Review
Chemistry, Medicinal
Lucia Merlino, Giulia D'Ovidio, Viviana Matys, Maria Grazia Piccioni, Maria Grazia Porpora, Roberto Senatori, Maria Federica Viscardi, Antonio Vitale, Carlo Della Rocca
Summary: This systematic review analyzed possible pharmacological and non-pharmacological treatments for genitourinary syndrome of menopause (GSM) in breast cancer survivors (BCS). The results showed that these treatments are effective for improving the quality of life and treatment outcomes in BCS with GSM.
Review
Geriatrics & Gerontology
Eduard Mension, Inmaculada Alonso, Camil Castelo-Branco
Summary: Breast cancer survivors often experience atrophic vaginitis due to persistent estrogen suppression treatments, but the use of local estrogen therapy is limited in these women due to treatment controversies. Non-hormonal treatments are the first-line therapy for vulvovaginal atrophy in this population, with concerns remaining about safety of alternative options like local estrogen, laser therapy, and local androgens.
Article
Medicine, General & Internal
Allison M. Quick, Andrew Hundley, Cynthia Evans, Julie A. Stephens, Bhuvaneswari Ramaswamy, Raquel E. Reinbolt, Anne M. Noonan, Jeffrey Bryan Van Deusen, Robert Wesolowski, Daniel G. Stover, Nicole Olivia Williams, Sagar D. Sardesai, Stephanie S. Faubion, Charles L. Loprinzi, Maryam B. Lustberg
Summary: Breast cancer survivors who received fractional CO2 laser therapy showed sustained improvement in sexual function two years after treatment completion, suggesting potential long-term benefit.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sine Jacobsen, Marianne Glavind-Kristensen, Anders Bonde Jensen, Axel Forman, Pinar Bor
Summary: The study aims to investigate the effectiveness of vaginal laser treatment in alleviating genitourinary syndrome of menopause in breast cancer survivors receiving adjuvant endocrine therapy, and explore the importance and long-term effects of repeated treatment. More randomized controlled trials are needed to determine the optimal treatment regimen and number of treatments.
Article
Geriatrics & Gerontology
Allison M. Quick, Travis Dockter, Jennifer Le-Rademacher, Ritu Salani, Catherine Hudson, Andrew Hundley, Shelby Terstriep, Lauren Streicher, Stephanie Faubion, Charles L. Loprinzi, Jenell S. Coleman, Karen C. Wang, Maryam Lustberg
Summary: The study aimed to evaluate the feasibility and efficacy of fractional CO2 laser therapy in gynecologic cancer survivors. Results showed preliminary evidence of improvement in sexual function with CO2 laser treatment compared to sham, indicating its potential benefits for survivors.
Review
Oncology
Daniel Maria Lubian Lopez
Summary: Breast cancer survivors often experience discomfort symptoms caused by vulvovaginal atrophy after receiving adjuvant therapy. While lifestyle modifications and nonhormonal treatments can help alleviate symptoms in most cases, other treatment options may be considered when these methods are ineffective. However, there is a lack of evidence for the safety and effectiveness of these treatments, calling for further research in this area.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Cristina Ros, Eduard Mension, Mariona Rius, Meritxell Munmany, Cristian De Guirior, Montserrat Espuna-Pons, Sonia Angles-Acedo, Camil Castelo-Branco
Summary: This pilot study aimed to evaluate a transvaginal ultrasound procedure for quantifying vaginal wall thickness and differentiating between healthy premenopausal women and postmenopausal women with genitourinary syndrome of menopause using ultra-low-level estrogen status. The results showed that the mean vaginal wall thickness in the postmenopausal group was significantly lower than that in the premenopausal group. Therefore, transvaginal ultrasound measurement can be a feasible objective technique for assessing genitourinary syndrome of menopause.
Article
Obstetrics & Gynecology
Laura Cucinella, Lara Tiranini, Chiara Cassani, Silvia Martella, Rossella E. Nappi
Summary: Genitourinary syndrome of menopause (GSM) is a common consequence of iatrogenic menopause or anti-estrogenic adjuvant therapies in breast cancer survivors (BCSs). Non-hormonal traditional treatments may be insufficient for managing severe GSM symptoms, and vaginal laser therapy has emerged as a promising alternative for women who are not suitable for or do not respond to hormonal management. This systematic review highlights the efficacy and safety of vaginal laser therapy in BCSs and identifies gaps in the current literature.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Review
Health Care Sciences & Services
Rossella E. Nappi, Silvia Martella, Francesca Albani, Chiara Cassani, Ellis Martini, Fabio Landoni
Summary: Genitourinary syndrome of menopause (GSM) is a chronic condition that affects women's urogenital health and sexual function. Symptoms are often not reported or underestimated, leading to underdiagnosis and undertreatment. Local estrogen therapy is the mainstay of vaginal treatments, but it may not be suitable for women with a history of hormone receptor positive cancer. Hyaluronic acid-based moisturizers may be a safe and effective non-hormonal treatment option, especially for women with a history of cancer.
Article
Nutrition & Dietetics
Maura Harrigan, Courtney McGowan, Annette Hood, Leah M. Ferrucci, ThaiHien Nguyen, Brenda Cartmel, Fang-Yong Li, Melinda L. Irwin, Tara Sanft
Summary: Dietary supplement use is common among breast cancer survivors, with a high prevalence of potential adverse interactions between prescribed endocrine therapy and dietary supplements.
Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Tao Wang, Yu-Yan Huang, Xian-Liang Liu, Alex Molassiotis, Li-Qun Yao, Si-Lin Zheng, Jing-Yu (Benjamin) Tan, Hou-Qiang Huang
Summary: This cross-sectional study in China focused on joint pain in breast cancer survivors receiving AI treatment. The study found that Chinese breast cancer survivors commonly experience joint pain, particularly in the knees. Factors such as poorer physical well-being/functioning, previous use of AI treatment, presence of osteoarthritis, and receiving physiotherapy were identified as correlates of greater severity of pain and pain interference.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Daniela Nahmias-Blank, Ofra Maimon, Amichay Meirovitz, Kim Sheva, Tamar Peretz-Yablonski, Michael Elkin
Summary: Postmenopausal, obese women have a higher risk of developing estrogen receptor-positive (ER+) breast tumors, which are resistant to therapies. The relationship between obesity and breast cancer differs in pre-menopausal and post-menopausal women. Elucidation of the molecular mechanisms behind obesity-related breast tumors is critical for disease prevention and treatment. Understanding these mechanisms could potentially prevent and intervene in the promotion of breast cancer associated with excess adiposity.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Cintia Pinheiro, Teresa Costa, Raira Amorim de Jesus, Raquel Campos, Rosa Brim, Alcina Teles, Andrea Vilas Boas, Patricia Lordelo
Summary: The study aimed to investigate the clinical response to non-ablative RF in patients with GSM, showing that most patients experienced a reduction in symptoms post-treatment, with a high level of satisfaction reported. The technique was well tolerated with no adverse effects, and positive effects on sexual and urinary function were observed.
Review
Medicine, General & Internal
Nida Jugulyte, Guoda Zukiene, Daiva Bartkeviciene
Summary: Breast cancer treatment can lead to earlier and more sudden menopausal symptoms, including genitourinary syndrome of menopause (GSM) which affects sexual function and quality of life. Treating GSM in breast cancer survivors is challenging due to ineffectiveness, contraindications, and low adherence to treatment. However, recent data suggest that vaginal laser therapy may be a feasible and safe option for alleviating GSM symptoms in breast cancer survivors. This narrative review focuses on the efficacy and safety of vaginal laser therapy for GSM in breast cancer patients.
MEDICINA-LITHUANIA
(2023)
Article
Urology & Nephrology
Ana Maria Alcalde, Maria Angeles Martinez-Zamora, Meritxell Gracia, Cristina Ros, Mariona Rius, Camil Castelo-Branco, Francisco Carmona
Summary: Women with deep infiltrating endometriosis (DIE) experience impaired quality of life, which may improve with the use of combined oral contraceptives (COCs) containing dienogest and ethinyl estradiol. Patients with DIE and associated adenomyosis (AD) have poorer sexual quality of life and more intense pain symptoms. After 12 months of treatment, both groups showed significant improvement in overall and sexual quality of life.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Marta Camacho, Camil Castelo-Branco
Summary: This study reports a rare phenotype of Kallmann syndrome in two sisters, characterized by reproductive disorders as well as a variety of nonreproductive disorders and neurological issues. These cases illustrate the heterogeneity of the clinical presentation of Kallmann syndrome and the difficulties in diagnosis.
REPRODUCTIVE SCIENCES
(2022)
Article
Pathology
Blanca Gonzalez-Farre, Joan E. Ramis-Zaldivar, Natalia Castrejon de Anta, Alfredo Rivas-Delgado, Ferran Nadeu, Julia Salmeron-Villalobos, Anna Enjuanes, Kennosuke Karube, Olga Balague, Francesc Cobo, Nicholas Kelleher, Ingrid Victoria, Luis Veloza, Cristina Teixido, Eva Gine, Monica Lopez-Guerra, Leticia Quintanilla-Martinez, Armando Lopez-Guillermo, Itziar Salaverria, Elias Campo
Summary: This study analyzed the clinicopathological and genetic alterations in 15 cases of IVLBCL using next-generation sequencing. The most frequently mutated genes were PIM1, MYD88, and CD79B, and PD-L1 expression was observed in some cases. The results emphasize the importance of mutations in B-cell receptor/nuclear factor-kappa B signaling and immune escape pathways in IVLBCL, and identify novel driver alterations. Extravascular dissemination may also be considered as part of the spectrum of IVLBCL.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Isaac Cebrecos, Eduard Mension, Maria Vidal, Francesco Schettini
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Hematology
Julia Salmeron-Villalobos, Natalia Castrejon-de-Anta, Pilar Guerra-Garcia, Joan Enric Ramis-Zaldivar, Monica Lopez-Guerra, Sara Mato, Dolors Colomer, Francisco Diaz-Crespo, Javier Menarguez, Marta Garrido-Pontnou, Mara Andres, Eugenia Garcia-Fernandez, Margarita Llavador, Gerard Frigola, Noelia Garcia, Blanca Gonzalez-Farre, Idoia Martin-Guerrero, Carmen Garrido-Colino, Itziar Astigarraga, Alba Fernandez, Jaime Verdu-Amoros, Soledad Gonzalez-Muniz, Berta Gonzalez, Veronica Celis, Elias Campo, Olga Balague, Itziar Salaverria
Summary: This study investigated the molecular features of pediatric monomorphic posttransplant lymphoproliferative disorders (PTLDs) and found shared pathogenesis between PTLD-BL and EBV-positive immunocompetent (IMC) BL.
Biographical-Item
Obstetrics & Gynecology
Camil Castelo-Branco
Article
Geriatrics & Gerontology
Cristina Ros, Eduard Mension, Mariona Rius, Meritxell Munmany, Cristian De Guirior, Montserrat Espuna-Pons, Sonia Angles-Acedo, Camil Castelo-Branco
Summary: This pilot study aimed to evaluate a transvaginal ultrasound procedure for quantifying vaginal wall thickness and differentiating between healthy premenopausal women and postmenopausal women with genitourinary syndrome of menopause using ultra-low-level estrogen status. The results showed that the mean vaginal wall thickness in the postmenopausal group was significantly lower than that in the premenopausal group. Therefore, transvaginal ultrasound measurement can be a feasible objective technique for assessing genitourinary syndrome of menopause.
Biographical-Item
Geriatrics & Gerontology
Camil Castelo-Branco
Article
Medicine, General & Internal
Eduard Mension, Inmaculada Alonso, Sonia Angles-Acedo, Cristina Ros, Jorge Otero, lvaro Villarino, Ramon Farre, Adela Saco, Naiara Vega, Natalia Castrejon, Jaume Ordi, Natalia Rakislova, Marta Tortajada, Isabel Matas, Silvia Gomez, Laura Ribera, Camil Castelo-Branco
Summary: Survivors of breast cancer with genitourinary syndrome of menopause (GSM) may experience more severe symptoms and new treatments such as vaginal laser therapy have emerged. This study aimed to assess the safety and efficacy of carbon dioxide (CO2) vs sham vaginal laser therapy in breast cancer survivors with GSM. The results showed that vaginal laser treatment was safe after 6 months of follow-up, but there were no statistically significant differences in efficacy between CO2 and sham laser therapy.
Editorial Material
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alex Gil, Natalia Castrejon-de-Anta, Isabel Vilaseca, Gerard Frigola, Elias Campo, Laura Oleaga
Summary: This report describes a case of Epstein-Barr virus-positive Inflammatory follicular dendritic cell/fibroblastic reticular cell tumour (EBV-IFDC/FRCT) occurring in the larynx, which is a rare occurrence. The authors used preoperative dual energy imaging techniques to assess the lesion, providing important information for clinical management.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)
