Article
Environmental Sciences
Rong Zhou, Ru Liu, Weixin Li, Yixuan Wang, Xiang Wan, Ninghui Song, Yue Yu, Jiaming Xu, Yuanqing Bu, Aiguo Zhang
Summary: The study revealed that the toxic effects of atrazine on Caenorhabditis elegans were concentration-dependent, leading to changes in body length, lifespan, intestinal ROS levels, locomotion behavior, and brood size. Additionally, atrazine may influence the biological activities of nematodes by modulating the mtUPR pathway.
Article
Environmental Sciences
Rong Zhou, Yue Yu, Huan Miao, Na Zhao, Yuanqing Bu, Houhu Zhang
Summary: In this study, the toxicity of the herbicide atrazine and its main metabolites, deethylatrazine (DEA) and deisopropylatrazine (DIA), was compared using the in vivo model Caenorhabditis elegans. The results showed that DEA and DIA had lower toxicity on locomotion and reproduction compared to atrazine. Additionally, DEA and DIA induced less transgenerational toxicity on locomotion than atrazine and caused less oxidative stress and alteration in gene expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yunjiang Yu, Haibo Chen, Xin Hua, Zhengdong Wang, Liangzhong Li, Zongrui Li, Mingdeng Xiang, Ping Ding
Summary: Exposure to lindane induced adverse physiological effects, oxidative stress, and cell apoptosis in Caenorhabditis elegans. The toxicity of lindane in nematodes may be associated with oxidative stress and cell apoptosis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemical Research Methods
Sarah Clark, Hanbin Jeong, April Goehring, Yunsik Kang, Eric Gouaux
Summary: This study presents a detailed protocol for isolating membrane protein complexes from transgenic Caenorhabditis elegans. The genetically modified worms are grown abundantly using standard laboratory equipment, and purification conditions are optimized on a small scale using fluorescence-detection size-exclusion chromatography. The optimized conditions are then applied to a large-scale preparation, allowing for the purification of sufficient quantities of target proteins for structural, biochemical, and biophysical studies. The utility of this approach is demonstrated by successfully isolating membrane protein complexes from transgenic C. elegans.
Article
Chemistry, Inorganic & Nuclear
Hui Chong, Chuan Tan, Siyu Fang, Xichen Chen, Qi Tao, Xiaohui Yuan, Jinzhi Li, Cunhui Zhai, Chengxin Fei, Di Yang, Hongying Fan, Hongxia Shao, Aijian Qin, Guoxiu Wang, Zhonghua Shi, Ting Z'hang, Hang Yao, Hualing Li, Chengyin Wang
Summary: Two novel BODIPY-bearing complexes with pyridine and pyrimidine motifs showed stronger interactions with DNA compared to cisplatin. They exhibited improved anti-chemoresistance capabilities and significantly decreased lifespan and body length in a cisplatin-resistant model. Upregulation of certain genes related to chemoresistance was observed upon exposure to cisplatin, but not to the synthesized Pt(II) complexes.
INORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhang
Summary: Exposure to tri-n-butyl phosphate (TnBP) may reduce reproductive ability, increase germ cell apoptosis and DNA damage, and elevate oxidative stress levels in Caenorhabditis elegans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Kan Fu, Jianchun Zhang, Lanying Wang, Xu Zhao, Yanping Luo
Summary: Xanthotoxin (XAT) has various adverse effects on Caenorhabditis elegans, including reducing hatchability, increasing body length and width, decreasing reproductive capacity, and inducing apoptosis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yu Liu, Weiping Zhang, Ying Wang, Huimin Liu, Shouan Zhang, Xiaoxue Ji, Kang Qiao
Summary: Fluopyram is a widely used succinate dehydrogenase inhibitor fungicide and nematicide in agricultural pest control, which has toxic effects on non-target organisms. This study evaluated the toxic effect of fluopyram using the model organism Caenorhabditis elegans, showing that sublethal exposure to fluopyram caused damage to various physiological, biochemical, and molecular indicators in the nematodes, including oxidative stress, intestinal damage, and cell apoptosis. Pearson correlation analyses revealed significant correlations between various parameters, indicating that fluopyram induced multiple toxic effects in C. elegans, with oxidative stress, intestinal damage, and cell apoptosis playing major roles in its toxicity.
