Current and Future Biomarkers in Multiple Sclerosis

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

An emerging potential of metabolomics in multiple sclerosis: a comprehensive overview

(2021) Insha Zahoor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A candidate biomarker of glial fibrillary acidic protein in CSF and blood in differentiating multiple sclerosis and its subtypes: A systematic review and meta-analysis

(2021) MengJiao Sun et al.   Multiple Sclerosis and Related Disorders

Alterations of the gut mycobiome in patients with MS

(2021) Saumya Shah et al.   EBioMedicine

Predicting Aggressive Multiple Sclerosis With Intrathecal IgM Synthesis Among Patients With a Clinically Isolated Syndrome

(2021) Enric Monreal et al.   Neurology-Neuroimmunology & Neuroinflammation

Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis

(2021) Camilo E. Fadul et al.   Neurology-Neuroimmunology & Neuroinflammation

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

(2020) David Schafflick et al.   Nature Communications

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

(2020) Ali Manouchehrinia et al.   Annals of Clinical and Translational Neurology

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

(2020) Pavan Bhargava et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

(2020) Jesse Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune and central nervous system-related miRNAs expression profiling in monocytes of multiple sclerosis patients

(2020) Antonella Amoruso et al.   Scientific Reports

Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression

(2020) Qing Meng et al.   Frontiers in Physiology

Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation

(2020) Ekaterina Esaulova et al.   Neurology-Neuroimmunology & Neuroinflammation

Monitoring of radiologic disease activity by serum neurofilaments in MS

(2020) Tomas Uher et al.   Neurology-Neuroimmunology & Neuroinflammation

Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

(2020) Simon Thebault et al.   Scientific Reports

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

(2020) Akshaya Ramesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

(2020) Helena Beatriz Ferreira et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS

(2020) Adil Harroud et al.   Neurology-Neuroimmunology & Neuroinflammation

Bidirectional regulatory potentials of short-chain fatty acids and their G-protein-coupled receptors in autoimmune neuroinflammation

(2019) Jeongho Park et al.   Scientific Reports

Profiling individual clinical responses by high-frequency serum neurofilament assessment in MS

(2019) Katja Akgün et al.   Neurology-Neuroimmunology & Neuroinflammation

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years

(2019) Ester Cantó et al.   JAMA Neurology

Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis

(2019) Kjetil Bjornevik et al.   JAMA Neurology

Altered Levels of Toll-Like Receptors in Circulating Extracellular Vesicles in Multiple Sclerosis

(2019) Pavan Bhargava et al.   Cells

Exosomal microRNA in autoimmunity

(2019) Weijia Duan et al.   Cellular & Molecular Immunology

Molecular biomarkers in multiple sclerosis

(2019) Tjalf Ziemssen et al.   Journal of Neuroinflammation

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis

(2018) Christian Barro et al.   BRAIN

CSF free light chain identification of demyelinating disease: comparison with oligoclonal banding and other CSF indexes

(2018) Kari M. Gurtner et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

(2018) Kimitoshi Kimura et al.   Nature Communications

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

(2018) Damiana Pieragostino et al.   Scientific Reports

Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis

(2018) Elizabeth A. Mills et al.   Frontiers in Neurology

Impact of trial design and patient heterogeneity on the identification of clinically effective therapies for progressive MS

(2018) Elizabeth A Mills et al.   Multiple Sclerosis Journal

Differences in Intercellular Communication During Clinical Relapse and Gadolinium-Enhanced MRI in Patients With Relapsing Remitting Multiple Sclerosis: A Study of the Composition of Extracellular Vesicles in Cerebrospinal Fluid

(2018) Fabiana Geraci et al.   Frontiers in Cellular Neuroscience

Atrophied brain lesion volume, a magnetic resonance imaging biomarker for monitoring neurodegenerative changes in multiple sclerosis

(2018) Robert Zivadinov et al.   QUANTITATIVE IMAGING IN MEDICINE AND SURGERY

Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients

(2017) Qi Wu et al.   JOURNAL OF IMMUNOLOGY

Long-Term Magnetization Transfer Ratio Evolution in Multiple Sclerosis White Matter Lesions

(2017) Yufan Zheng et al.   JOURNAL OF NEUROIMAGING

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

(2017) Clara Matute-Blanch et al.   JOURNAL OF NEUROIMMUNOLOGY

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

(2017) Martin Hardmeier et al.   Multiple Sclerosis Journal

Multiple sclerosis: Serum-derived exosomes express myelin proteins

(2017) Grazyna Galazka et al.   Multiple Sclerosis Journal

Defining active progressive multiple sclerosis

(2017) Finn Sellebjerg et al.   Multiple Sclerosis Journal

Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis

(2017) Yang Mao-Draayer et al.   Neural Regeneration Research

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

(2017) Lenka Novakova et al.   NEUROLOGY

The influence of gut-derived CD39 regulatory T cells in CNS demyelinating disease

(2017) Javier Ochoa-Repáraz et al.   Translational Research

Multiple sclerosis: Pathology, diagnosis and treatments

(2017) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

(2017) Ashraful Haque et al.   Genome Medicine

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

(2017) Martin Hardmeier et al.   Multiple Sclerosis Journal

Multiple sclerosis: Serum-derived exosomes express myelin proteins

(2017) Grazyna Galazka et al.   Multiple Sclerosis Journal

Defining active progressive multiple sclerosis

(2017) Finn Sellebjerg et al.   Multiple Sclerosis Journal

Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse

(2017) Elizabeth A. Mills et al.   Frontiers in Neurology

Recent advances of exosomes in immune modulation and autoimmune diseases

(2016) Lina Tan et al.   AUTOIMMUNITY

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis

(2016) Cather M. Cala et al.   JOURNAL OF NEUROIMMUNOLOGY

Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis

(2016) C. Boiocchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Sulfatides in extracellular vesicles isolated from plasma of multiple sclerosis patients

(2016) Ana Lis Moyano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

(2016) Helen Tremlett et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Intrathecal lipid-specific oligoclonal IgM synthesis associates with retinal axonal loss in multiple sclerosis

(2016) José C. Álvarez-Cermeño et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing–remitting multiple sclerosis

(2016) Jonas Ahlbrecht et al.   Multiple Sclerosis Journal

Brain MRI atrophy quantification in MS

(2016) Maria A. Rocca et al.   NEUROLOGY

Multiple sclerosis prevalence in the United States commercially insured population

(2016) Piyameth Dilokthornsakul et al.   NEUROLOGY

The gut–brain connection: triggering of brain autoimmune disease by commensal gut bacteria

(2016) Hartmut Wekerle   RHEUMATOLOGY

Linking the Microbiota, Chronic Disease, and the Immune System

(2016) Timothy W. Hand et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing–remitting multiple sclerosis

(2016) Jonas Ahlbrecht et al.   Multiple Sclerosis Journal

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment

(2015) Juergen Rech et al.   ANNALS OF THE RHEUMATIC DISEASES

No prognostic value of routine cerebrospinal fluid biomarkers in a population-based cohort of 407 multiple sclerosis patients

(2015) Madlyne Becker et al.   BMC Neurology

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

(2015) G Hinsinger et al.   Multiple Sclerosis Journal

The tantalizing links between gut microbes and the brain

(2015) Peter Andrey Smith   NATURE

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

(2015) G Hinsinger et al.   Multiple Sclerosis Journal

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Extracellular cell stress proteins as biomarkers of human disease

(2014) A. Graham Pockley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Comparison of diffusion-weighted imaging and contrast-enhanced T1-weighted imaging on a single baseline MRI for demonstrating dissemination in time in multiple sclerosis

(2014) Chung-Ping Lo et al.   BMC Neurology

The Symbol Digit Modalities Test as sentinel test for cognitive impairment in multiple sclerosis

(2014) J. Van Schependom et al.   EUROPEAN JOURNAL OF NEUROLOGY

Expression, Regulation and Function of MicroRNAs in Multiple Sclerosis

(2014) Xinting Ma et al.   International Journal of Medical Sciences

Positive or Negative Involvement of Heat Shock Proteins in Multiple Sclerosis Pathogenesis

(2014) Giuseppina Turturici et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Molecular Network Analysis of T-Cell Transcriptome Suggests Aberrant Regulation of Gene Expression by NF-κB As a Biomarker for Relapse of Multiple Sclerosis

(2013) Jun-ichi Satoh et al.   DISEASE MARKERS

MicroRNA dysregulation in multiple sclerosis

(2013) Omar de Faria Jr et al.   Frontiers in Genetics

High levels of cerebrospinal fluid free kappa chains predict conversion to multiple sclerosis

(2012) Luisa M. Villar et al.   CLINICA CHIMICA ACTA

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis

(2012) Y. Liu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Serum level of interleukin-6 in Chinese patients with multiple sclerosis

(2012) Ying-Chun Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Disease Biomarkers in Multiple Sclerosis

(2012) Violaine K. Harris et al.   Molecular Diagnosis & Therapy

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(2012) Maria Mansilla et al.   MOLECULAR MEDICINE

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

(2012) Jeppe Romme Christensen et al.   Multiple Sclerosis Journal

Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis

(2012) Roberto Madeddu et al.   NEUROLOGICAL SCIENCES

Repeatability and variation of region-of-interest methods using quantitative diffusion tensor MR imaging of the brain

(2012) Ullamari Hakulinen et al.   BMC MEDICAL IMAGING

Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis

(2011) E Cantó et al.   Multiple Sclerosis Journal

Progressive decline in fractional anisotropy on serial DTI examinations of the corpus callosum: a putative marker of disease activity and progression in SPMS

(2011) Wei Tian et al.   NEURORADIOLOGY

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

(2011) Kristin M. Galetta et al.   Neurotherapeutics

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Acute exacerbation of multiple sclerosis increases plasma levels of S-100 protein

(2010) U. Missler et al.   ACTA NEUROLOGICA SCANDINAVICA

Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis

(2010) Manuel Comabella et al.   BRAIN

The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis

(2010) Kaushal S. Gandhi et al.   HUMAN MOLECULAR GENETICS

Glial Amyloid Precursor Protein Expression is Restricted to Astrocytes in an Experimental Toxic Model of Multiple Sclerosis

(2010) Tim Clarner et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis

(2010) Chris H Polman et al.   LANCET NEUROLOGY

Neurofilament light as a prognostic marker in multiple sclerosis

(2010) Jonatan Salzer et al.   Multiple Sclerosis Journal

Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis

(2010) Emma C Tallantyre et al.   Multiple Sclerosis Journal

Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course

(2010) Mohsen Khademi et al.   Multiple Sclerosis Journal

NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis

(2009) J. Yan et al.   CNS & Neurological Disorders-Drug Targets

Aquaporin-4 Antibodies in Neuromyelitis Optica and Longitudinally Extensive Transverse Myelitis

(2008) Patrick Waters et al.   ARCHIVES OF NEUROLOGY

Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis

(2008) S. Presslauer et al.   JOURNAL OF NEUROLOGY

Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis

(2008) M Thangarajh et al.   Multiple Sclerosis Journal

Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex

(2008) M Matysiak et al.   Multiple Sclerosis Journal

Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis

(2008) Katharina Hein (née Maier) et al.   NEUROSCIENCE LETTERS

Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy

(2007) Martin Eggert et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES