Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK‐3β/β‐catenin signaling pathway

Preclinical systematic review of ginsenoside Rg1 for cognitive impairment in Alzheimer’s disease

(2021) Hai-Yong Liang et al.   Aging-US

Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease

(2021) Yuqian Guo et al.   Molecular Medicine Reports

Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways

(2021) Yifeng Zhu et al.   Toxins

Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway

(2021) Weiqi Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathway

(2020) Alexandre Vallée et al.   Aging-US

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)

(2020) Elena Salobrar-García et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease

(2020) Han Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB

(2020) Shuai Liang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease

(2020) Yunying Yang et al.   Frontiers in Aging Neuroscience

Olesoxime improves cerebral mitochondrial dysfunction and enhances Aβ levels in preclinical models of Alzheimer's disease

(2020) Gunter P. Eckert et al.   EXPERIMENTAL NEUROLOGY

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation

(2020) Ning Jiang et al.   LIFE SCIENCES

Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer's-like disease in rats: Role of ERK, GSK-3β, and JNK signaling

(2020) Weam W. Ibrahim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

GSK3‐ARC/Arg3.1 and GSK3‐Wnt signaling axes trigger amyloid‐β accumulation and neuroinflammation in middle‐aged Shugoshin 1 mice

(2020) Chinthalapally V. Rao et al.   AGING CELL

Silencing of aquaporin1 activates the Wnt signaling pathway to improve cognitive function in a mouse model of Alzheimer's disease

(2020) Benshuai Yu et al.   GENE

Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases

(2020) Mar Carmona-Abellan et al.   NEUROLOGICAL SCIENCES

Mitoepigenetics and Neurodegenerative Diseases

(2019) Fabio Coppedè et al.   Frontiers in Endocrinology

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review

(2019) M. Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease

(2019) Xiao-Long Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tau immunotherapies for Alzheimer’s disease

(2019) Justin L. Hoskin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Deciphering the Role of WNT Signaling in Metabolic Syndrome–Linked Alzheimer’s Disease

(2019) Abuzer Ali et al.   MOLECULAR NEUROBIOLOGY

Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling

(2019) Xingsheng Shu et al.   NEUROPHARMACOLOGY

Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment

(2019) Shouchao Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer’s Disease: Stereochemistry and Biological Activity

(2018) Xiao-Long Hu et al.   ACS Chemical Neuroscience

Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson’s Disease

(2018) Dong-Mei Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gliadin effect on the oxidative balance and DNA damage: An in-vitro , ex - vivo study

(2018) Erika Monguzzi et al.   DIGESTIVE AND LIVER DISEASE

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer’s Disease Research?

(2018) Yu Fan et al.   JOURNAL OF ALZHEIMERS DISEASE

Reprogramming energetic metabolism in Alzheimer's disease

(2018) Alexandre Vallée et al.   LIFE SCIENCES

Ginsenoside Rg1 and Acori Graminei Rhizoma Attenuates Neuron Cell Apoptosis by Promoting the Expression of miR-873-5p in Alzheimer’s Disease

(2018) Ran Shi et al.   NEUROCHEMICAL RESEARCH

Optical and SPION-Enhanced MR Imaging Shows that trans-Stilbene Inhibitors of NF-κB Concomitantly Lower Alzheimer's Disease Plaque Formation and Microglial Activation in AβPP/PS-1 Transgenic Mouse Brain

(2018) Nathan O. Solberg et al.   JOURNAL OF ALZHEIMERS DISEASE

Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer’s disease induced by amyloid-β1–40 via activating the BDNF/TrkB signal pathway

(2018) Hong Zheng et al.   METABOLIC BRAIN DISEASE

Silencing of Long Noncoding RNA SOX21-AS1 Relieves Neuronal Oxidative Stress Injury in Mice with Alzheimer’s Disease by Upregulating FZD3/5 via the Wnt Signaling Pathway

(2018) Lu Zhang et al.   MOLECULAR NEUROBIOLOGY

Functions and dysfunctions of nitric oxide in brain

(2018) Pol Picón-Pagès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1–42-induced apoptosis due to prevention of endoplasmic reticulum stress

(2018) Weina Yang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Alzheimer’s Disease: It’s More Than Aβ

(2017) Joel N. Buxbaum   FASEB JOURNAL

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

(2017) Wen Fu et al.   Journal of Neuroinflammation

MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer’s disease

(2017) Xiaohui Ma et al.   NEUROSCIENCE LETTERS

High plasticity of axonal pathology in Alzheimer’s disease mouse models

(2017) Lidia Blazquez-Llorca et al.   Acta Neuropathologica Communications

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease

(2016) Jasmin Tischer et al.   GLIA

Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer’s disease

(2016) Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

(2016) Wei Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model

(2016) FENGLING LI et al.   Molecular Medicine Reports

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma

(2016) Alexandre Vallée et al.   Frontiers in Neuroscience

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

(2015) Ana Maria Marques Orellana et al.   Aging-US

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

(2015) Mustafa T. Ardah et al.   NEUROBIOLOGY OF DISEASE

Upregulation effects of Tanshinone IIA on the expressions of NeuN, Nissl body, and IκB and downregulation effects on the expressions of GFAP and NF-κB in the brain tissues of rat models of Alzheimer’s disease

(2015) Jian Li et al.   NEUROREPORT

Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model

(2015) Yingjia Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress

(2015) Xiao-Lin Yu et al.   Food & Function

Signaling pathway cross talk in Alzheimer’s disease

(2014) Juan A Godoy et al.   Cell Communication and Signaling

Neuroprotective Role of Novel Triazine Derivatives by Activating Wnt/β Catenin Signaling Pathway in Rodent Models of Alzheimer’s Disease

(2014) Anshuman Sinha et al.   MOLECULAR NEUROBIOLOGY

Effects of Ginsenoside Rg1 on the Expression of Toll-Like Receptor 3, 4 and Their Signalling Transduction Factors in the NG108-15 Murine Neuroglial Cell Line

(2014) Bao-Sheng Zhao et al.   MOLECULES

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Wnt signaling: Role in LTP, neural networks and memory

(2013) Carolina A. Oliva et al.   AGEING RESEARCH REVIEWS

Ginsenoside Rg1 Attenuates Oligomeric Aβ1-42-Induced Mitochondrial Dysfunction

(2012) Tianwen Huang et al.   Current Alzheimer Research

MicroRNAs in Alzheimer's disease

(2012) Charlotte Delay et al.   NEUROBIOLOGY OF DISEASE

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From tau phosphorylation to tau aggregation: what about neuronal death?: Figure 1

(2010) Luc Buée et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

(2010) K N Manolopoulos et al.   MOLECULAR PSYCHIATRY

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation

(2010) Qian Liu et al.   NEUROCHEMISTRY INTERNATIONAL

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen–glucose deprivation-induced apoptosis in primary rat cortical neuronal cells

(2008) Hyunju Chung et al.   JOURNAL OF ENDOCRINOLOGY

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE