Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kyeong Mi Kim, Hyun-Ju An, Sang-Hoon Kim, JuHee Kim, Changgon Sim, Jaemin Lee, Sin Hyung Park, Hyun Il Lee, Inseok Jang, Soonchul Lee
Summary: This study aimed to investigate the angiogenic potential of pericytes in diabetes-induced wounds. The results showed that pericytes enhanced vascularization and promoted wound healing. Therefore, pericyte transplantation may be a suitable treatment option for ischemic foot ulcers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Surgery
Mario A. Martinez-Jimenez, Samuel Kolosovas-Machuca, Francisco Alcocer, Luis Carlos Ortiz-Dosal, Mariana C. Gonzalez-Grijalva, Gibran A. Delsol-Revuelta, Francisco I. Gaitan-Gaona, Francisco J. Valadez-Castillo, Jose L. Ramirez-GarciaLuna
Summary: The topical administration of insulin glargine appears to be safe and promotes wound healing and tissue repair in nondiabetic patients with chronic venous ulcers.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Cell & Tissue Engineering
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Junger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schroder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Summary: This study suggests that GMP-manufactured ABCB5(+) dermal mesenchymal stem cells might be a safe adjunctive therapy for incurable diabetic foot ulcers. The results from mouse models and clinical trials demonstrate the efficacy of these stem cells in promoting wound healing and restoring blood perfusion.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Peripheral Vascular Disease
Qiqi Yu, Lei Liu, Xin Zhang, Hongfeng Chang, Shaobo Ma, Zhenhui Xie, Songtao Tang, Xinmin Ju, Huaqing Zhu, Bing Shen, Qiu Zhang
Summary: The study found that miR-221-3p promotes the viability, migration, and tube formation of endothelial cells, and it achieves this by decreasing the expression of HIPK2. Injection of miR-221-3p in diabetic mice promotes wound healing and inhibits the expression of HIPK2.
MICROVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Peikun Xin, Shuyan Han, Jun Huang, Conglai Zhou, Jiayuan Zhang, Xinru You, Jun Wu
Summary: Chronic diabetic wounds, characterized by long-term high levels of oxidative stress and blood sugar, present the biggest challenge in wound healing research. Edible natural biomaterials rich in terpenes, phenols, and flavonoids have shown potential as efficient antioxidants. Okra extract, selected as the main component of a wound dressing, displayed robust antioxidant properties, reducing reactive oxygen species and promoting wound healing in diabetic rats.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yifei Lu, Haisheng Li, Jing Wang, Mengyun Yao, Yuan Peng, Tengfei Liu, Zhou Li, Gaoxing Luo, Jun Deng
Summary: This study presents a novel approach of using a delivery system comprising living Lactococcus to bioengineer the wound microenvironment and enhance angiogenesis in a highly dynamic-temporal manner, aiming to drive rapid healing in chronic wounds.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Endocrinology & Metabolism
Rui Ding, Shicong Zhu, Xiaoyan Zhao, Rensong Yue
Summary: This meta-analysis evaluated the relationship between circulating levels of VEGFs and diabetic peripheral neuropathy (DPN). The results showed that VEGF levels were significantly increased in DPN patients compared to diabetic patients without DPN and healthy individuals. However, there was no evidence to support the correlation between VEGF levels and the risk of DPN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Nisha Maheshwari, Alessandro Marone, Mirella Altoe, Stephen H. K. Kim, Danielle R. Bajakian, Andreas H. Hielscher
Summary: This study validates the utility of the dynamic vascular optical spectroscopy system (DVOS) in assessing wound healing in peripheral arterial disease (PAD) patients one month after surgery, by recording hemodynamic response to predict long-term wound healing.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Dermatology
Lisa J. Gould, Dennis P. Orgill, David G. Armstrong, Robert D. Galiano, Paul M. Glat, Charles M. Zelen, Lawrence A. DiDomenico, Marissa J. Carter, William W. Li
Summary: This study demonstrated the benefits of processed microvascular tissue allograft in promoting wound closure, reducing time to healing, and improving local neuropathy in diabetic foot ulcer patients. Further exploration of its effects on regional neuropathy and perfusion endpoints is warranted.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Biochemistry & Molecular Biology
Shuofei Yang, ShuangShuang Wang, Liang Chen, Zheyu Wang, Jiaquan Chen, Qihong Ni, Xiangjiang Guo, Lan Zhang, Guanhua Xue
Summary: Diabetic foot ulcers (DFUs) are a common and deadly complication of diabetes. This study reveals that neutrophil extracellular traps can delay wound healing in diabetic foot ulcers through a specific pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Dermatology
Aakansha G. Goswami, Somprakas Basu, Vijay K. Shukla
Summary: The article reports a rare case of Marjolin's ulcer (MU) with rapid progression and multiple distant metastases. The authors highlight the importance of thorough metastatic workup and prognostication for MU at presentation, as well as the possibility of a rapidly progressive course after surgery leading to poor prognosis and mortality.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Dermatology
Aakansha Giri Goswami, Somprakas Basu, Vijay Kumar Shukla
Summary: Population aging, while an accomplishment, poses a significant challenge due to age-related skin changes and impaired wound healing in the elderly, leading to nonhealing chronic wounds. Multidisciplinary wound care strategies are necessary to address this issue, with a focus on developing diagnostic and therapeutic strategies to improve healing and understanding the complex biology of cellular senescence.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Dermatology
Somprakas Basu, Aakansha Giri Goswami, Lena Elizabeth David, Elizabeth Mudge
Summary: Psychological stress can cause physiological changes through the regulation of the neural, humoral, and immunological systems, impacting wound healing. Anxiety and fear before surgery can complicate wound healing, while physical stress in chronic wounds can lead to odor, pain, and isolation, affecting wound healing.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Dermatology
Ruhi Dixit, Naveen Kumar Chaudhary, Pradeep Kumar Mishra, Pradeep Srivastava, Satyanam Kumar Bhartiya, Arvind Pratap, Somprakas Basu, Vijay Kumar Shukla
Summary: The study found that trace elements were decreased in patients with chronic non-healing wounds, suggesting their role in wound healing.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Oncology
Vivek Srivastava, Aakansha Giri Goswami, Somprakas Basu, Vijay Kumar Shukla
Summary: Advancements in surgical techniques, chemoradiotherapy, and diagnostic imaging have greatly transformed the treatment of locally advanced rectal cancer. However, the challenge lies in finding the ideal combination of these advancements. This article explores the opportunities and obstacles in implementing different treatment approaches, as well as the current challenges and controversies surrounding multidisciplinary care. The ultimate goal is to improve patients' quality of life.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Review
Gastroenterology & Hepatology
Oshin Sharma, Dhiraj Mallik, Sukrati Ranjan, Poonam Sherwani, Navin Kumar, Somprakas Basu
Summary: Enterolithiasis is a rare medical disorder caused by intestinal stasis, commonly associated with tuberculosis, leading to small bowel obstruction that is difficult to diagnose. Mortality rate is relatively low in uncomplicated cases, but increases in patients with comorbid illness, significant bowel obstruction, and delayed diagnosis.
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2022)
Article
Dermatology
Bhavani Prasad Mahindrakar, Aakansha Giri Goswami, Farhanul Huda, Manisha Naithani, Somprakas Basu
Summary: This is an observational study that aims to monitor wound pH and surface temperature as predictors of wound healing in diabetic foot ulcers (DFU). The results showed that the wound pH decreased progressively and the wound temperature decreased as well, both corresponding to the improvement in DFU status, which may serve as valuable predictors of wound healing.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Dermatology
Tuhina Banerjee, Shailendra Rai, Aradhana Singh, Aakansha Giri Goswami, Mumtaz Ahmed Ansari, Arvind Pratap, Somprakas Basu, Vijay Kumar Shukla
Summary: This study investigates the association between macrophage function, IL-2 expression, and wound microflora in chronic DFUs. Low macrophage viability with predominance of Gram-negative flora was observed in DFU cases, and serum IL-2 levels were significantly lower in patients with DFUs. Elevated hemoglobin A1c levels were strongly associated with lower IL-2 levels and low macrophage viability.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Gastroenterology & Hepatology
Sanketh Edem, Aakansha Giri Goswami, Bibek Karki, Preeti Acharya, Udit Chauhan, Navin Kumar, Somprakas Basu
Summary: This case report highlights that superior mesenteric artery syndrome is a rare cause of proximal intestinal obstruction, which can occur in the early postoperative period and can be completely cured through medical management.
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2023)
Article
Emergency Medicine
Ankit Rai, Farhanul Huda, Praveen Kumar, Lena Elizabath David, S. Chezhian, Somprakas Basu, Sudhir Singh
Summary: This study evaluated predictors of outcomes in patients undergoing emergency laparotomy for perforation peritonitis. It found that hypotension, azotemia, coagulopathy, and delay in surgery were significant factors associated with postoperative mortality, while tachycardia, hypotension, azotemia, hypoalbuminemia, and preoperative coagulopathy were good predictors of the need for ICU admission.
ARCHIVES OF ACADEMIC EMERGENCY MEDICINE
(2022)
Meeting Abstract
Surgery
Farhanul Huda, Manisha Naithani, Bhavaniprasad Mahindrakar
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Emergency Medicine
Farhanul Huda, Sruthi Shasheendran, Somprakas Basu, Navin Kumar, Deepak Rajput, Sudhir K. Singh, Lena E. David, Chezhian Subramanian
Summary: This study aimed to identify the risk factors of surgical site infections (SSI) in patients who underwent elective laparotomy in a tertiary care hospital in India. The study found that preoperative serum total protein level and length of hospital stay were significantly associated with SSI, while age, gender, smoking, comorbidity, class of surgical wound, and preoperative albumin did not show any significant association. These findings can aid in formulating tailored antibiotic policies for the healthcare institution.
INTERNATIONAL JOURNAL OF BURNS AND TRAUMA
(2022)
Article
Anesthesiology
Abullais R. Gowda, Nishith Govil, Ajit Kumar, Deepak Singla, Mridul Dhar, Farhanul Huda
Summary: This study aimed to compare the efficacy of nebulized intraperitoneal ropivacaine with and without nalbuphine for post-operative pain relief in minimally invasive laparoscopic procedures. The study found that nebulized intraperitoneal ropivacaine, with or without nalbuphine, is more effective than placebo in relieving post-operative pain after laparoscopic cholecystectomy, without significant side effects.
TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
(2022)
