Does Bisphenol A Confer Risk of Neurodevelopmental Disorders? What We Have Learned from Developmental Neurotoxicity Studies in Animal Models

Bisphenol a affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster

(2022) Chloe Welch et al.   NEUROTOXICOLOGY

Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition

(2021) Ping C. Mamiya et al.   Brain Sciences

Endocrine-disrupting chemicals and behaviour: a high risk to take?

(2021) Ioannis Bakoyiannis et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

(2021) Machiko Minatoya et al.   International Journal of Environmental Research and Public Health

Comparative Neurodevelopment Effects of Bisphenol A and Bisphenol F on Rat Fetal Neural Stem Cell Models

(2021) Santokh Gill et al.   Cells

Maternal Bisphenol A (BPA) Exposure Alters Cerebral Cortical Morphogenesis and Synaptic Function in Mice

(2021) Chang Youn Lee et al.   CEREBRAL CORTEX

Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD+-Dependent Deacetylase Sirtuin1 in Lactating and Weaned Rats

(2021) Antonietta Santoro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-Up Adult Hippocampal Neurons

(2021) Suguru Kawato et al.   Frontiers in Neuroscience

Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster

(2021) Elize Aparecida Santos Musachio et al.   FOOD AND CHEMICAL TOXICOLOGY

Roles of ERRα and TGF‑β signaling in stemness enhancement induced by 1 µM bisphenol A exposure via human neural stem cells

(2021) Panpan Dong et al.   Experimental and Therapeutic Medicine

Bisphenol-A Exposure during Gestation and Lactation Causes Visual Perception Deficits in Rat Pups Following a Decrease in Interleukin 1β Expression in the Primary Visual Cortex

(2020) Fan Hu et al.   NEUROSCIENCE

Impairment of learning and memory induced by perinatal exposure to BPA is associated with ERα-mediated alterations of synaptic plasticity and PKC/ERK/CREB signaling pathway in offspring rats

(2020) Dan Wu et al.   BRAIN RESEARCH BULLETIN

Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

(2020) Vicente Mustieles et al.   Environmental Health

Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells

(2020) Zhihong Yin et al.   TOXICOLOGY IN VITRO

Exposure to bisphenol A differentially impacts neurodevelopment and behavior in Drosophila melanogaster from distinct genetic backgrounds

(2020) U. Nguyen et al.   NEUROTOXICOLOGY

The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis

(2020) Pedro M. Rodríguez Cruz et al.   Frontiers in Molecular Neuroscience

Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos

(2019) Pål A. Olsvik et al.   Frontiers in Genetics

Synapse Formation: From Cellular and Molecular Mechanisms to Neurodevelopmental and Neurodegenerative Disorders

(2019) Shadab Batool et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuro-toxic and reproductive effects of BPA

(2019) Antonietta Santoro et al.   Current Neuropharmacology

Effects of environmental chemicals on the proliferation and differentiation of neural stem cells

(2019) Min Huang et al.   ENVIRONMENTAL TOXICOLOGY

Prevalence and Trends of Developmental Disabilities among Children in the United States: 2009–2017

(2019) Benjamin Zablotsky et al.   PEDIATRICS

Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior

(2019) Dinushan Nesan et al.   Annual Review of Physiology

Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

(2019) Melody N. Grohs et al.   Environmental Health

Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length

(2019) Xiaoxing Liang et al.   FOOD AND CHEMICAL TOXICOLOGY

Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China

(2018) Yanru Li et al.   ENVIRONMENTAL POLLUTION

Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction

(2018) Frances Xin et al.   HORMONES AND BEHAVIOR

Impairment of learning and memory performances induced by BPA: Evidences from the literature of a MoA mediated through an ED

(2018) Sakina Mhaouty-Kodja et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish

(2018) Jessica R. Morrice et al.   Scientific Reports

Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

(2018) Robert S. Eisinger et al.   Frontiers in Neuroscience

The Effects of Low-Dose Bisphenol A and Bisphenol F on Neural Differentiation of a Fetal Brain-Derived Neural Progenitor Cell Line

(2018) Yuki Fujiwara et al.   Frontiers in Endocrinology

Factors that influence adult neurogenesis as potential therapy

(2018) Belal Shohayeb et al.   Translational Neurodegeneration

Sensitive neurotoxicity assessment of bisphenol A using double immunocytochemistry of DCX and MAP2

(2018) Jung-Hyun Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Bisphenol A: Food Exposure and Impact on Human Health

(2018) Susana Almeida et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Effects of adolescent Bisphenol-A exposure on memory and spine density in ovariectomized female rats: Adolescence vs adulthood

(2018) Rachel E. Bowman et al.   HORMONES AND BEHAVIOR

Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort

(2018) Tina Kold Jensen et al.   ENVIRONMENTAL RESEARCH

Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability

(2017) Shaina L. Stacy et al.   ENVIRONMENT INTERNATIONAL

Dendritic spines: Morphological building blocks of memory

(2017) Menahem Segal   NEUROBIOLOGY OF LEARNING AND MEMORY

Prenatal phenolic compounds exposure and neurobehavioral development at 2 and 7 years of age

