Article
Oncology
Jiwei Sun, Jingzhou Jia, Wuying Yuan, Shu Liu, Wei Wang, Lili Ge, Liyue Ge, Xiao-Jun Liu
Summary: BLACAT1 is significantly up-regulated in lung cancer tissues, acting as an oncogene; Up-regulation of BLACAT1 promotes the growth of non-small cell lung cancer cells, while knockdown of BLACAT1 reduces cell proliferation, migration and invasion; Loss of BLACAT1 significantly reduces in vivo growth and metastasis of lung cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Gustavo Alencastro Veiga Cruzeiro, Taciani de Almeida Magalhaes, Graziella Ribeiro de Sousa, Ricardo Bonfim Silva, Carlos Alberto Oliveira de Biagi Junior, Pablo Ferreira das Chagas, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera
Summary: Medulloblastoma (MB) is the most common malignant brain tumor in childhood, categorized into different molecular subgroups with the alpha subtype of the SHH subgroup considered high risk. Research has shown that YAP1 expression in SHH MB is associated with therapeutic resistance, and depletion of YAP1 may enhance responsiveness to SMO inhibitors.
Article
Oncology
Didier Frappaz, Marc Barritault, Laure Montane, Florence Laigle-Donadey, Olivier Chinot, Emilie Le Rhun, Alice Bonneville-Levard, Andreas F. Hottinger, David Meyronnet, Anne-Sophie Bidaux, Gwenaele Garin, David Perol
Summary: The study evaluated the treatment of SHH recurrent/refractory adult medulloblastoma with vismodegib + temozolomide and found no improvement in 6-month progression-free survival. Further refinements are needed for predicting sensitivity to vismodegib.
Article
Oncology
Jin Jiang
Summary: Cell-cell communication through evolutionarily conserved signaling pathways plays a crucial role in embryonic development and adult tissue homeostasis. The Hedgehog (Hh) pathway, originally discovered in Drosophila, has been found to be involved in human development and diseases. Abnormal activation of the Hh pathway is implicated in various human cancers. Studies from model organisms and human patients provide insights into the Hh signal transduction mechanisms and offer potential strategies for targeting this pathway in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Yang Dong, Wei-ming Ma, Zhen-duo Shi, Zhi-guo Zhang, Jia-he Zhou, Yang Li, Shao-qi Zhang, Kun Pang, Bi-bo Li, Wen-da Zhang, Tao Fan, Guang-yuan Zhu, Liang Xue, Rui Li, Ying Liu, Lin Hao, Cong-hui Han
Summary: Bladder urothelial carcinoma (BC) is a deadly malignancy, and Neuropilin-1 (NRP1) has been found to be highly expressed in BC tissues and cells. Knockdown of NRP1 promotes apoptosis and inhibits proliferation, angiogenesis, migration, and invasion of BC cells, potentially serving as a new therapeutic target for BC treatment. Additionally, NRP1 affects various biological functions through MAPK signaling and cancer pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Han-Jie Yang, Tian Liu, Yang Xiong
Summary: The study investigates the function of LINC00478 in bladder cancer and uncovers its inhibitory mechanism through the recruitment of histone demethylation transferase KDM1A to the MMP9 promoter region. The findings provide potential implications for novel therapeutic targets against bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Kuan-bing Chen, Wei Yang, Ying Xuan, Ai-jun Lin
Summary: This study found that miR-526b-3p can reverse cisplatin resistance in lung cancer, suppress metastasis, and activate CD8+ T cells, providing a new clue to improve the anti-tumor effects of combining immunotherapy and chemotherapy.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Wenbiao Ren, Jiao Hu, Huihuang Li, Jinbo Chen, Jian Ding, Xiongbing Zu, Benyi Fan
Summary: miR-616-5p is upregulated in bladder cancer and promotes invasion and migration; NR2C2 is a downstream target of miR-616-5p; High expression of NR2C2 correlates with better prognosis in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lisa Schneider, Junnan Liu, Cheng Zhang, Anca Azoitei, Sabine Meessen, Xi Zheng, Catharina Cremer, Christian Gorzelanny, Sybille Kempe-Gonzales, Cornelia Brunner, Felix Wezel, Christian Bolenz, Cagatay Gunes, Axel John
Summary: The study demonstrated an inverse correlation between IL1RA expression and invasive capacity and migration of bladder cancer cells, suggesting a role of IL1RA in bladder carcinogenesis. Real-time impedance sensing and porcine ex vivo organ culture methods proved to be powerful tools in discovering differences in cancer cell migration and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Mira Hamze, Igor Medina, Quentin Delmotte, Christophe Porcher
Summary: GABA plays a crucial role in the early stages of central nervous system development, with KCC2 and Shh-Smo signaling pathways impacting chloride ion balance and GABA function.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Kuang-Yu Chou, An-Chen Chang, Chao-Yen Ho, Te-Fu Tsai, Hung-En Chen, Po-Chun Chen, Thomas I-Sheng Hwang
Summary: Research on TSP4 has shown its association with the prognosis of bladder cancer, indicating that TSP4 is related to the progression and prognosis of bladder cancer, and may regulate through promoting MMP2 expression and cell motility. These findings facilitate further investigation into TSP4 silencing-based therapeutic strategies for bladder cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu, E. Du
Summary: This study found that high expression of STIL is associated with poor outcomes in bladder cancer patients. Further analysis revealed that STIL overexpression could inhibit primary cilia (PC) formation, activate SHH signaling pathways, and promote cell proliferation, while STIL knockdown could promote PC formation, inactivate SHH signaling, and inhibit cell proliferation. Furthermore, STIL was found to regulate PC through AURKA. In summary, our findings provide a potential therapy target for bladder cancer based on the restoration of PC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Chuanlai Yang, Han Xiang, Kai Fu, Lu Jin, Feng Yuan, Boxin Xue, Zhiwei Wang, Lixia Wang
Summary: Recent studies have shown that lycorine inhibits the growth and metastasis of bladder cancer cells by suppressing the expression of NEDD4. Additionally, lycorine increases the sensitivity of bladder cancer cells to gemcitabine.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