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Environmental Sciences
Shiling Liu, Qiqi Wu, Yanru Zhong, Zongzhe He, Zhen Wang, Rui Li, Minghua Wang
Summary: Fosthiazate, a potent nematicide, has been used extensively for controlling root-knot nematodes and other herbivorous nematodes. However, its toxicity to non-target nematodes is still unclear. In this study, we investigated the toxicity and mechanisms of fosthiazate in Caenorhabditis elegans, a non-target nematode species. Our results showed that fosthiazate exposure above 0.01 mg/L caused growth inhibition, locomotion impairment, and reproductive damage in the nematodes. Reactive oxygen species production and lipofuscin accumulation were increased in nematodes exposed to 1 mg/L fosthiazate. The activity of acetylcholinesterase was significantly inhibited by 0.1 mg/L fosthiazate treatment. Furthermore, exposure to 10 mg/L fosthiazate altered the expression of genes involved in oxidative stress, reproduction, and nerve function. The cyp-35a family gene was found to be responsible for the metabolism of fosthiazate in C. elegans, with the cyp-35a5 subtype being the most sensitive. These findings suggest that oxidative stress, reproductive and neurological disorders play crucial roles in the toxicity of fosthiazate in C. elegans and may have implications for soil nematodes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Yahyah Amen, Annmary Paul, Nikolao Tataridas-Pallas, Rhianna Williams, Rachel Wellman, Hannah Chapman, John Labbadia
Summary: The research shows that reducing the activity of a mitochondrial protein can suppress age-related proteostasis collapse in Caenorhabditis elegans, indicating a potential way to maintain protein integrity in aging cells.
Article
Multidisciplinary Sciences
Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida
Summary: The study highlights the importance of communication between neuronal DAF-16 and intestinal DAF-16 in regulating organismal lifespan.
Article
Environmental Sciences
Shuting Wang, Huanliang Liu, Man Qu, Dayong Wang
Summary: Neurotransmission related signals, specifically tyramine and glutamate, play crucial roles in regulating the toxicity of nanoplastics in Caenorhabditis elegans. Tyramine induces toxicity while glutamate alleviates toxicity, with both signals being mediated through neurons. Tyramine receptor TYRA-2 and glutamate receptors GLR-4 and GLR-8 act upstream of specific signaling pathways to regulate nanoplastic toxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Haibo Chen, Xin Hua, Hui Li, Chen Wang, Yao Dang, Ping Ding, Yunjiang Yu
Summary: This study found that maternal exposure to PS-MPs can result in the transgenerational neurotoxicity in C. elegans, with oxidative stress playing a key role in this process. Furthermore, the upregulation of oxidative stress-related genes across generations may be involved in regulating neurotoxicity in C. elegans.
Article
Biochemistry & Molecular Biology
Sai-Ya Zhang, Zi-Chen Qin, Yi-Yang Sun, Yu-Si Chen, Wen-Bo Chen, Hong-Gang Wang, Di An, Dan Sun, Yan-Qiang Liu
Summary: The study investigates the anti-heat stress and antioxidant effects of genistein in C. elegans. It is found that genistein significantly extends the lifespan of C. elegans, reduces the accumulation of lipofuscin and reactive oxygen species, and regulates the expression of aging-related genes. These effects are mediated through insulin-like growth factor signaling, heat shock protein, mitogen-activated protein kinase, dietary restriction, and mitochondrial pathways.
Article
Environmental Sciences
Fuwen Liu, Qishi Luo, Ying Zhang, Kai Huang, Xue Cao, Changzheng Cui, Kuangfei Lin, Meng Zhang
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Fuwen Liu, Ying Zhang, Meng Zhang, Qishi Luo, Xue Cao, Changzheng Cui, Kuangfei Lin, Kai Huang
Article
Engineering, Environmental
Gehui Wang, Xiaoqian Xia, Jie Yang, Muhammad Tariq, Jun Zhao, Meng Zhang, Kai Huang, Kuangfei Lin, Wei Zhang
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Environmental Sciences
Kai Huang, Hao Bian, Meng Zhang, Cong Zhan, Can Li, Wei Zhang, Changzheng Cui, Qiang Lu, Kuangfei Lin, Jianhua Zhao
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Ecology
Xin Chen, Weiwei Wang, Haiyang Hu, Hongzhi Tang, Yongdi Liu, Ping Xu, Kuangfei Lin, Changzheng Cui
Summary: This study identified differentially expressed proteins in high salt environments, showing that Martelella AD-3 strain relies on RHD and dihydrodiol dehydrogenase for phenanthrene degradation and accumulates compatible solutes for salt stress resistance.
