Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma

Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival

(2021) Erin E. Crotty et al.   JOURNAL OF NEURO-ONCOLOGY

Regulation of lipid‐induced macrophage polarization through modulating PPAR‐γ activity affects hepatic lipid metabolism via TLR4/NF‐κB signaling pathway

(2020) Hui‐Min Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Medulloblastoma: Molecular understanding, treatment evolution, and new developments

(2020) Xiaohua Liu et al.   PHARMACOLOGY & THERAPEUTICS

Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway

(2020) Victor Delprat et al.   Scientific Reports

Aggressive Medulloblastoma-Derived Exosomal miRNAs Promote In Vitro Invasion and Migration of Tumor Cells Via Ras/MAPK Pathway

(2020) Liang-Yi Zhu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice

(2020) Yinqiang Sui et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia

(2020) Jayakumar Vadakekolathu et al.   Science Translational Medicine

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

(2020) Astrid De Boeck et al.   Nature Communications

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

(2020) Yuchen Li et al.   Stem Cell Research & Therapy

MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway

(2019) Yongxiang Yang et al.   NEUROCHEMICAL RESEARCH

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

(2019) Jung Eun Park et al.   ONCOGENE

Resolving medulloblastoma cellular architecture by single-cell genomics

(2019) Volker Hovestadt et al.   NATURE

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

(2019) Irene Mattiola et al.   NATURE IMMUNOLOGY

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

(2019) Victor Maximov et al.   Nature Communications

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9

(2019) Dong-Mei Wu et al.   Molecular Therapy-Nucleic Acids

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

(2019) Mingyu Qian et al.   ONCOGENE

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas

(2018) Chanhee Lee et al.   BMC CANCER

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

SNCA , a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis

(2018) Yong-Xiao Li et al.   CANCER SCIENCE

MiR-27-3p regulates TLR2/4-dependent mouse alveolar macrophage activation by targetting PPARγ

(2018) Dan Wang et al.   CLINICAL SCIENCE

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

(2018) Issei S. Shimada et al.   Cell Reports

Subgroup-specific immune and stromal microenvironment in medulloblastoma

(2018) Michael Bockmayr et al.   OncoImmunology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells

(2017) Ratna Sanyal et al.   IMMUNOLOGY AND CELL BIOLOGY

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

(2017) Edward C Schwalbe et al.   LANCET ONCOLOGY

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

(2017) Manav Korpal et al.   Nature Communications

Gene expression markers of Tumor Infiltrating Leukocytes

(2017) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma

(2016) Yongxiao Li et al.   JOURNAL OF NEURO-ONCOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma

(2015) Katherine Tech et al.   CANCER LETTERS

SHH inhibitors for the treatment of medulloblastoma

(2015) Ayman Samkari et al.   Expert Review of Neurotherapeutics

Smoothened Inhibitors in Sonic Hedgehog Subgroup Medulloblastoma

(2015) Katherine J. Ransohoff et al.   JOURNAL OF CLINICAL ONCOLOGY

SHH inhibitors for the treatment of medulloblastoma

(2015) Ayman Samkari et al.   Expert Review of Neurotherapeutics

Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas

(2014) A. S. Margol et al.   CLINICAL CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma

(2014) S N Brun et al.   ONCOGENE

Characterization of Distinct Immunophenotypes across Pediatric Brain Tumor Types

(2013) A. M. Griesinger et al.   JOURNAL OF IMMUNOLOGY

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

(2012) Bobby Bhatia et al.   ACTA NEUROPATHOLOGICA

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

HPV16 and BPV1 Infection Can Be Blocked by the Dynamin Inhibitor Dynasore

(2009) Cynthia Y Abban et al.   AMERICAN JOURNAL OF THERAPEUTICS

Activation of PPARα inhibits IGF‐I‐mediated growth and survival responses in medulloblastoma cell lines

(2008) Katarzyna Urbanska et al.   INTERNATIONAL JOURNAL OF CANCER