Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts

Development of novel potent ligands for GPR85 , an orphan G protein‐coupled receptor expressed in the brain

(2022) Aya Sakai et al.   GENES TO CELLS

The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes

(2022) Dorian Dolanc et al.   Cells

Phoenixin-20 Prevents ox-LDL-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs): A Protective Implication in Atherosclerosis

(2021) Xiaolan Wei et al.   ACS Chemical Neuroscience

Constitutive G protein coupling profiles of understudied orphan GPCRs

(2021) Sumin Lu et al.   PLoS One

Characterization of the G protein-coupled receptor family SREB across fish evolution

(2021) Timothy S. Breton et al.   Scientific Reports

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

(2021) Thanigaimalai Pillaiyar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phoenixin as a New Target in the Development of Strategies for Endometriosis Diagnosis and Treatment

(2021) Karolina Iwona Kulinska et al.   Biomedicines

Blood and aqueous humor phoenixin, endocan and spexin in patients with diabetes mellitus and cataract with and without diabetic retinopathy

(2021) Fatih Celik et al.   PEPTIDES

Phoenixin-20 suppresses lipopolysaccharide-induced inflammation in dental pulp cells

(2020) Guohui Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits

(2020) Shofiul Azam et al.   Cells

A novel regulator of thirst behavior: phoenixin

(2020) Christopher J. Haddock et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes

(2020) Jian Wang et al.   INFLAMMATION RESEARCH

Phoenixin 20 promotes neuronal mitochondrial biogenesis via CREB–PGC-1α pathway

(2020) Yanwen Yang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish

(2020) Jithine Jayakumar Rajeswari et al.   Scientific Reports

Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes

(2020) Deeksha G. Chopra et al.   Scientific Reports

Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome

(2020) Natalia Kalamon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

phoenixin(smim20), a gene coding for a novel reproductive ligand, is expressed in the brain of adult zebrafish

(2020) R. Ceriani et al.   GENE EXPRESSION PATTERNS

Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis

(2019) Xuan Phuoc Nguyen et al.   REPRODUCTION

Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish

(2019) Anjali K. Nath et al.   FASEB JOURNAL

Novel regulator of vasopressin secretion: phoenixin

(2018) Silvia Gasparini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The G protein-coupled receptors deorphanization landscape

(2018) Céline Laschet et al.   BIOCHEMICAL PHARMACOLOGY

Phoenixin—A Pleiotropic Gut-Brain Peptide

(2018) Martha Schalla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes β -Arrestin 2 Recruitment

(2017) Nadine Dupuis et al.   MOLECULAR PHARMACOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Brain–gut–microbiota axis — mood, metabolism and behaviour

(2017) Timothy G. Dinan et al.   Nature Reviews Gastroenterology & Hepatology

Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173

(2016) Lauren M. Stein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

(2016) Toshihiro Yanai et al.   GENES TO CELLS

Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

(2016) Alice K. Treen et al.   MOLECULAR ENDOCRINOLOGY

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

(2016) Md. Shamim Hossain et al.   PLoS One

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis

(2015) Eriko Fujita-Jimbo et al.   Molecular Autism

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

(2015) Adam L. Martin et al.   PLoS One

Chronic activation of a designer Gq-coupled receptor improves β cell function

(2013) Shalini Jain et al.   JOURNAL OF CLINICAL INVESTIGATION

Phoenixin: A novel peptide in rodent sensory ganglia

(2013) R.-M. Lyu et al.   NEUROSCIENCE

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory

(2012) Qian Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Novel Reproductive Peptide, Phoenixin

(2012) G. L. C. Yosten et al.   JOURNAL OF NEUROENDOCRINOLOGY

Research Resource: RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome

(2012) Gregory M. Ku et al.   MOLECULAR ENDOCRINOLOGY

Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers

(2012) Eugenia Radulescu et al.   NEUROPSYCHOPHARMACOLOGY

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production

(2012) Gregory M. Ku et al.   PLoS Genetics

Oxidative Stress and Lectin-Like Ox-LDL-Receptor LOX-1 in Atherogenesis and Tumorigenesis

(2011) Jingjun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome

(2011) Chirag Patel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Sex influences on the neurobiology of learning and memory

(2009) J. M. Andreano et al.   LEARNING & MEMORY

Computational Influence of Adult Neurogenesis on Memory Encoding

(2009) James B. Aimone et al.   NEURON

Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study

(2008) Richard J.L. Anney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

(2008) Anthony J. Harmar et al.   NUCLEIC ACIDS RESEARCH

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan GPCR research

(2007) S Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY