Biofilm control by interfering with c-di-GMP metabolism and signaling

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

(2021) Jens Bo Andersen et al.   npj Biofilms and Microbiomes

Microbial deterioration and sustainable conservation of stone monuments and buildings

(2020) Xiaobo Liu et al.   Nature Sustainability

Optogenetic Modulation of a Catalytic Biofilm for the Biotransformation of Indole into Tryptophan

(2019) Yidan Hu et al.   ChemSusChem

Water is a critical factor in evaluating and assessing microbial colonization and destruction of Angkor sandstone monuments

(2018) Xiaobo Liu et al.   INTERNATIONAL BIODETERIORATION & BIODEGRADATION

Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios

(2017) Alyssa S. Ball et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

(2017) Ranita Roy et al.   Virulence

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB

(2017) Mustafa Fazli et al.   MicrobiologyOpen

Geomicrobiology of the built environment

(2017) Geoffrey Michael Gadd   Nature Microbiology

Influence of 3-Chloroaniline on the Biofilm Lifestyle of Comamonas testosteroni and Its Implications on Bioaugmentation

(2016) Yichao Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa

(2016) Amy E. Baker et al.   JOURNAL OF BACTERIOLOGY

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria

(2016) Donald C. Sheppard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the activator ofK. pneumoniabiofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding

(2016) Maria A. Schumacher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching

(2016) L. Xu et al.   Science Signaling

Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative

(2016) Yue Zheng et al.   Chemical Science

Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain

(2016) Yu-Chuan Wang et al.   Nature Communications

SiaA/D Interconnects c-di-GMP and RsmA Signaling to Coordinate Cellular Aggregation of Pseudomonas aeruginosa in Response to Environmental Conditions

(2016) Brendan Colley et al.   Frontiers in Microbiology

A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching

(2016) L. Xu et al.   Science Signaling

Involvement in Denitrification is Beneficial to the Biofilm Lifestyle of Comamonas testosteroni: A Mechanistic Study and Its Environmental Implications

(2015) Yichao Wu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli

(2015) Alberto Reinders et al.   JOURNAL OF BACTERIOLOGY

Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli: TABLE 1

(2015) Regine Hengge et al.   JOURNAL OF BACTERIOLOGY

In SilicoDiscovery andIn VitroValidation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

(2015) Silvia Fernicola et al.   JOURNAL OF BACTERIOLOGY

Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms

(2015) Shan-Ho Chou et al.   JOURNAL OF BACTERIOLOGY

Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers

(2015) Regine Hengge et al.   JOURNAL OF BACTERIOLOGY

Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase

(2015) Silvia Fernicola et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

(2015) C. Lori et al.   NATURE

Characterization of the Xylella fastidiosa PD1671 Gene Encoding Degenerate c-di-GMP GGDEF/EAL Domains, and Its Role in the Development of Pierce’s Disease

(2015) Luciana Cursino et al.   PLoS One

Oligoribonuclease is a central feature of cyclic diguanylate signaling inPseudomonas aeruginosa

(2015) Dorit Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligoribonuclease is the primary degradative enzyme for pGpG inPseudomonas aeruginosathat is required for cyclic-di-GMP turnover

(2015) Mona W. Orr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ fromPseudomonas aeruginosa

(2015) Bruno Y. Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

(2015) Song Lin Chua et al.   Scientific Reports

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems

(2015) Kevin G. Roelofs et al.   PLoS Pathogens

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

Tetrameric c-di-GMP Mediates Effective Transcription Factor Dimerization to Control Streptomyces Development

(2014) Natalia Tschowri et al.   CELL

Quorum Sensing Inhibitors as Anti-Biofilm Agents

(2014) Gilles Brackman et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile

(2014) Eric Bordeleau et al.   JOURNAL OF BACTERIOLOGY

Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP

(2014) Amit Sundriyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and polar sequestration of PopA, a c-di-GMP effector protein involved inCaulobacter crescentuscell cycle control

(2014) Shogo Ozaki et al.   MOLECULAR MICROBIOLOGY

Diguanylate cyclase NicD-based signalling mechanism of nutrient-induced dispersion byPseudomonas aeruginosa

(2014) Ankita Basu Roy et al.   MOLECULAR MICROBIOLOGY

The Degenerate EAL-GGDEF Domain Protein Filp Functions as a Cyclic di-GMP Receptor and Specifically Interacts with the PilZ-Domain Protein PXO_02715 to Regulate Virulence in Xanthomonas oryzae pv. oryzae

