CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity

Biological insights from the direct measurement of purine release

(2021) Nicholas Dale   BIOCHEMICAL PHARMACOLOGY

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

(2021) Aarti Jagannath et al.   Nature Communications

Keep an eye on adenosine: Its role in retinal inflammation

(2020) Ana Raquel Santiago et al.   PHARMACOLOGY & THERAPEUTICS

Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ecto-Nucleotidases CD73 and CD39

(2020) Jenna L. Jeffrey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Fluorescent Probes for Ecto-5′-nucleotidase (CD73)

(2020) Constanze C. Schmies et al.   ACS Medicinal Chemistry Letters

Adenosine metabolism in the vascular system

(2020) Gennady G. Yegutkin   BIOCHEMICAL PHARMACOLOGY

Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now

(2020) Herbert Zimmermann   Purinergic Signalling

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

(2019) Julian Zeiner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

(2019) Anna Junker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

(2019) Weizhe Li et al.   Nature Protocols

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

(2019) Madhvi Menon et al.   Nature Communications

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing

(2019) Jacob S. Heng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

(2018) Yoko Okunuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal microglia – A key player in healthy and diseased retina

(2018) Gurugirijha Rathnasamy et al.   PROGRESS IN NEUROBIOLOGY

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

(2018) Isha Akhtar‐Schäfer et al.   EMBO Molecular Medicine

Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids

(2018) Giuliana Gagliardi et al.   Stem Cell Reports

Microglia and the Purinergic Signaling System

(2018) Stefano Calovi et al.   NEUROSCIENCE

ProMoIJ: A new tool for automatic three-dimensional analysis of microglial process motility

(2017) Iñaki Paris et al.   GLIA

Retinal A2A and A3 adenosine receptors modulate the components of the rat electroretinogram

(2017) GUDMUNDUR JONSSON et al.   VISUAL NEUROSCIENCE

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

(2017) Zhiping Liu et al.   Nature Communications

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy

(2016) Sirpa Loukovaara et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ocular Purine Receptors as Drug Targets in the Eye

(2016) Kenneth A. Jacobson et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters

(2015) Eric A. Newman   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel from Embryonic Stem Cell-Derived Self-Forming Retina

(2015) Jorn Lakowski et al.   STEM CELLS

Contribution of retinal ganglion cells to the mouse electroretinogram

(2014) Benjamin J. Smith et al.   DOCUMENTA OPHTHALMOLOGICA

Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

(2014) Julie Sanderson et al.   EXPERIMENTAL EYE RESEARCH

Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway

(2014) Puneet Sodhi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extracellular ATP Hydrolysis Inhibits Synaptic Transmission by Increasing pH Buffering in the Synaptic Cleft

(2014) Rozan Vroman et al.   PLOS BIOLOGY

Adenosine, adenosine receptors and glaucoma: An updated overview

(2013) Yisheng Zhong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Adenosine and Dopamine Receptors Coregulate Photoreceptor Coupling via Gap Junction Phosphorylation in Mouse Retina

(2013) H. Li et al.   JOURNAL OF NEUROSCIENCE

Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability

(2013) Dao-Yi Yu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease

(2012) Joanna Kur et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Purinergic signaling involved in Müller cell function in the mammalian retina

(2011) Antje Wurm et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish

(2009) María Jimena Ricatti et al.   SYNAPSE

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

(2008) Gennady G. Yegutkin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evidence for a calcification process in the trabecular meshwork

(2008) Teresa Borrás et al.   EXPERIMENTAL EYE RESEARCH