SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

(2021) Dandan Liang et al.   Nature Communications

Worldwide Survey of COVID-19 Associated Arrhythmias

(2021) Ellie J. Coromilas et al.   Circulation-Arrhythmia and Electrophysiology

Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity

(2021) Daisy A. Hoagland et al.   IMMUNITY

In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes

(2021) Justin Davis et al.   JCI Insight

The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication

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Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

(2021) Santosh Dhakal et al.   mBio

Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2

(2021) Liuliu Yang et al.   Stem Cell Reports

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

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Cell entry mechanisms of SARS-CoV-2

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

(2020) Masaki Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells

(2020) Hongyi Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Relative bradycardia in patients with COVID-19

(2020) Gioele Capoferri et al.   CLINICAL MICROBIOLOGY AND INFECTION

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

NODAL inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells

(2020) Sergey Yechikov et al.   Stem Cell Research

Electrocardiographic manifestations of COVID-19

(2020) Brit Long et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract

(2019) Makoto Sahara et al.   DEVELOPMENTAL CELL

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution

(2019) William R. Goodyer et al.   CIRCULATION RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

TBX18 transcription factor overexpression in human-induced pluripotent stem cells increases their differentiation into pacemaker-like cells

(2018) Armita M. Gorabi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Iron metabolism disorders in patients with hepatitis B-related liver diseases

(2018) Yan-Hang Gao et al.   World Journal of Clinical Cases

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

(2016) Stephanie I Protze et al.   NATURE BIOTECHNOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Short Stature Homeobox 2 (Shox2)-bone Morphogenetic Protein (BMP) Pathway Regulates Dorsal Mesenchymal Protrusion Development and Its Temporary Function as a Pacemaker during Cardiogenesis

(2014) Cheng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells

(2014) Julia Jeannine Jung et al.   Stem Cell Reports

Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia

(2013) Sandra Hoffmann et al.   BASIC RESEARCH IN CARDIOLOGY

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

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Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18

(2012) Nidhi Kapoor et al.   NATURE BIOTECHNOLOGY

The Role of the Funny Current in Pacemaker Activity

(2010) Dario DiFrancesco   CIRCULATION RESEARCH

Molecular Architecture of the Human Sinus Node

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