IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

(2022) Dan Yu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genetic variants in m6A regulators are associated with gastric cancer risk

(2021) Xiaowei Wang et al.   ARCHIVES OF TOXICOLOGY

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

(2021) Botai Li et al.   Nature Communications

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification

(2021) Pingfu Hou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma

(2020) Shuo Chen et al.   Cancer Cell International

Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2

(2020) Yang Yang et al.   OncoTargets and Therapy

Gastric cancer

(2020) Elizabeth C Smyth et al.   LANCET

SHROOM2 inhibits tumor metastasis through RhoA–ROCK pathway-dependent and -independent mechanisms in nasopharyngeal carcinoma

(2019) Jing Yuan et al.   Cell Death & Disease

Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway

(2019) Yifan Wang et al.   BIOSCIENCE REPORTS

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

(2019) Shoumin Zhu et al.   ONCOGENE

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway

(2019) Xiaodong Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

(2019) Yun Wang et al.   Molecular Cancer

Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-κB pathway

(2018) Jingjing Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis

(2018) Catrin Youssif et al.   EMBO Molecular Medicine

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

(2018) Hamish Campbell et al.   Nature Communications

Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries

(2018) Hongmei Zeng et al.   Lancet Global Health

Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia

(2017) Zheng Chen et al.   GENES CHROMOSOMES & CANCER

IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer

(2017) Sonja M. Kessler et al.   Oncotarget

The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1

(2017) Julien Daubriac et al.   Oncotarget

IGF1R and c-met as therapeutic targets for colorectal cancer

(2016) Hajar Shali et al.   BIOMEDICINE & PHARMACOTHERAPY

Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression

(2016) Jung Hwan Yoon et al.   Gastric Cancer

Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma

(2016) Ahmad Barghash et al.   Oncotarget

MiR-31 Regulates Rho-Associated Kinase-Myosin Light Chain (ROCK-MLC) Pathway and Inhibits Gastric Cancer Invasion: Roles of RhoA

(2016) Zhuo Chen et al.   MEDICAL SCIENCE MONITOR

Effects of IGF2BP2, KCNQ1 and GCKR polymorphisms on clinical outcome in metastatic gastric cancer treated with EOF regimen

(2015) Xin Liu et al.   PHARMACOGENOMICS

IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype

(2015) S M Kessler et al.   Cell Death & Disease

Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer

(2014) Mariusz Gryko et al.   POLISH JOURNAL OF PATHOLOGY

Internal mRNA Methylation Finally Finds Functions

(2014) T. W. Nilsen   SCIENCE

Inflammation-related factors predicting prognosis of gastric cancer

(2014) Wen-Jun Chang   WORLD JOURNAL OF GASTROENTEROLOGY

Humoral Autoimmune Response to IGF2 mRNA-Binding Protein (IMP2/p62) and Its Tissue-Specific Expression in Colon Cancer

(2013) W. Liu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis

(2012) Zhizhong Li et al.   DEVELOPMENTAL CELL

RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility

(2011) Tasuku Matsuoka et al.   CLINICAL & EXPERIMENTAL METASTASIS

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin

(2009) Y. Adachi et al.   CARCINOGENESIS