Article
Engineering, Environmental
Guanhong Liu, Meiyun Feng, Muhammad Tayyab, Jianqiu Gong, Meng Zhang, Mingyang Yang, Kuangfei Lin
Summary: A bimetallic AlCNi structure was synthesized successfully in this study, showing high efficiency in removing PFOA pollutants. Multiple characterizations confirmed the predominant degradation pathways, providing feasibility for PFOA treatment without the need for chemical agents.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Physical
Haotian Mei, Qi Wang, Guanhong Liu, Xudong Zhu, Meng Zhang, Kai Huang, Kuangfei Lin
Summary: The study demonstrated that nZVI@CN synthesized via liquid phase reduction method as a PMS activator showed efficient degradation of PX, especially when prepared with a 1:1 mass ratio. The catalyst exhibited high stability and reusability, with removal efficiency of PX reaching over 90% under optimal conditions.
Article
Engineering, Environmental
Qi Wang, Dongmei Zhou, Kuangfei Lin, Xiurong Chen
Summary: Nonradical-based advanced oxidation processes show great promise in pollutant removal due to their superior characteristics. In this study, carbon nitride-based cuprous catalysts were found to effectively activate peroxydisulfate for the degradation of Tetrabromobisphenol A. The primary ROS in the system was unveiled to be singlet oxygen generated from superoxide anions and dissolved oxygen. This study provides insights into the mechanism of PDS activation by carbon nitride-based cuprous catalysts and offers an innovative catalytic system for in situ chemical oxidation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Environmental Sciences
Shijie Yao, Jianfeng Ye, Qing Yang, Yaru Hu, Tianyang Zhang, Lei Jiang, Salvator Munezero, Kuangfei Lin, Changzheng Cui
Summary: Hospital wastewater contains a variety of human antibiotics and pathogens, with a lack of research on pollutants at treatment plants. Different hospitals showed varying levels of antibiotics and ARGs in their wastewater. The study revealed the co-occurrence of antibiotics, ARGs, and antibiotic-resistant pathogens in hospital wastewater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Qi Wang, Cun Liu, Dongmei Zhou, Xiurong Chen, Meng Zhang, Kuangfei Lin
Summary: Peroxymonosulfate-assisted advanced oxidation processes (PMS-AOPs) catalyzed by single-atom catalysts have been developed for the degradation of bisphenol A (BPA) using cobalt single-atom catalysts supported by graphitic carbon nitride (SA-CoCN). The study revealed that high-valent cobalt [Co(IV)] and singlet oxygen (O-1(2)) were the main reactive species for pollutant degradation under acidic and alkaline conditions, rather than the commonly accepted free radicals (SO4 center dot- and center dot OH).
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Meiyun Feng, Zhiqiang Xu, Xue Bai, Kuangfei Lin, Meng Zhang
Summary: This study compared the morphology and surface characteristics of different MxMn3-xO4 nanoparticles and their catalytic performance for PMS activation to degrade TCE. The results showed that cubic spinel catalysts exhibited higher catalytic activity and TCE removal efficiency compared to tetragonal spinel catalysts. The nanoparticles also demonstrated reusability and a wide applicable pH range. Free radical scavenging experiments and EPR analysis confirmed the importance of free radicals generated by cubic spinels in TCE removal.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Shijie Yao, Jianfeng Ye, Jing Xia, Yaru Hu, Xuetao Zhao, Jianhao Xie, Kuangfei Lin, Changzheng Cui
Summary: This study revealed the mechanisms of inactivation and photoreactivation of the super-resistant bacterium Acinetobacter sp. CS-2 by UV, chlorination, and UV/chlorination disinfection. CS-2 showed certain photoreactivation after UV and chlorination treatment. UV/chlorination resulted in high-efficiency reduction of CS-2 and effectively controlled its photoreactivation. Compared with UV disinfection, UV/chlorination caused irreversible destruction to bacterial surface structures, leading to better disinfection efficacy. The singlet oxygen (1O2) generated during UV/chlorination treatment played a vital role in the removal of the blaNDM-1 gene.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Guanhong Liu, Jiahao Qian, Yu Zhang, Kuangfei Lin, Fuwen Liu
Summary: This study focused on the thermal treatment of PFOA contaminated soil, using fresh activated carbon (FAC) and modified activated carbon (NAC) as heterogeneous catalysts. The results showed that a significant reduction in PFOA levels was achieved with the use of FAC/PMS and NAC/PMS at 60°C.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Guanhong Liu, Chao Li, Brittney Ashley Stewart, Lin Liu, Meng Zhang, Mingyang Yang, Kuangfei Lin
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Environmental Sciences
Meng Zhang, Cong Lu, Wei Zhang, Kuangfei Lin, Kai Huang