Article
Oncology
Xiao Wu, Liping Jiang, Zeng Zhang, Yanming He, Yilong Teng, Jiaqi Li, Shilin Yuan, Yanna Pan, Haohui Liang, Hongjie Yang, Ping Zhou
Summary: Fudan-Yueyang-Ganoderma lucidum (FYGL) selectively inhibits the viability of PANC-1 and BxPC-3 pancreatic cancer cells by suppressing Bcl-2 expression, increasing ROS levels, and inhibiting autophagy, ultimately promoting apoptosis through the caspase-3/cleaved caspase-3 cascade.
Article
Plant Sciences
Yanna Pan, Ying Zhang, Jiaqi Li, Zeng Zhang, Yanming He, Qingjie Zhao, Hongjie Yang, Ping Zhou
Summary: This study aims to investigate and evaluate the efficacy of a protective pluripotency factor secreted by stem cells in improving the treatment of diabetic kidney disease. The results suggest that this factor can reduce renal dysfunction caused by oxidative stress and improve kidney function in diabetic patients.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Mario A. Miranda, Juan F. Macias-Velasco, Heather A. Lawson
Summary: The review examines the heterogeneity of pancreatic beta-cells from morphological, functional, and transcriptional perspectives, considering factors such as topography, maturation, development, and stress response. It discusses the identification of beta-cell subtypes and how heterogeneity is influenced by diabetes. The paper also explores open questions in the field and recent technological innovations that could advance understanding of beta-cell heterogeneity in health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Zijing Chen, Leah Truskinovsky, Emmanuel S. Tzanakakis
Summary: This review discusses the application of optical methods, including optogenetics, optochemical, and photopharmacological strategies, in pancreatic cells and tissues. It highlights the potential of these methods in regulating insulin secretion and controlling blood sugar levels. Optical methods offer greater precision and controllability compared to traditional drugs, providing new possibilities for addressing pancreatic pathologies.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Akinobu Nakamura
Summary: SGLT2 inhibitors not only lower blood glucose levels but also have protective effects on organs such as the heart and kidneys. These inhibitors prevent beta-cell dysfunction by reducing glucose overload, leading to increased beta-cell proliferation and decreased apoptosis. Clinical and preclinical data support the protective effect of SGLT2 inhibitors on beta-cell mass and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Noura Aldous, Abu Saleh Md Moin, Essam M. Abdelalim
Summary: Recent studies have shown that pancreatic beta-cells are heterogeneous in their transcriptional profiles and insulin secretion abilities. Different sub-populations of beta-cells have been identified based on functionality and surface markers. Understanding the heterogeneity of beta-cells and their interactions with other endocrine cells is crucial for developing stem cell-derived therapies for diabetes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shun-ichiro Asahara, Hiroyuki Inoue, Hitoshi Watanabe, Yoshiaki Kido
Summary: Pancreatic beta-cells are the only cells that can control glycemic levels through insulin secretion. Studies have found that mTOR plays a significant role in the function of beta-cells and the progression of diabetes.
Article
Biochemistry & Molecular Biology
Reinaldo Sousa Dos Santos, Regla Maria Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Summary: Identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity are necessary. This study used various cell lines to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). Results suggest that one chemical could be a new diabetogenic agent, and the EndoC-beta H1 cell line is a suitable human beta-cell model for testing diabetogenic MDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Eva Tuduri, Sergi Soriano, Lucia Almagro, Eduard Montanya, Paloma Alonso-Magdalena, Angel Nadal, Ivan Quesada
Summary: This review summarizes the age-related alterations, adaptations, and failures of pancreatic β-cells at the molecular, morphological, and functional levels in both mice and humans. The findings suggest that changes in β-cell proliferation, apoptosis, and function with age may impact the development of type 2 diabetes.
AGEING RESEARCH REVIEWS
(2022)
Review
Food Science & Technology
Camelia Papuc, Gheorghe V. Goran, Corina N. Predescu, Liliana Tudoreanu, Georgeta Stefan
Summary: Diabetes is a metabolic disorder characterized by high blood sugar levels with detrimental effects on various systems. Plant polyphenols have shown beneficial activity for diabetes prevention and treatment. This review article summarizes the mechanisms by which polyphenols decrease insulin resistance and inhibit loss of pancreatic islet beta-cell mass and function, as well as their effects on insulin release.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Toxicology
Jenna E. Todero, Kieran Koch-Laskowski, Qing Shi, Matt Kanke, Yu-Han Hung, Rowan Beck, Miroslav Styblo, Praveen Sethupathy
Summary: Arsenic, a pervasive environmental toxin, can cause type 2 diabetes through chronic exposure. This study reveals that arsenic treatment impairs insulin secretion in pancreatic beta cells and alters the microRNA profile. Multi-omic analysis shows that arsenic affects pathways related to insulin secretion and diabetes, and different forms of arsenic have distinct effects on cell cycle and beta cell maintenance factors. miR-29a is identified as a potential master regulator of these genes.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomonori Tsuyama, Yoshifumi Sato, Tatsuya Yoshizawa, Takaaki Matsuoka, Kazuya Yamagata
Summary: Hypoxia-induced transcriptional repressor BHLHE40 suppresses insulin secretion by inhibiting the expression of MAFA in beta-cells.
Article
Chemistry, Multidisciplinary
Fanzhen Yu, Yilong Teng, Jiaqi Li, Shutong Yang, Zeng Zhang, Yanming He, Hongjie Yang, Chuan-Fan Ding, Ping Zhou
Summary: This study investigated the effects of FYGL on pancreatic functions and gene pathways in a T2D rat model. The results showed that FYGL positively regulated T2D-related pathways, improving hyperglycemia and hyperlipidemia. The recovery of pancreatic function suggested a crucial strategy for treating T2D.
Article
Chemistry, Physical
Tran Do Dat, Nguyen Duc Viet, Nguyen Minh Dat, Phan Le Thao My, Doan Ba Thinh, Lu Thi Mong Thy, Le Minh Huong, Pham Tan Khang, Nguyen Duy Hai, Hoang Minh Nam, Mai Thanh Phong, Nguyen Huu Hieu
Summary: This study successfully synthesized silver nanoparticles using Vietnamese Ganoderma lucidum extract, showing good crystallinity and nanoparticle stability. The synthesized silver nanoparticles exhibited excellent antimicrobial and antioxidant activities against various bacteria and fungi, and showed potential in anticancer applications as well.
SURFACES AND INTERFACES
(2021)
Article
Cell Biology
Erwin Ilegems, Galyna Bryzgalova, Jorge Correia, Burcak Yesildag, Edurne Berra, Jorge L. Ruas, Teresa S. Pereira, Per-Olof Berggren
Summary: This study found the presence of HIF-1 alpha in pancreatic cells during the progression of type 2 diabetes, and demonstrated that treatment with the HIF-1 alpha inhibitor PX-478 can improve beta cell function, prevent diabetes progression, and increase insulin secretion. The results showed that PX-478 treatment has an improving effect on mouse and human islets.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)