Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer

Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study

(2015) Herbert I. Hurwitz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Smac mimetics as IAP antagonists

(2015) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells

(2014) Aiping Tian et al.   CANCER LETTERS

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC

(2014) Danielle F. Eytan et al.   LARYNGOSCOPE

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system

(2013) Jin-Qiu Chen et al.   ANALYTICAL BIOCHEMISTRY

The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

(2013) C. Krepler et al.   CLINICAL CANCER RESEARCH

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

(2013) Cinzia Scavullo et al.   LEUKEMIA RESEARCH

Capillary Isoelectric-Focusing Immunoassays to Study Dynamic Oncoprotein Phosphorylation and Drug Response to Targeted Therapies in Non–Small Cell Lung Cancer

(2013) Jin-Qiu Chen et al.   MOLECULAR CANCER THERAPEUTICS

Antitumor Activity of a Novel Homodimeric SMAC Mimetic in Ovarian Carcinoma

(2013) Laura Gatti et al.   MOLECULAR PHARMACEUTICS

Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired Chemoresistance

(2012) James W. Antoon et al.   Scientific Reports

Activation of NF- B Signaling by Inhibitor of NF- B Kinase   Increases Aggressiveness of Ovarian Cancer

(2010) L. Hernandez et al.   CANCER RESEARCH

Assessment of tumor response as a surrogate endpoint of survival in recurrent/platinum-resistant ovarian carcinoma: A Gynecologic Oncology Group study

(2010) Peter G. Rose et al.   GYNECOLOGIC ONCOLOGY

Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

(2009) Alice C Fan et al.   NATURE MEDICINE

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL