Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study

Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study

(2021) Alyn Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

(2021) Hiroyuki Kai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Randomised trial of the P2X3 receptor antagonist sivopixant for refractory chronic cough

(2021) Akio Niimi et al.   EUROPEAN RESPIRATORY JOURNAL

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

(2020) Jaclyn A Smith et al.   Lancet Respiratory Medicine

Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough

(2020) Stuart Mazzone et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Airway Sensory Nerve Density is Increased in Chronic Cough

(2020) Clare O. Shapiro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterizing the Health-Related Quality of Life Burden of Overactive Bladder Using Disease-Specific Patient-Reported Outcome Measures: A Systematic Literature Review

(2019) Karissa M. Johnston et al.   ADVANCES IN THERAPY

The Effect of Gefapixant, a P2X3 antagonist, on Cough Reflex Sensitivity: A randomised placebo-controlled study

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

A Comprehensive Algorithm for Management of Neuropathic Pain

(2019) Daniel Bates et al.   PAIN MEDICINE

BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

(2019) Denis Garceau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

ATP cough challenge

(2019) Alyn Morice   PULMONARY PHARMACOLOGY & THERAPEUTICS

Druggable negative allosteric site of P2X3 receptors

(2018) Jin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?

(2017) Helen Elizabeth Fowles et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain

(2017) Ming Yuan et al.   International Journal of Nanomedicine

Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients

(2017) Ozen K. Basoglu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway

(2017) Shaojie Ding et al.   PLoS One

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

(2016) Rodica Pop-Busui et al.   DIABETES CARE

World Endometriosis Society consensus on the classification of endometriosis

(2016) Neil P. Johnson et al.   HUMAN REPRODUCTION

Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice

(2015) Aurelie Vandenbeuch et al.   JOURNAL OF PHYSIOLOGY-LONDON

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

Menstruation pulls the trigger for inflammation and pain in endometriosis

(2015) Alexis Laux-Biehlmann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

ESHRE guideline: management of women with endometriosis

(2014) G. A. J. Dunselman et al.   HUMAN REPRODUCTION

Purinergic signalling: from discovery to current developments

(2013) Geoffrey Burnstock   EXPERIMENTAL PHYSIOLOGY

Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point

(2013) Emma C.Y. Hilton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The difficult-to-treat, therapy-resistant cough: Why are current cough treatments not working and what can we do?

(2013) Lorcan McGarvey   PULMONARY PHARMACOLOGY & THERAPEUTICS

A taste for ATP: neurotransmission in taste buds

(2013) Sue C. Kinnamon et al.   Frontiers in Cellular Neuroscience

Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation

(2012) F.C. Prado et al.   NEUROPHARMACOLOGY

“Taste Strips” – A rapid, lateralized, gustatory bedside identification test based on impregnated filter papers

(2009) B. N. Landis et al.   JOURNAL OF NEUROLOGY

Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy

(2009) Keisuke Migita et al.   NEUROSCIENCE LETTERS

Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study-Part 1

(2008) KD Ballard et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Efficacy, Safety, and Tolerability of Pregabalin Treatment for Painful Diabetic Peripheral Neuropathy: Findings from seven randomized, controlled trials across a range of doses

(2008) R. Freeman et al.   DIABETES CARE

Prevalence, pathogenesis, and causes of chronic cough

(2008) Kian Fan Chung et al.   LANCET

Differences in characteristics among 1,000 women with endometriosis based on extent of disease

(2007) Ninet Sinaii et al.   FERTILITY AND STERILITY