(2014) Fenghuan Yang et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP

(2014) Jacob L W Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Anti-biofilm agents: recent breakthrough against multi-drug resistantStaphylococcus aureus

(2014) Pooi Y. Chung et al.   Pathogens and Disease

High-Throughput Screening Using the Differential Radial Capillary Action of Ligand Assay Identifies Ebselen As an Inhibitor of Diguanylate Cyclases

(2013) Ori J. Lieberman et al.   ACS Chemical Biology

Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development

(2013) Karthik Sambanthamoorthy et al.   BIOFOULING

Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2′-F-c-di-GMP

(2013) Jie Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States

(2013) Andreas Winkler et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

(2013) Dom Bellini et al.   MOLECULAR MICROBIOLOGY

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

(2013) C. Baraquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase

(2013) Franziska Zähringer et al.   STRUCTURE

Identification of Ligand Analogues that Control c-di-GMP Riboswitches

(2012) Kazuhiro Furukawa et al.   ACS Chemical Biology

Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation

(2012) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase

(2012) Carly A. Shanahan et al.   BIOCHEMISTRY

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

Biofilm formation in food industries: A food safety concern

(2012) Sokunrotanak Srey et al.   FOOD CONTROL

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

(2012) Lars Plate et al.   MOLECULAR CELL

Surface sensing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production

(2012) Jennifer R. O'Connor et al.   MOLECULAR MICROBIOLOGY

Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch

(2012) Jie Zhou et al.   MOLECULES

Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover

(2012) Y. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of Wastes into Bioelectricity and Chemicals by Using Microbial Electrochemical Technologies

(2012) B. E. Logan et al.   SCIENCE

Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout

(2011) Judith Habazettl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Analogue Binding by Two Classes of c-di-GMP Riboswitches

(2011) Carly A. Shanahan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conservative Change to the Phosphate Moiety of Cyclic Diguanylic Monophosphate Remarkably Affects Its Polymorphism and Ability To Bind DGC, PDE, and PilZ Proteins

(2011) Jingxin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential binding of 2′-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins

(2011) Yiling Luo et al.   Molecular BioSystems

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

(2011) Mustafa Fazli et al.   MOLECULAR MICROBIOLOGY

Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis

(2011) Marcos V. A. S. Navarro et al.   PLOS BIOLOGY

A c-di-GMP Effector System Controls Cell Adhesion by Inside-Out Signaling and Surface Protein Cleavage

(2011) Peter D. Newell et al.   PLOS BIOLOGY

Structural and Biochemical Determinants of Ligand Binding by the c-di-GMP Riboswitch,

(2010) Kathryn D. Smith et al.   BIOCHEMISTRY

Economic impact of biofouling on a naval surface ship

(2010) M. P. Schultz et al.   BIOFOULING

Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

(2010) Shi Min Ching et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

Regulatory role of MlrA in transcription activation of csgD, the master regulator of biofilm formation in Escherichia coli

(2010) Hiroshi Ogasawara et al.   FEMS MICROBIOLOGY LETTERS

Microbial Community Analysis of Fresh and Old Microbial Biofilms on Bayon Temple Sandstone of Angkor Thom, Cambodia

(2010) Wensheng Lan et al.   MICROBIAL ECOLOGY

Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

(2010) R. P. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

An Oxygen-Sensing Diguanylate Cyclase and Phosphodiesterase Couple for c-di-GMP Control

(2009) Jason R. Tuckerman et al.   BIOCHEMISTRY

Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression

(2009) A. Duerig et al.   GENES & DEVELOPMENT

Nitric Oxide Signaling in Pseudomonas aeruginosa Biofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal

(2009) N. Barraud et al.   JOURNAL OF BACTERIOLOGY

Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms

(2009) E. Karatan et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

(2009) Thomas R. M. Barends et al.   NATURE

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Identification and Characterization of Cyclic Diguanylate Signaling Systems Controlling Rugosity in Vibrio cholerae

(2008) S. Beyhan et al.   JOURNAL OF BACTERIOLOGY

The Vibrio cholerae Hybrid Sensor Kinase VieS Contributes to Motility and Biofilm Regulation by Altering the Cyclic Diguanylate Level

(2008) H. F. Martinez-Wilson et al.   JOURNAL OF BACTERIOLOGY

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

(2008) N. Sudarsan et al.   SCIENCE