Article
Engineering, Biomedical
Tao Yu, Yunpin Hu, Wenbao He, Yong Xu, Anqi Zhan, Kai Chen, Mingxiang Liu, Xiufeng Xiao, Xiangyang Xu, Qian Feng, Liangfu Jiang
Summary: Although hydrogels have been widely studied for their biocompatibility and plasticity, they have limitations in bone tissue engineering due to their inadequate mechanical properties and lack of osteogenic activity. To overcome these limitations, a new alendronate (ALN)-Ca2+/Mg2+ doped hydrogel was developed based on a mechanically resilient host-guest macromer (HGM) hydrogel. The upgraded CMS hydrogel exhibited improved mechanical properties and promoted bone cell proliferation and differentiation. In vivo experiments demonstrated that the CMS hydrogel had better bone regeneration ability compared to the HGM hydrogel. The updated CMS hydrogel shows significant potential for bone tissue engineering applications.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Wenda Wang, Zicheng Zeng, Li Xiang, Cong Liu, Diana Diaz-Dussan, Zunguo Du, Anika B. Asha, Wenshuai Yang, Yi-Yang Peng, Mingfei Pan, Ravin Narain, Jifang Liu, Hongbo Zeng
Summary: An injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly has been developed for gastric perforation healing. The hydrogel dressing possesses sensitive thermo-responsibility, injectability, antibiofouling property, simplifying surgical procedures, reducing postoperative complications, and enhancing the healing process. This work provides valuable insights for the development of biological environment-adaptive functional materials for biomedical applications.
Article
Pharmacology & Pharmacy
Mohamed M. Abdelghafour, Agota Deak, Tamas Kiss, Gabor Katona, Rita Ambrus, Aniko Keller-Pinter, Istvan Szatmari, Diana Szabo, Laszlo Rovo, Laszlo Janovak, Maria Budai-Szfics, Mint Lorinczi
Summary: A two-component injectable hydrogel was developed for the encapsulation and prolonged release of an antimuscular atrophy drug. The hydrogel exhibited controlled release characteristics and increased adhesion properties, making it a potential candidate for drug delivery systems.
Article
Engineering, Biomedical
Jinghua Luo, Xueshuang Shi, Liming Li, Zan Tan, Feng Feng, Jun Li, Mao Pang, Xiaoying Wang, Liumin He
Summary: The developed FC/FI hybrid hydrogel with injectable and self-healing properties promotes neural regeneration and modulates inflammation, contributing to spinal cord injury repair.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jiahui He, Zixi Zhang, Yutong Yang, Fenggang Ren, Jipeng Li, Shaojun Zhu, Feng Ma, Rongqian Wu, Yi Lv, Gang He, Baolin Guo, Dake Chu
Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.
NANO-MICRO LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Nabanita Mukherjee, Satyajit Ghosh, Jayita Sarkar, Rajsekhar Roy, Debasmita Nandi, Surajit Ghosh
Summary: The inherent mechanical strength and customizable physicochemical properties of amyloids allow for the rational design and synthesis of biomaterials for specific purposes. However, the significant antimicrobial efficacy of these materials has been largely overlooked. This research provides insight into the relationship between self-assembly and antimicrobial activity of amyloid-derived peptide amphiphiles, leading to the development of novel antimicrobial materials with excellent wound healing properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: Developing a biocompatible and multifunctional adhesive hydrogel for wound healing is a highly anticipated clinical application. In this paper, a novel natural biopolymer-derived hydrogel based on aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) is presented. The hydrogel has excellent self-healing ability and shear thinning behavior, and can be injected conveniently through a needle. The physiochemical properties of the hydrogel can be controlled by regulating the concentrations of OGG. In addition, the hydrogel can adhere tightly to tissues and promote wound repair by encapsulating vascular endothelial growth factor (VEGF).
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: This paper presents a biocompatible and multifunctional adhesive hydrogel based on oxidized guar gum and carboxymethyl chitosan for promoting wound healing. The hydrogel has self-healing ability and shear thinning behavior, allowing it to be easily injected. Its physiochemical properties can be controlled by regulating the concentrations of the hydrogel components. Additionally, the hydrogel exhibits strong adhesion to tissues at physiological temperature.
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Instruments & Instrumentation
Rishikesh Deka, Plabita Boruah, Asadulla Asraf Ali, Rupjyoti Dutta, Parikshit Gogoi, Jayanta K. Sarmah
Summary: A novel shear-thinning cross-linked hydrogel has been developed for controlled release of silver nanoparticles and antibacterial activity.
SMART MATERIALS AND STRUCTURES
(2022)
Article
Polymer Science
Dongmei Liu, Susu Zhao, Yujie Jiang, Chuanhui Gao, Yumin Wu, Yuetao Liu
Summary: Hydrogels with good biocompatibility and moisture-preserving properties can be used as medical materials for wound dressings. By copolymerizing blood serum albumin (BSA) with various monomers, double network hydrogels were synthesized, which significantly improved the mechanical strength of natural protein-based hydrogels and showed good biocompatibility and stable drug release properties. In vitro evaluation in a mouse skin incision model demonstrated that the hydrogels had a high wound closure effect, offering a feasible strategy for rapid skin wound healing.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Min Nie, Bin Kong, Guopu Chen, Ying Xie, Yuanjin Zhao, Lingyun Sun
Summary: The novel MSCs-laden injectable self-healing hydrogel developed for SSc treatment shows promising results in promoting MSCs proliferation, increasing cellular half-life, promoting angiopoiesis, and inhibiting fibrosis in disease model mice.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Kai-Yi Chang, Ying-Nien Chou, Wei-Yu Chen, Chuh-Yean Chen, Hong-Ru Lin
Summary: This study develops a multi-functional hydrogel with a dual injection system based on the adhesive and self-healing properties of the byssus excretion found in mussels. The hydrogel has high strength, temperature sensitivity, good adhesion, self-healing properties, and antibacterial resistance. It can be used for deep wound treatment and improvement of traditional wound dressings.
Article
Engineering, Environmental
Qiuning Yu, Shicun Jin, Shaochi Wang, Huining Xiao, Yanteng Zhao
Summary: In this study, a multifunctional hydrogel was developed for spinal cord injury repair. The hydrogel possessed injectable, electroconductive, adhesive, and self-healing properties and was proven to accelerate spinal cord regeneration in a rat model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)