Review
Behavioral Sciences
Susana Gomes-da-Costa, Wolfgang Marx, Filippo Corponi, Gerard Anmella, Andrea Murru, Maria Teresa Pons-Cabrera, Anna Gimenez-Palomo, Felipe Gutierrez-Arango, Cristian Daniel Llach, Giovanna Fico, Georgios D. Kotzalidis, Norma Verdolini, Marc Valenti, Michael Berk, Eduard Vieta, Isabella Pacchiarotti
Summary: This study found through a systematic review and meta-analysis that the use of lithium in patients with Bipolar Disorder does not significantly lead to weight gain. Shorter treatment duration is associated with more pronounced weight gain. There were no significant differences in weight gain between lithium and placebo, but weight gain with lithium was lower compared to other active comparators.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Luigi F. Saccaro, Jasper Crokaert, Nader Perroud, Camille Piguet
Summary: This systematic review analyzed the presentation of immune-related histological and functional magnetic resonance imaging (MRI) in patients with bipolar disorder (BD). The results showed that BD patients had abnormal MRI findings associated with inflammatory diseases and chronic inflammation. However, the generalizability of the study conclusions is limited due to heterogeneity in methods and results, as well as limitations in sample sizes. The qualitative synthesis revealed that the links between immune traits and functional or structural MRI alterations in BD point towards brain areas involved in affective and somatomotor processing, with a trend towards a negative correlation between peripheral inflammatory markers and brain region volume. Disentangling the complex relationship between the immune system and MRI alterations in BD may uncover mechanisms underlying symptom pathophysiology, potentially leading to quickly translatable diagnostic, prognostic, and therapeutic implications.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Zainab Nabi, Jacki Stansfeld, Martin Ploderl, Lisa Wood, Joanna Moncrieff
Summary: This study is a systematic review and meta-analysis that includes all eligible data and evaluates the effect of lithium on suicide, non-fatal suicidal behavior, and suicide attempts. The results suggest that evidence from randomized trials is inconclusive and does not support the idea that lithium prevents suicide or suicidal behavior.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Clinical Neurology
Jason Ng, Joshua D. Rosenblat, Leanna M. W. Lui, Kayla M. Teopiz, Yena Lee, Orly Lipsitz, Rodrigo B. Mansur, Nelson B. Rodrigues, Flora Nasri, Hartej Gill, Danielle S. Cha, Mehala Subramaniapillai, Roger C. Ho, Bing Cao, Roger S. McIntyre
Summary: The review and synthesis of existing literature on functional outcomes with ketamine/esketamine treatment in adults with treatment-resistant depression suggest mixed results across different functional measures, with improvements in general psychosocial functioning apparent. Future research is needed to explore the association between symptomatic improvement and functional improvement in TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Sara Poletti, Benedetta Vai, Mario Gennaro Mazza, Raffaella Zanardi, Cristina Lorenzi, Federico Calesella, Silvia Cazzetta, Igor Branchi, Cristina Colombo, Roberto Furlan, Francesco Benedetti
Summary: This study successfully predicted the differential diagnosis of MDD and BD by considering plasma levels of cytokines, chemokines, and growth factors, and found that the immune-inflammatory signature is key in distinguishing between the two disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Review
Chemistry, Medicinal
Marek Krzystanek, Stanislaw Surma, Artur Palasz, Monika Romanczyk, Krzysztof Krysta
Summary: The antidepressant effects of memantine in bipolar depression are promising, with both experimental and clinical evidence supporting its efficacy. The presented case study demonstrates that memantine can be an effective and safe adjunct treatment for mood stabilization in bipolar depression. This suggests that memantine may offer a new approach for patients who do not respond well to traditional medications.
Review
Psychiatry
Joseph Biederman, Allison Green, Maura DiSalvo, Stephen V. Faraone
Summary: The study examined the association between polygenic risk scores for bipolar disorder and pediatric mood disorders, finding that these scores were linked to deficits in executive functioning and the diagnosis of attention deficit/hyperactivity disorder (ADHD).
