Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Junger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schroder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Summary: This study suggests that GMP-manufactured ABCB5(+) dermal mesenchymal stem cells might be a safe adjunctive therapy for incurable diabetic foot ulcers. The results from mouse models and clinical trials demonstrate the efficacy of these stem cells in promoting wound healing and restoring blood perfusion.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong Bi
Summary: Aberrant expressions of lncRNA H19 and miR-29b have been implicated in the complications of diabetes mellitus, specifically in diabetic foot ulcer (DFU). Upregulation of lncRNA H19 in DFU tissues competitively binds to miR-29b, leading to increased expression of FBN1, which enhances fibroblast proliferation and migration while inhibiting apoptosis, ultimately facilitating wound healing in DFU.
Article
Cardiac & Cardiovascular Systems
Kyeong Mi Kim, Hyun-Ju An, Sang-Hoon Kim, JuHee Kim, Changgon Sim, Jaemin Lee, Sin Hyung Park, Hyun Il Lee, Inseok Jang, Soonchul Lee
Summary: This study aimed to investigate the angiogenic potential of pericytes in diabetes-induced wounds. The results showed that pericytes enhanced vascularization and promoted wound healing. Therefore, pericyte transplantation may be a suitable treatment option for ischemic foot ulcers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xu Song, Yaqin Chen, Xiangxiu Chen, Xinghong Zhao, Yuanfeng Zou, Lixia Li, Xun Zhou, Mingyue Li, Dongmei Zhang, Gang Ye, Renyong Jia, Zhongqiong Yin
Summary: Tannic acid (TA) has been traditionally used for treating traumatic bleeding in China and has been shown to accelerate wound healing in rats. This study aims to uncover the mechanism behind TA's promotion of wound healing. Results show that TA enhances macrophage growth and inhibits the release of inflammatory cytokines by inhibiting the NF-κB/JNK pathway. TA also activates the Erk1/2 pathway, leading to increased expressions of growth factors and promoted fibroblast migration. Additionally, TA stimulates macrophages to secrete exosomes enriched in miR-221-3p, which enter fibroblasts and bind to the CDKN1b gene, promoting fibroblast migration. This study provides new insights into TA's acceleration of wound healing in the inflammatory and proliferative phases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Orthopedics
Huimin Huang, Wufei Zhu, Zongwei Huang, Dengze Zhao, Lu Cao, Xian Gao
Summary: Exosomes derived from ADSCs can alleviate the development of DFU by modulating the miR-204-3p/HIPK2 axis, providing a potential stem cell-based treatment strategy for DFU.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Multidisciplinary Sciences
Suriadi Jais, Kharisma Pratama
Summary: Indonesia is facing challenges in controlling the burden of diabetic foot ulcers, and a nursing care management approach is needed to accurately monitor wound healing progress. This literature review identified five assessment tools for chronic wounds, with the DMIST tool receiving sufficient rating for its predictive validity and responsiveness.
Article
Dermatology
Lisa J. Gould, Dennis P. Orgill, David G. Armstrong, Robert D. Galiano, Paul M. Glat, Charles M. Zelen, Lawrence A. DiDomenico, Marissa J. Carter, William W. Li
Summary: This study demonstrated the benefits of processed microvascular tissue allograft in promoting wound closure, reducing time to healing, and improving local neuropathy in diabetic foot ulcer patients. Further exploration of its effects on regional neuropathy and perfusion endpoints is warranted.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: This study developed a new method, PNO gel, for treating diabetic foot ulcer. The results demonstrated that PNO can accelerate wound healing, reduce inflammation, and promote angiogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, General & Internal
Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo
Summary: The study found that silver-releasing foam dressings were more effective in promoting wound healing of diabetic foot ulcers compared to silver-containing cream, particularly in the initial three weeks of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Liang Huang, Hua-An Cai, Ming-Sheng Zhang, Ruo-Yi Liao, Xing Huang, Feng-Dan Hu
Summary: The study found that Ginsenoside Rg1 can alleviate diabetic foot ulcers by increasing Sirt1 expression, reducing miR-489-3p levels, and promoting activation of the PI3K/AKT/eNOS signaling pathway.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Genetics & Heredity
Lei Yu, Jianxin Qin, Jiajun Xing, Zihao Dai, Tingting Zhang, Feng Wang, Jin Zhou, Xiaobai Zhang, Xia Chen, Yunjuan Gu
Summary: The morbidity of diabetes mellitus is increasing, leading to a growing economic burden of diabetic foot ulcers as a common complication. However, there is currently no standardized clinical treatment for this complication, and the efficacy of current treatments is unsatisfactory. Recent studies have shown that exosomes, which have low immunogenicity, high stability, and easy storage, promote diabetic wound healing through various pathways, such as promoting angiogenesis, collagen fiber deposition, and inhibiting inflammation. This article reviews the specific roles and mechanisms of different cell- or tissue-derived exosomes in wound healing and discusses the potential obstacles and solutions for future research on exosomes in the management of diabetic foot ulcers, aiming to provide novel insights and approaches for treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)