CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart

Transcription factor protein interactomes reveal genetic determinants in heart disease

(2022) Barbara Gonzalez-Teran et al.   CELL

Brahma safeguards canalization of cardiac mesoderm differentiation

(2022) Swetansu K. Hota et al.   NATURE

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

(2021) Krishnamoorthy Sreenivasan et al.   Stem Cell Reports

Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity

(2021) Joshua L. Justice et al.   Science Advances

Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation

(2021) Wei Shi et al.   DEVELOPMENTAL CELL

SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

(2020) Tianyun Hou et al.   NUCLEIC ACIDS RESEARCH

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

(2020) Lucas Farnung et al.   eLife

Association of NKX2-5, GATA4, and TBX5 polymorphisms with congenital heart disease in Egyptian children

(2019) Eman G. Behiry et al.   Molecular Genetics & Genomic Medicine

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation

(2019) Toshimi Yoshida et al.   GENES & DEVELOPMENT

CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis

(2019) Tessa Arends et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2-5 Protein–Protein Interaction Modulators

(2019) Mikael Jumppanen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conservation and divergence of protein pathways in the vertebrate heart

(2019) Joel D. Federspiel et al.   PLOS BIOLOGY

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers

(2019) Brynn N. Akerberg et al.   Nature Communications

Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies

(2018) Roxana Jalili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHD4 and the NuRD complex directly control cardiac sarcomere formation

(2018) Caralynn M. Wilczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

(2018) Veronika Ostapcuk et al.   NATURE

The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes

(2017) Haixin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Associations of GATA4 genetic mutations with the risk of congenital heart disease

(2017) Yanwei Zhang et al.   MEDICINE

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

(2017) Helen Hoffmeister et al.   NUCLEIC ACIDS RESEARCH

Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis

(2017) Leslie Kennedy et al.   PLoS Genetics

De Novo Mutations in CHD4 , an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms

(2016) Karin Weiss et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

(2016) Luis Luna-Zurita et al.   CELL

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

(2016) Pablo Gómez-del Arco et al.   Cell Metabolism

Electroporation of Cas9 protein/sgRNA into early pronuclear zygotes generates non-mosaic mutants in the mouse

(2016) Masakazu Hashimoto et al.   DEVELOPMENTAL BIOLOGY

The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation

(2016) Lauren Waldron et al.   DEVELOPMENTAL CELL

CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex

(2016) Jason K. K. Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules

(2016) W. Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

(2016) Alejandro Sifrim et al.   NATURE GENETICS

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development

(2015) K. M. Dorr et al.   DEVELOPMENT

Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification

(2015) Aoife O'Shaughnessy-Kirwan et al.   DEVELOPMENT

Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation

(2015) Lun Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

(2015) J. Homsy et al.   SCIENCE

Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: Functional characterization of a de novoTBX5mutation

(2014) Anwar Baban et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease

(2014) Aibin He et al.   Nature Communications

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

(2014) Yakov Chudnovsky et al.   Cell Reports

CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now

(2013) Aoife O’Shaughnessy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CASZ1 Promotes Vascular Assembly and Morphogenesis through the Direct Regulation of an EGFL7/RhoA-Mediated Pathway

(2013) Marta S. Charpentier et al.   DEVELOPMENTAL CELL

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

(2013) Anke Sparmann et al.   EMBO JOURNAL

A Gro/TLE-NuRD Corepressor Complex Facilitates Tbx20-Dependent Transcriptional Repression

(2013) Erin Kaltenbrun et al.   JOURNAL OF PROTEOME RESEARCH

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

(2013) Paola Picotti et al.   NATURE

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

(2013) H. Hosokawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

(2012) Aleksandra A. Watson et al.   JOURNAL OF MOLECULAR BIOLOGY

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

(2011) Ryota Terada et al.   CARDIOVASCULAR RESEARCH

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

(2011) Robyn E. Mansfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea

(2010) M. L. Scimone et al.   DEVELOPMENT

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

(2008) Meenakshi Maitra et al.   DEVELOPMENTAL BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY