Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2070906
Keywords
Curcumin; stability; bioavailability; encapsulation systems; biological activity; clinical studies
Categories
Funding
- Zhejiang Provincial Key R&D Program of China [2021C02018]
- National Natural Science Foundation of China-Research Fund for International Scientists [32150410360]
- Zhejiang Provincial Natural Science Foundation of China [LR18C200002]
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Curcumin is a natural hydrophobic compound with various biological activities. Its limitations in application due to hydrophobicity and sensitivity can be overcome by encapsulation in different systems. Biopolymer-based nanoparticles and nano-gels are the best carriers, offering high encapsulation efficiency and stability against unfavorable conditions.
Curcumin (CUR) is a natural hydrophobic compound, which is available in turmeric rhizome. It has several bioactivities including antioxidant, anti-obesity, anti-diabetic, cardioprotective, anti-inflammatory, antimicrobial, anticancer, and other activities. Despite its medical and biological benefits, it is using in limitations because of its hydrophobicity and sensitivity. These unfavorable conditions further reduced the bioavailability (BA) and biological efficacy of CUR. This review summarizes the stability and BA of free- and encapsulated-CUR, as well as comprehensively discusses the potential biological activity of CUR-loaded various micro-/nano-encapsulation systems. The stability and BA of CUR can be improved via loading in different encapsulation systems, including nanoemulsions, liposomes, niosomes, biopolymer-based nanoparticles, nano-hydrogel, and others. Biopolymer-based nanoparticles (especially poly lactic-co-glycolic acid (PLGA), zein, and chitosan) and nano-gels are the best carriers for encapsulating and delivering CUR. Both delivery systems are suitable because of their excellent functional properties such as high encapsulation efficiency, well-stability against unfavorable conditions, and can be coated using other encapsulation systems. Based on available evidences, encapsulated-CUR exerted greater biological activities especially anticancer (breast cancer), antioxidant, antidiabetic, and neuroprotective effects.
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