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Coumarins, Psoralens and Polymethoxyflavones in Cold-pressed Citrus Essential Oils: a Review

Journal

JOURNAL OF ESSENTIAL OIL RESEARCH
Volume 33, Issue 3, Pages 221-239

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/10412905.2020.1857855

Keywords

Coumarin; psoralen; polymethoxyflavone; citrus; essential oil; HPLC

Funding

  1. Merck Life Science Corporations

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Cold-pressed citrus essential oils, such as lemon, bergamot, lime, grapefruit, mandarin, sweet and bitter orange, are commonly used in food, cosmetic, and pharmaceutical industries. However, the extraction processes are costly with low yields, leading to frequent adulteration, requiring careful attention to ensure authenticity. Additionally, psoralen levels are continuously monitored due to their photoactivity.
Cold-pressed Citrus essential oils namely lemon, bergamot, lime, grapefruit, mandarin, sweet and bitter orange are obtained from the peel of Citrus fruits. They were normally used in food, cosmetic, and pharmaceutical industries as ingredients. Essential oils extraction processes produce oils with different sensory qualities, and often these processes are expensive and have a low yield. For such a reason adulteration process are frequent, so careful attention must be paid to ensure the oils' genuineness and authenticity. Moreover, psoralen levels are continuously monitored by opinions and regulations released from International Fragrance Association and the European Parliament due to their photoactivity. This review aims to browse the scientific literature of the past 30 years on the characterization of the non-volatile fraction of cold-pressed Citrus essential oils to discuss results achieved so far and highlight future prospect.

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