(2017) Ching-Chun Lin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Anxiety like behavior due to perinatal exposure to Bisphenol-A is associated with decrease in excitatory to inhibitory synaptic density of male mouse brain

(2017) Dhiraj Kumar et al.   TOXICOLOGY

Environmental Exposure to Dioxins, Dibenzofurans, Bisphenol A, and Phthalates in Children with and without Autism Spectrum Disorder Living near the Gulf of Mexico

(2017) Mohammad Rahbar et al.   International Journal of Environmental Research and Public Health

Bisphenol A Impairs Synaptic Plasticity by Both Pre- and Postsynaptic Mechanisms

(2017) Fan Hu et al.   Advanced Science

Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a

(2017) Dong Sun et al.   PLoS One

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells

(2017) Sabrina Villar-Pazos et al.   Scientific Reports

Association of Bisphenol A exposure and Attention-Deficit/Hyperactivity Disorder in a national sample of U.S. children

(2016) Shruti Tewar et al.   ENVIRONMENTAL RESEARCH

Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10–12 years of age

(2016) Frederica Perera et al.   ENVIRONMENTAL RESEARCH

Ecotoxicological evaluation of low-concentration bisphenol A exposure on the soil nematodeCaenorhabditis elegansand intrinsic mechanisms of stress response in vivo

(2016) Dong Zhou et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

(2016) Sarah A. Johnson et al.   HORMONES AND BEHAVIOR

Risk factors in autism: Thinking outside the brain

(2016) Lauren Matelski et al.   JOURNAL OF AUTOIMMUNITY

Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation

(2016) Swati Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI

(2016) Ellen V.S. Hessel et al.   REPRODUCTIVE TOXICOLOGY

Impairment of object recognition memory by maternal bisphenol A exposure is associated with inhibition of Akt and ERK/CREB/BDNF pathway in the male offspring hippocampus

(2016) Chong Wang et al.   TOXICOLOGY

Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders

(2016) Carl Ernst   TRENDS IN NEUROSCIENCES

Low-dose effect of developmental bisphenol A exposure on sperm count and behaviour in rats

(2016) U. Hass et al.   Andrology

Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats

(2016) Zhi-Hua Liu et al.   Scientific Reports

Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice

(2015) Eiki Kimura et al.   ARCHIVES OF TOXICOLOGY

Bisphenol A Exposure in Children With Autism Spectrum Disorders

(2015) T. Peter Stein et al.   Autism Research

Effect of bisphenol A on Drosophila melanogaster behavior – A new model for the studies on neurodevelopmental disorders

(2015) Kulbir Kaur et al.   BEHAVIOURAL BRAIN RESEARCH

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Bisphenol A Interaction With Brain Development and Functions

(2015) P. Negri-Cesi   Dose-Response

Global Assessment of Bisphenol A in the Environment

(2015) Jone Corrales et al.   Dose-Response

Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort

(2015) Maribel Casas et al.   ENVIRONMENTAL RESEARCH

A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound

(2015) Soria Eladak et al.   FERTILITY AND STERILITY

Low circulating levels of bisphenol-A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys

(2015) John D. Elsworth et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Axon guidance proteins in neurological disorders

(2015) Eljo Y Van Battum et al.   LANCET NEUROLOGY

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

(2015) Cassandra D. Kinch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bisphenol A and its structural analogues in household waste paper

(2015) K. Pivnenko et al.   WASTE MANAGEMENT

In Vitro Models for Neurogenesis

(2015) Hassan Azari et al.   Cold Spring Harbor Perspectives in Biology

Dendritic spine dynamics leading to spine elimination after repeated inductions of LTD

(2015) Sho Hasegawa et al.   Scientific Reports

Kuwanon V Inhibits Proliferation, Promotes Cell Survival and Increases Neurogenesis of Neural Stem Cells

(2015) Sun-Young Kong et al.   PLoS One

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

A Survey of Alkylphenols, Bisphenols, and Triclosan in Personal Care Products from China and the United States

(2014) Chunyang Liao et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Bisphenol a regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor

(2014) Xiao-Bin Xu et al.   HIPPOCAMPUS

Neuroendocrine targets of endocrine disruptors

(2014) Andrea Gore   Hormones-International Journal of Endocrinology and Metabolism

Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/β-Catenin Pathway

(2014) Shashi Kant Tiwari et al.   MOLECULAR NEUROBIOLOGY

Synapse Assembly and Neurodevelopmental Disorders

(2014) Philip Washbourne   NEUROPSYCHOPHARMACOLOGY

Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A

(2014) Chong Wang et al.   TOXICOLOGY

Neurogenesis in the embryonic and adult brain: same regulators, different roles

(2014) Noelia Urbán et al.   Frontiers in Cellular Neuroscience

Dynamic learning and memory, synaptic plasticity and neurogenesis: an update

(2014) Ales Stuchlik   Frontiers in Behavioral Neuroscience

Bisphenol A increases aP2 expression in 3T3L1 by enhancing the transcriptional activity of nuclear receptors at the promoter

(2014) Ella Atlas et al.   Adipocyte

Bisphenol A affects axonal growth, musculature and motor behavior in developing zebrafish

(2013) Xuechun Wang et al.   AQUATIC TOXICOLOGY

Aminopropyl carbazole analogues as potent enhancers of neurogenesis

(2013) Hye Jin Yoon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice

(2013) Xiaohong Xu et al.   CHEMOSPHERE

Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway

(2013) Xiaohong Xu et al.   CHEMOSPHERE

Non-Monotonic Dose Responses in Studies of Endocrine Disrupting Chemicals: Bisphenol a as a Case Study

(2013) Laura N. Vandenberg   Dose-Response

Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course

(2013) Olivia S. Anderson et al.   FASEB JOURNAL

Evidence for dysregulation of axonal growth and guidance in the etiology of ASD

(2013) Kathryn McFadden et al.   Frontiers in Human Neuroscience

Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice

(2013) Shingo Matsuda et al.   HORMONES AND BEHAVIOR

Concentrations and Profiles of Bisphenol A and Other Bisphenol Analogues in Foodstuffs from the United States and Their Implications for Human Exposure

(2013) Chunyang Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates

(2013) John D. Elsworth et al.   NEUROTOXICOLOGY

Evaluation of a Screening System for Obesogenic Compounds: Screening of Endocrine Disrupting Compounds and Evaluation of the PPAR Dependency of the Effect

(2013) Anna Pereira-Fernandes et al.   PLoS One

Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review

(2012) Marijke de Cock et al.   ACTA PAEDIATRICA

Estrogen-Induced Memory Enhancements Are Blocked by Acute Bisphenol A in Adult Female Rats: Role of Dendritic Spines

(2012) T. Inagaki et al.   ENDOCRINOLOGY

Sex and dose-dependent effects of developmental exposure to bisphenol A on anxiety and spatial learning in deer mice (Peromyscus maniculatus bairdii) offspring

(2012) Eldin Jašarević et al.   HORMONES AND BEHAVIOR

The environmental obesogen bisphenol A promotes adipogenesis by increasing the amount of 11β-hydroxysteroid dehydrogenase type 1 in the adipose tissue of children

(2012) J Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Fetal Liver Bisphenol A Concentrations and Biotransformation Gene Expression Reveal Variable Exposure and Altered Capacity for Metabolism in Humans

(2012) Muna S. Nahar et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Comparing United States and Canadian population exposures from National Biomonitoring Surveys: Bisphenol A intake as a case study

(2012) Judy S LaKind et al.   Journal of Exposure Science and Environmental Epidemiology

Wnt Signaling in Vertebrate Neural Development and Function

(2012) Kimberly A. Mulligan et al.   Journal of Neuroimmune Pharmacology

Stem Cells in Drug Screening for Neurodegenerative Disease

(2012) Hyun-Jung Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Social influences on neuroplasticity: stress and interventions to promote well-being

(2012) Richard J Davidson et al.   NATURE NEUROSCIENCE

High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations

(2012) Young Jung Jang et al.   TOXICOLOGY

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats.

(2011) Tehila Eilam-Stock et al.   BEHAVIORAL NEUROSCIENCE

Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior

(2011) Keiko Nakamura et al.   BRAIN & DEVELOPMENT

Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A

(2011) Rong Zhou et al.   NEUROPHARMACOLOGY

Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish

(2011) Katerine S. Saili et al.   TOXICOLOGY

Transfer of bisphenol A across the human placenta

(2010) Biju Balakrishnan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Epigenetic control of stem cell fate to neurons and glia

(2010) Hyun-Jung Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders

(2010) Martha R Herbert   CURRENT OPINION IN NEUROLOGY

Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus

(2010) Miyu Nishikawa et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-d-aspartate receptors of hippocampus in male offspring mice

(2010) Xiao-hong Xu et al.   HORMONES AND BEHAVIOR

Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice

(2010) Kimberly H. Cox et al.   HORMONES AND BEHAVIOR

Bisphenol-A can bind to human glucocorticoid receptor as an agonist: an in silico study

(2010) G. K. Prasanth et al.   JOURNAL OF APPLIED TOXICOLOGY

Epigenetic control of neural precursor cell fate during development

(2010) Yusuke Hirabayashi et al.   NATURE REVIEWS NEUROSCIENCE

Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A

(2010) A. Poimenova et al.   NEUROSCIENCE

Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice

(2010) Yu-Hua Tian et al.   SYNAPSE

Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats

(2010) Donald G. Stump et al.   TOXICOLOGICAL SCIENCES

Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders

(2010) Stevens   Frontiers in Neuroscience

The Politics of Plastics: The Making and Unmaking of Bisphenol A “Safety”

(2009) Sarah A. Vogel   AMERICAN JOURNAL OF PUBLIC HEALTH

Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium

(2009) Tinne Geens et al.   CHEMOSPHERE

Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption

(2009) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat

(2009) Emmanuel Somm et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay

(2009) Hong Sun et al.   TOXICOLOGY IN VITRO

Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A

(2008) R. Zhou et al.   NEUROSCIENCE

Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates

(2008) C. Leranth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats

(2007) Csaba Leranth et al.   ENDOCRINOLOGY