NEDD4L Protein Catalyzes Ubiquitination of PIK3CA Protein and Regulates PI3K-AKT Signaling

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L

(2014) Albert Escobedo et al.   STRUCTURE

Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer

(2013) Hiroyuki Sakashita et al.   ANNALS OF SURGICAL ONCOLOGY

Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma

(2013) Yusuke Kito et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

(2013) Shafi Kuchay et al.   NATURE CELL BIOLOGY

NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling

(2013) Jarred P. Tanksley et al.   PLoS One

Down-regulation of Nedd4L is Associated with the Aggressive Progression and Worse Prognosis of Malignant Glioma

(2012) S. He et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

(2011) Tina L. Yuan et al.   CURRENT BIOLOGY

Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient

(2011) Chengcheng Gao et al.   MEDICAL ONCOLOGY

Transcription alterations of members of the ubiquitin–proteasome network in prostate carcinoma

(2010) O J C Hellwinkel et al.   PROSTATE CANCER AND PROSTATIC DISEASES

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

(2009) B Yang et al.   CELL DEATH AND DIFFERENTIATION

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

(2009) Yasushi Saeki et al.   EMBO JOURNAL

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane

(2009) D. Mandelker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

(2008) H. Yamamoto et al.   CANCER RESEARCH

Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

(2008) X.Y. Hu et al.   EJSO

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE