Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation

The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

(2021) Bing Wu et al.   IMMUNITY

Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

(2021) Xinying Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

T cells selectively filter oscillatory signals on the minutes timescale

(2021) Geoff P. O’Donoghue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

(2020) Jeong-Ryul Hwang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Regulating T cell differentiation through the polyamine spermidine

(2020) Guilhermina M. Carriche et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of T Helper Cell Fate by TCR Signal Strength

(2020) Nayan D. Bhattacharyya et al.   Frontiers in Immunology

Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo

(2020) Maximilian Fischer et al.   Aging-US

Polyamines and Kynurenines at the Intersection of Immune Modulation

(2020) Elisa Proietti et al.   TRENDS IN IMMUNOLOGY

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

(2020) Ruohan Wu et al.   Science Advances

Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases

(2019) Na Suo et al.   GLIA

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

The pathogenicity of Th17 cells in autoimmune diseases

(2019) Keiko Yasuda et al.   Seminars in Immunopathology

Polyamines in mammalian pathophysiology

(2019) Francisca Sánchez-Jiménez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immunological Aspects of Approved MS Therapeutics

(2019) Paulus S. Rommer et al.   Frontiers in Immunology

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

(2018) Alan J Thompson et al.   LANCET NEUROLOGY

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

(2018) Shun Zhou et al.   Frontiers in Immunology

ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway

(2018) Xiaoling Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research

(2018) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders

(2018) Ali N. Kamali et al.   MOLECULAR IMMUNOLOGY

The functional role of polyamines in eukaryotic cells

(2018) Kazuei Igarashi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Modulation of learning and memory by natural polyamines

(2016) Gustavo Petri Guerra et al.   PHARMACOLOGICAL RESEARCH

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

(2016) Karmel A Allison et al.   eLife

Spermine reverses lipopolysaccharide-induced memory deficit in mice

(2015) Pâmella Frühauf et al.   Journal of Neuroinflammation

The function of spermine

(2014) Anthony E. Pegg   IUBMB LIFE

Identification of a mammalian vesicular polyamine transporter

(2014) Miki Hiasa et al.   Scientific Reports

Spermidine-triggered autophagy ameliorates memory during aging

(2013) Stephan J Sigrist et al.   Autophagy

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural polyamine inhibits mouse skin inflammation and macrophage activation

(2013) Souren Paul et al.   INFLAMMATION RESEARCH

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

(2012) Ruben L Smeets et al.   BMC IMMUNOLOGY

Polar Opposites: Erk Direction of CD4 T Cell Subsets

(2012) C.-F. Chang et al.   JOURNAL OF IMMUNOLOGY

Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding

(2011) Ramesh M. Ray et al.   CELLULAR SIGNALLING

Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease

(2011) Wei Cao et al.   IMMUNITY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pharmacologic Inhibition of MEK–ERK Signaling Enhances Th17 Differentiation

(2010) Andy Hee-Meng Tan et al.   JOURNAL OF IMMUNOLOGY

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

(2010) L. Lu et al.   JOURNAL OF IMMUNOLOGY

ERK inhibitors as a potential new therapy for rheumatoid arthritis

(2009) M. Ohori   DRUG NEWS & PERSPECTIVES

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

(2009) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

Age-related changes in polyamines in memory-associated brain structures in rats

(2008) P. Liu et al.   NEUROSCIENCE