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Katie Benitah, Ashley N. Siegel, Orly Lipsitz, Nelson B. Rodrigues, Shakila Meshkat, Yena Lee, Rodrigo B. Mansur, Flora Nasri, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: A systematic review of published clinical studies found no significant differences in the antidepressant response, tolerability, or safety of ketamine between males and females in the treatment of mood disorders.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Konstantinos N. Fountoulakis, Mauricio Tohen, Carlos A. Zarate Jr
Summary: The study systematically reviewed the efficacy of lithium in different phases of Bipolar disorder, finding that it is effective in acute mania and maintenance treatment, either as monotherapy or in combination with other agents. However, its efficacy for acute bipolar depression requires combination with specific agents, and its efficacy in preventing depressive episodes remains unclear.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Psychiatry
Shakila Meshkat, Joshua D. Rosenblat, Roger C. Ho, Taeho Greg Rhee, Bing Cao, Felicia Ceban, Kevork Danayan, Noah Chisamore, Joshua D. Di Vincenzo, Roger S. McIntyre
Summary: Ketamine may be effective in treating pediatric depression, but there are limitations in the current research, and larger-scale studies with different administration modalities are needed.
PSYCHIATRY RESEARCH
(2022)
Review
Neurosciences
Janusz K. Rybakowski, Ewa Ferensztajn-Rochowiak
Summary: This mini-review highlights the contradiction between the positive therapeutic data of lithium and its decreased global usage. Lithium has been proven to be the best mood stabilizer in maintaining bipolar disorder, preventing manic and depressive recurrences. It is also promising in augmenting the treatment of resistant depression and has additional benefits such as antisuicidal, antiviral, immunomodulatory, and neuroprotective effects. However, the decline in lithium usage in many countries can be attributed to the promotion of other mood stabilizers and concerns over its side effects. Efforts have been made to challenge the negative perception of lithium and optimize its long-term administration.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Kaat Hebbrecht, Manuel Morrens, Erik J. Giltay, Alexander L. N. van Nuijs, Bernard Sabbe, Seline van den Ameele
Summary: In patients with bipolar disorder, lower levels of the KYN metabolite KYNA were associated with worse cognitive functioning, particularly in processing speed, only in the bipolar depression group. The manic group exhibited deficits in all cognitive domains, while throughout the follow-up period, both patient groups had significantly lower KYNA levels compared to controls. Further large-scale longitudinal studies are needed to confirm the role of KYN metabolites in cognitive impairment in BD patients and potential therapeutic implications.
NEUROPSYCHOBIOLOGY
(2022)
Article
Neurosciences
Claudia Cornelis, Livia J. De Picker, Violette Coppens, Anne Morsel, Maarten Timmers, Glenn Dumont, Bernard G. C. Sabbe, Manuel Morrens, Wouter Hulstijn
Summary: The cognitive dysmetria hypothesis suggests disrupted communication between the cerebellum and cerebral cortex in schizophrenia, leading to sensorimotor and cognitive symptoms. This study found that sensorimotor adaptation is reduced in schizophrenia patients compared to age-matched and elderly controls. Patients with schizophrenia showed impairments in both explicit and implicit components of sensorimotor adaptation learning.
NEUROPSYCHOBIOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Violette Coppens, Robert Verkerk, Manuel Morrens
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
M. Morrens, C. Overloop, V Coppens, E. Loots, M. Van den Noortgate, S. Vandenameele, M. Leboyer, L. De Picker
Summary: This meta-analysis found only weak associations between blood-based immune markers and cognition in mood and psychotic disorders. Significant publication and reporting biases were observed.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Medicine, General & Internal
M. Morrens, V. Coppens
Article
Endocrinology & Metabolism
Caroline de Gouveia Buff Passone, Gaelle Vermillac, Willem Staels, Alix Besancon, Dulanjalee Kariyawasam, Cecile Godot, Cecile Lambe, Cecile Talbotec, Muriel Girard, Christophe Chardot, Laureline Berteloot, Taymme Hachem, Alexandre Lapillonne, Amelie Poidvin, Caroline Storey, Mathieu Neve, Cosmina Stan, Emmanuelle Dugelay, Anne-Laure Fauret-Amsellem, Yline Capri, Helene Cave, Marina Ybarra, Vikash Chandra, Raphael Scharfmann, Elise Bismuth, Michel Polak, Jean Claude Carel, Benedicte Pigneur, Jacques Beltrand
Summary: This study presents the clinical management and analysis of four new cases of Mitchell-Riley syndrome (MRS), a rare genetic disorder caused by mutations in the RFX6 transcription factor gene. The study highlights the impact of these mutations on RFX6 function and discusses the multidisciplinary approach to treatment that has improved the prognosis for these patients. The findings suggest that further understanding of RFX6 function could lead to new therapeutic interventions for MRS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Olivier G. Polle, Antoine Delfosse, Manon Martin, Jacques Louis, Inge Gies, Marieke den Brinker, Nicole Seret, Marie-Christine Lebrethon, Thierry Mouraux, Laurent Gatto, Philippe A. Lysy
Summary: This study evaluated whether indexes of glycemic variability could overcome residual beta-cell secretion estimates in the longitudinal evaluation of partial remission in pediatric patients with new-onset type 1 diabetes. The combination of CGM metrics and clinical parameters revealed key clinical milestones of glucose homeostasis and remission status during the first year of type 1 diabetes in the pediatric cohort.
Editorial Material
Endocrinology & Metabolism
Willem Staels, Michael A. Levine
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Sofie Ryckx, Jean De Schepper, Philippe Giron, Ken Maes, Freya Vaeyens, Kaat Wilgenhof, Pierre Lefesvre, Caroline Ernst, Kim Vanderlinden, Daniel Klink, Frederik Hes, Jesse Vanbesien, Inge Gies, Willem Staels
Summary: We present a case of a 2.5-year-old boy with a pure androgen-secreting adrenocortical tumor, characterized by penile enlargement, pubic hair, frequent erections, and rapid linear growth. The diagnosis was confirmed through laboratory tests, medical imaging, and histology. Additionally, genetic testing revealed a pathogenic germline variant in the TP53 gene, confirming an underlying Li-Fraumeni syndrome.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Immunology
K. El Abdellati, A. Lucas, H. Perron, R. Tamouza, I. Nkam, J. -R. Richard, S. Fried, C. Barau, N. Djonouma, A. Pinot, S. Fourati, C. Rodriguez, V. Coppens, U. Meyer, M. Morrens, L. De Picker, M. Leboyer
Summary: This study aimed to investigate the SARS-CoV-2 seroprevalence, antibody titers, and cytokine concentrations in newly admitted or hospitalized psychiatric inpatients without a known history of COVID-19. The results showed that psychiatric patients had a significantly higher seroprevalence and antibody titers compared to hospital caregivers. The study highlights the importance of monitoring and mitigating exposure to infectious agents among psychiatric patients.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Hannes Syryn, Hannah Verdin, Julie Van De Velde, Marianne Becker, Cecile Brachet, Marieke den Brinker, Sylvia Depoorter, Julie Fudvoye, Daniel Klink, Philippe Lysy, Guy Massa, Nele Reynaert, Anne Rochtus, Willem Staels, Marlies Van Loocke, Martine Cools, Elfride De Baere
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Daniel Klink, Karl Logghe, Muriel Thomas, Mathieu Roelants, Katelijne Van Hoeck, Philippe Lysy, Marianne Becker, Willem Staels, Jean de Schepper
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Marianne Becker, Muriel Thomas, Cecile Brachet, Claudine Heinrichs, Hilde Dotremont, Karl Logghe, Kristina Casteels, Anne Rochtus, Daniel Klink, Martine Cools, Kathleen De Waele, Anne-Simone Parent, Guy Massa, Willem Staels, Inge Gies, Philippe Lysy, Dominique Beckers
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
E. Nauwynck, J. Vanbesien, J. De Schepper, I Gies, A. Van Leynseele, E. De Wachter, B. Hauser, W. Staels
Summary: Vitamin D intoxication is rare but increasing in children, especially those with cystic fibrosis, due to incorrect compounded preparations. This case report highlights the importance of considering vitamin D intoxication in children with cystic fibrosis presenting with specific symptoms and emphasizes the need for prompt treatment and regular monitoring of serum calcium and 25-hydroxyvitamin D levels.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
