Article
Chemistry, Multidisciplinary
Yifei Yin, Xingwu Jiang, Liping Sun, Hongyan Li, Chunxia Su, Yan Zhang, Guang Xu, Xiaolong Li, Chongke Zhao, Yu Chen, Huixiong Xu, Kun Zhang
Summary: By utilizing continuous ultrasound-triggered inertial cavitation, a nanoplatform has been developed to accelerate ROS production, enhancing immunogenic cell death and inhibiting tumor growth, while alleviating the intratumoral immunosuppressive microenvironment.
Review
Oncology
Ting Wang, Wangrui Peng, Meng Du, Zhiyi Chen
Summary: Immunotherapy is a promising treatment for cancer, but its application is limited due to the suppression of tumor microenvironment and immune-related adverse events. Sonodynamic therapy (SDT) has been shown to effectively activate antitumor immunity and kill tumor cells. Various SDT therapies alone or in combination with other treatments have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper provides an overview of the research progress in SDT and nanotechnology, discusses the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and SDT-based immunotherapy for multimodal immunotherapy. The prospects and challenges of SDT-based therapies in cancer immunotherapy are also discussed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Naihan Huang, Along Qian, Yiming Zou, Miaoli Lin, Weilun Pan, Ming Chen, Wei Meng, Wenhua Zhang, Jinxiang Chen
Summary: Research aims to improve the immune response of radiation therapy (RT) by reshaping the immunosuppressive tumor microenvironment. A nanocomposite called UMP, constructed with core-shell UiO@Mn3O4, is used to reshape the TME and enhance immunogenic RT, inducing strong immunogenic cell death. This study is significant for TME reshaping and the development of cancer nanomedicine.
Article
Chemistry, Multidisciplinary
Jiao Zheng, Jiangchuan Sun, Jia Chen, Shenyin Zhu, Shuning Chen, Yujiao Liu, Lan Hao, Zhigang Wang, Shufang Chang
Summary: This study successfully fabricated phase-changeable core-shell nanoparticles, which have great potential for enhancing photoacoustic imaging. By combining chemotherapy and photo-sonodynamic therapy, the treatment strategy induced immunogenic cell death and significantly enhanced antitumor immunity, inhibiting the growth of ovarian cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Jiansen Huang, Jie He, Jie Wang, Yongcan Li, Zhigang Xu, Lei Zhang, Yuejun Kang, Peng Xue
Summary: By designing an ion homeostasis perturbator, self-defense mechanisms in cancer cells can be disrupted, leading to the impairment of mitochondrial function and providing insights in cancer therapy.
Article
Engineering, Biomedical
Ting Chen, Weiwei Zeng, Changjun Tie, Mian Yu, Huisong Hao, Yang Deng, Qianqian Li, Hairong Zheng, Meiying Wu, Lin Mei
Summary: "Translation: The article introduces a new nanoplatform for sonodynamic therapy that uses ultrasound to induce the production of reactive oxygen species. The nanoplatform, Au/BP@MS, shows an increase in the efficiency of reactive oxygen species generation in tumor tissues, leading to significant inhibition of tumor growth. Furthermore, the nanoplatform exhibits responsiveness and degradability in the tumor microenvironment, enhancing its potential for clinical theranostics."
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xiaodan Jiao, Lihong Sun, Wei Zhang, Junjie Ren, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: An oxygen-deficient zirconia-based nanoplatform, surface PEGylated and cyclic-Arg-Gly-Asp (cRGD) peptide functionalized, was designed for therapy-activated immunogenic cell death induction to enhance photothermal-augmented sonodynamic tumor elimination. This study demonstrates the potential of zirconia in tumor theranostics as a promising translational medicine.
Article
Chemistry, Multidisciplinary
Zhixiang Lu, Shuang Bai, Yonghe Jiang, Shuaiying Wu, Dazhuang Xu, Yulun Chen, Yulu Lan, Yibo An, Jingsong Mao, Xuan Liu, Gang Liu
Summary: This study presents the synthesis of a covalent organic framework with sonosensitive properties for the efficient loading of MnO2 and Poly(I:C). The developed nanomaterial is capable of reversing the reductive tumor microenvironment, generating magnetic resonance imaging signals, promoting reactive oxygen species production, inducing immunogenic cell death, and boosting the immune response. This multifunctional nanosystem represents a promising strategy for cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Min Zhang, Dayan Yang, Caihong Dong, Hui Huang, Guiying Feng, Qiqing Chen, Yuanyi Zheng, Hailin Tang, Yu Chen, Xiangxiang Jing
Summary: This study reports the fabrication of two-dimensional (2D) nanosonosensitizers/nanocatalysts for in situ generation of nanosonosensitizers, which respond to the tumor microenvironment. The nanosonosensitizers showed enhanced sonodynamic therapy (SDT) efficacy due to in situ generation of TiO2 nanosonosensitizers and enhanced ROS production. The combination of SDT and chemodynamic therapy demonstrated synergistic therapeutic effects both in vitro and in vivo.
Article
Engineering, Biomedical
Huaqing Chen, Lanlan Liu, Aiqing Ma, Ting Yin, Ze Chen, Ruijing Liang, Yuzhi Qiu, Mingbin Zheng, Lintao Cai
Summary: Sonodynamic therapy (SDT) shows promise for tumor treatment by activating immune responses and suppressing tumor growth. A multifunctional nanosonosensitizer system (FA-MnPs) has been developed, demonstrating deep-responsive SDT and immune activation, leading to tumor growth inhibition.
Article
Chemistry, Multidisciplinary
Yinmin Zhao, Jiahui Liu, Mengting He, Qi Dong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The construction of a smart therapeutic nanoplatform consisting of TiO2@Pt/GOx (TPG) allows for efficient sonodynamic therapy (SDT) and starvation therapy (ST), which lead to systemic tumor suppression and hypoxia alleviation in the tumor microenvironment. The optimized energy structure of TPG enables rapid generation of singlet oxygen and hydroxyl radicals. The accumulation of reactive oxygen species and glucose depletion facilitated by TPG result in oxidative damage and energy exhaustion of cancer cells, amplified by Pt-catalyzed oxygen self-supply. The combinatorial therapy also triggers immunogenetic cell death and subsequent suppression of distant tumors and metastasis through antitumor immunity.
Article
Materials Science, Multidisciplinary
Weidong Ni, Wenhao Zhu, Wen Wu, Jie Chen, Ping Ren, Fangfang Chen
Summary: Immunotherapy has become a powerful approach for tumor prevention and treatment. Nanoscale metal-organic framework (NMOF)-mediated immunogenic cell death (ICD) represents a promising strategy to activate the immune system and remodel the tumor immunosuppressive microenvironment into an antitumor immune microenvironment, showing potential for clinical applications.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Shuaiying Wu, Jianzhong Zhang, Jie Pan, Shuang Bai, Ziying Wang, Yulun Chen, Dazhuang Xu, Yibo An, Chao Liu, Chengchao Chu, Qixuan Dai, Lai Jiang, Zhixiang Lu, Gang Liu
Summary: This study developed a biomimetic nanoplatform that combines oxidative stress with genetic immunotherapy to enhance the therapeutic efficacy. The nanosystems effectively activate the oxidative stress-triggered immune response and inhibit PD-1/PD-L1 axis-mediated immune resistance.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shuang Liang, Jianjun Yao, Dan Liu, Lang Rao, Xiaoyuan Chen, Zhaohui Wang
Summary: Immunotherapy has made significant progress in cancer therapy, but it still faces challenges such as low response rates and immune-related adverse events. Sonodynamic therapy (SDT) has gained attention for treating deep-seated tumors and can trigger systemic anti-tumor immune response through immunogenic cell death. Nanotechnology has revolutionized SDT, leading to the development of innovative nanosonosensitizers and synergistic treatment modalities. This review summarizes the recent advances in cancer sonodynamic immunotherapy and explores how nanotechnology can enhance the anti-tumor immune response.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chunmei Zhang, Yandi Tan, Ju Huang, Xinyi Tang, Hongwei Xiang, Bin Shen, Chenchen Tang, Rui Li
Summary: The clinical success of immune checkpoint inhibitors in the treatment of metastatic cancer has been limited in pretreated metastatic breast cancer due to low immunogenicity and immunosuppressive tumor microenvironment. In this study, nanoliposomes were synthesized to deliver diclofenac and Mn (5,10,15,20-tetrakis(4-chlorophenyl)porphyrin) Cl to overcome these challenges. The results showed that this approach improved the antitumor effect of anti-PD1-based immunotherapy by activating T cells, inactivating regulatory T cells, and regulating immune cytokine levels.
MATERIALS & DESIGN
(2023)
