits and extraction with ethanol solvent showed higher flavonoid content. Dominant compounds included nobiletin, tangeretin, and rutin. Further research is needed to explore other bioactivities of these flavonoids.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ryunosuke Mitani, Hiroyuki Tashiro, Eito Arita, Kento Ono, Masashi Haraguchi, Shinichi Tokunaga, Tanjina Sharmin, Taku Michael Aida, Kenji Mishima
Summary: Extraction of nobiletin and tangeretin from Citrus poonensis peels using liquid CO2 with ethanol entrainer resulted in higher yields compared to conventional ethanol extraction, with similar DPPH radical scavenging activity to ascorbic acid and alpha-tocopherol.
SEPARATION SCIENCE AND TECHNOLOGY
(2021)
Review
Food Science & Technology
Rizwan Arshad, Saira Masood, Hafiz Rizwan Sharif, Gulden Goksen, Baojun Xu, Muhammad Faisal Manzoor
Summary: Nobiletin (NOB), a natural active ingredient belonging to the citrus family, has potential as an antioxidative, anti-inflammatory, anti-neurodegenerative, and anti-viral agent. Enhancing its solubility and bioavailability is of current interest. Multiple studies cover the therapeutic benefits of NOB against different diseases, but a comprehensive review of its chemistry, metabolism, and curative abilities is lacking.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
C. Y. Chen, J. J. Wang, C. L. Kao, H. C. Yeh, P. L. Song, S. L. Liu, H. M. Wu, H. T. Li, W. J. Li
Summary: A new flavanone, 5-hydroxy-7,2 ',3 ',4 ',5 ',6 '-hexamethoxyflavanone (1), was isolated from the unripe fruit peels of Citrus reticulata (Rutaceae), along with two known polymethoxyflavones. The structure of compound 1 was characterized and identified by spectral analysis.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Gael N. N. Neba Ambe, Carlo Breda, Avninder Singh Bhambra, Randolph R. J. Arroo
Summary: The importance of the circadian clock in maintaining human health is widely recognized. Dysregulated and dampened clocks may contribute to age-related diseases and metabolic syndrome. This review explores dietary compounds that have a positive impact on the circadian clock, particularly nobiletin, which shows promise as a chronotherapeutic agent.
Article
Integrative & Complementary Medicine
Ningfang Zhang, Wenqi Wu, Yapeng Huang, Lingyue An, Zhichan He, Zhenglin Chang, Zhaohui He, Yongchang Lai
Summary: This study explored the effects of tangeretin, an active ingredient from orange peel, on castration-resistant prostate cancer (CRPC) cells. The results showed that tangeretin can inhibit the proliferation and migration of CRPC cells, and improve their sensitivity to anti-tumor drugs. Additionally, tangeretin also affected the expression of several signaling pathways involved in cancer progression.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Haruki Ito, Hiromitsu Negoro, Jin Kono, Naoki Hayata, Takayoshi Miura, Yumi Manabe, Yu Miyazaki, Mutsuki Mishina, Je Tae Woo, Naoki Sakane, Hiroshi Okuno
Summary: This study investigated the efficacy of Nobiletin and tangeretin for treating nocturia. The results showed that these flavonoids had little effect on nocturnal bladder capacity but reduced nighttime frequency and nocturnal polyuria index.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Jiali Huang, Yu-Jing Lu, Chenglong Guo, Shanshan Zuo, Jin-Lin Zhou, Wing-Leung Wong, Baohua Huang
Summary: Twelve citrus flavonoids were found to inhibit the bitter taste of naringin, quinine hydrochloride, and stevioside, with neohesperidin dihydrochalcone (NHDC) and neodiosmin showing excellent bitterness inhibition effects. Structure-activity relationship analysis indicated that the 7-linked neohesperidosyloxy group in the A-ring of the citrus flavonoid skeleton had the best bitterness inhibition effect.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Agriculture, Multidisciplinary
Gang Ma, Lancui Zhang, Mao Seoka, Akari Nakata, Masaki Yahata, Takehiko Shimada, Hiroshi Fujii, Tomoko Endo, Terutaka Yoshioka, Toshiyuki Kan, Masaya Kato
Summary: Citrus fruits with high levels of nobiletin accumulation showed high expression of CitOMT2, while fruits with low levels of nobiletin had low expression of CitOMT2. Functional analysis revealed that CitOMT2 acts as a caffeic acid 8-O-methyltransferase, playing a crucial role in nobiletin biosynthesis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xue Rong, Jie Xu, Yang Jiang, Feng Li, Yilun Chen, Q. Ping Dou, Dapeng Li
Summary: Nobiletin enhances autophagy through activating the IL-6/STAT3/FOXO3a pathway in macrophage cells, leading to suppression of inflammatory response.
Article
Biochemistry & Molecular Biology
Daniel Mamy, Yuanyuan Huang, Nelson Dzidzorgbe Kwaku Akpabli-Tsigbe, Maurizio Battino, Xiumin Chen
Summary: This study demonstrated that the bioactive components and antioxidant activities of citrus peel powder can be significantly enhanced through solid-state fermentation with Aspergillus niger CGMCC3.6189. Optimal fermentation conditions resulted in a substantial increase in flavonoid accumulation and antioxidant activity in CRPP, but prolonged fermentation time led to increased darkness in color. This research provides a feasible and effective method to improve the bioactivity of citrus peel powder for potential applications in the food, nutraceutical, and medicinal industries.
Review
Chemistry, Applied
Marina Russo, Francesca Rigano, Adriana Arigo, Paola Dugo, Luigi Mondello
Summary: Cold-pressed citrus essential oils, such as lemon, bergamot, lime, grapefruit, mandarin, sweet and bitter orange, are commonly used in food, cosmetic, and pharmaceutical industries. However, the extraction processes are costly with low yields, leading to frequent adulteration, requiring careful attention to ensure authenticity. Additionally, psoralen levels are continuously monitored due to their photoactivity.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Jiajing Chen, Gu Li, Haipeng Zhang, Ziyu Yuan, Wenyun Li, Zhaoxin Peng, Meiyan Shi, Wenyu Ding, Huixian Zhang, Yunjiang Cheng, Jia-Long Yao, Juan Xu
Summary: The study found a close correlation between the bitterness of citrus fruits and the presence of the 1,2RhaT gene, with pummelo identified as the genetic origin for FNH bitterness in modern citrus cultivars. Furthermore, certain transcription factor genes were shown to coexpress with genes related to FNH accumulation, potentially affecting the taste of citrus fruits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Taisuke Murata, Sho Ishiwa, Xin Lin, Yosuke Nakazawa, Kenji Tago, Megumi Funakoshi-Tago
Summary: Nobiletin, a flavonoid found in shikuwasa, has been shown to have anti-inflammatory effects by inhibiting the production of inflammatory substances and reducing neuroinflammation in mice. These findings suggest that nobiletin could be a potential drug for preventing neuroinflammation.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Akiko Nakamoto, Yuwa Hirabayashi, Chieri Anzaki, Mariko Nakamoto, Emi Shuto, Tohru Sakai
Summary: This study investigated the impact of nobiletin on the disease state and immune responses in experimental autoimmune encephalomyelitis mice. The findings suggest that nobiletin significantly reduced clinical scores and interleukin-17A production in splenocytes. In vitro analysis also showed that nobiletin suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)