Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Han-Jie Yang, Tian Liu, Yang Xiong
Summary: The study investigates the function of LINC00478 in bladder cancer and uncovers its inhibitory mechanism through the recruitment of histone demethylation transferase KDM1A to the MMP9 promoter region. The findings provide potential implications for novel therapeutic targets against bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Ling Zuo, Yi Zhu, Jinli Han, Hongwei Liu
Summary: This article demonstrates that circSHPRH is downregulated in bladder cancer tissues and is associated with high grade, high pathological stage, lymphatic metastasis, and poor prognosis. Silencing circSHPRH promotes proliferation, migration, and invasion of bladder cancer cells, while overexpression suppresses tumor growth. Mechanistic studies reveal that circSHPRH acts as a sponge of miR-942, targeting BARX2. Suppression of miR-942 or overexpression of BARX2 counteracts the promoting effects of circSHPRH silencing on bladder cancer cell proliferation and invasion. Additionally, circSHPRH overexpression partially eliminates the inhibitory effects of miR-942 on BARX2 expression and activates the Wnt/β-catenin signaling pathway by regulating BARX2.
Article
Oncology
Wenjie Wei, Jiayin Sun, Hui Zhang, Xingyuan Xiao, Chao Huang, Liang Wang, He Zhong, Yangkai Jiang, Xiaoping Zhang, Guosong Jiang
Summary: This study identified a novel circRNA circ0008399 that regulates the expression of target RNA through m(6)A modification by binding to WTAP, reducing cisplatin sensitivity in bladder cancer. Targeting this axis may hold potential therapeutic value.
Article
Multidisciplinary Sciences
Neveen A. A. Hussein, Shehata M. M. El Sewedy, Mohamed M. M. Zakareya, Engy A. A. Youssef, Fawziya A. R. Ibrahim
Summary: This study aimed to detect the expression status of four circRNAs (circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1) in patients with colorectal cancer (CRC) and compare them with healthy controls and non-cancer patients. The results showed that the expression of these circRNAs was significantly up-regulated in cancer patients and showed a tendency of upregulation in non-cancer patients. Furthermore, these circRNAs may have potential roles in the early detection of CRC.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ning Huang, Lei Peng, Jiaping Yang, Jinqian Li, Sheng Zhang, Mingjuan Sun
Summary: This study found that FAM111B gene is overexpressed in bladder cancer and is associated with lymphatic metastasis and reduced overall survival. Knockdown of FAM111B gene can inhibit cell proliferation and migration, induce apoptosis, and suppress tumor growth.
Article
Gastroenterology & Hepatology
Hong-Liang Zang, Fu-Jian Ji, Hai-Ying Ju, Xiao-Feng Tian
Summary: Recent research has shown that circAKT3 promotes the malignant behaviors of esophageal cancer cells by sponging miR-17-5p, indicating its potential as a therapeutic target for esophageal cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cell Biology
Shaoyi Chen, Zuxiao Chen, Zongyan Li, Shiying Li, Zilong Wen, Liangqi Cao, Yubin Chen, Ping Xue, Haiyan Li, Dawei Zhang
Summary: This study investigated the effect of exosomal circular RNAs (CircRNAs) produced by tumor-associated macrophages on the microenvironment of cholangiocarcinoma cells, and identified Circ_0020256 as a promoter of proliferation, migration, and invasion in cholangiocarcinoma cells. This promotional activity was mediated by the interaction between Circ_0020256 and its intracellular microRNA target, miR-432-5p.
CELL DEATH & DISEASE
(2022)
Article
Biophysics
Liangfen Cheng, Fuhan Yang, Yining Zhao, Ziye Liu, Xudong Yao, Juan Zhang
Summary: This study utilizes a tetrahedron supported CRISPR/Cas13a cleavage method for direct electrochemical detection of circular RNA (circRNA) in urine from bladder cancer patients. The CRISPR/Cas13a system is designed to recognize the characteristic back-splice junction site of circRNA. The activated CRISPR/Cas13a cleaves uracil bases in a DNA tetrahedron immobilized on a gold electrode, resulting in the release of an electrochemical active molecule, methylene blue. The developed electrochemical biosensor demonstrates high catalytic efficiency and a rigid structure, allowing for direct detection of circRNA in 25 μL urine samples with a lowest detection limit of 0.089 fM and a linear detection range from 10 fM to 50 nM in less than 10 minutes, avoiding the need for complicated extraction and enabling on-site detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Cell Biology
Tao Ding, Yanjun Zhu, Huimin Jin, Ping Zhang, Jianming Guo, Jianghua Zheng
Summary: circ_0057558 promotes cell proliferation and cell cycle control in prostate cancer cells by sponging miR-206 and positively regulating the transcription of miR-206 target gene USP33.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ming Wang, Ming Li, Zehan Liu, Cuinan Jiang, Hailong Lv, Qin Yang
Summary: The study aimed to investigate the role of circ_0128846 in pancreatic cancer (PC) and its interaction with miR-1270 and NR3C1. The results showed that circ_0128846 was highly expressed in PC and its deficiency inhibited cancer cell proliferation, colony formation, migration, and tumor growth. Circ_0128846 directly targeted miR-1270, which was downregulated in PC. Inhibition of miR-1270 partially reversed the suppressive effects of circ_0128846 silencing on PC progression. Furthermore, miR-1270 targeted NR3C1, and its knockdown partially abolished the repressive effects on PC cell malignant phenotypes. Our findings suggest that circ_0128846 functions as a potential biomarker and mediator in PC through the miR-1270/NR3C1 pathway.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Sajad Najafi
Summary: This review highlights the significant role of circRNAs in cervical cancer, including their regulatory functions in gene expression, impact on cell growth and apoptosis, as well as their potential for prognosis, diagnosis, and treatment in cervical cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Ji Huang, Qiu-Ming He, Qi Wu, Wei-Min Zhou, Chao Hao, Gong-Xian Wang, Xin-Hua Tu
Summary: The long non-coding RNA 00858 (LINC00858) is found to be upregulated in bladder cancer tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion of bladder cancer cells by regulating the miR-3064-5p/CTGF axis.
Article
Surgery
Juntao Zhuang, Xiao Yang, Jian Qian, Qiang Cao, Qikai Wu, Lingkai Cai, Baorui Yuan, Pengfei Shao, Jie Li, Zengjun Wang, Haiwei Yang, Pengchao Li, Qiang Lu
Summary: The study compared robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) in terms of renal function preservation and perioperative outcomes, finding no significant differences in operating time, estimated blood loss, complications, and postoperative hospital stay between the two groups. However, RAPN was superior to LPN in preserving renal function.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Review
Urology & Nephrology
Qikai Wu, Xiao Yang, Baorui Yuan, Lingkai Cai, Juntao Zhuang, Dexiang Feng, Pengchao Li, Qiang Cao, Qiang Lu
Summary: Robot-assisted laparoscopic retroperitoneal RAA repair is a flexible and safe approach with the advantage of direct access to the renal artery. In this report, a successful case of repairing a right-sided RAA via robot-assisted laparoscopic retroperitoneal approach in a 58-year-old man is presented, with no reported morbidity and improved postoperative recovery.
UROLOGIA INTERNATIONALIS
(2022)
Review
Urology & Nephrology
Baorui Yuan, Lingkai Cai, Qiang Cao, Qikai Wu, Juntao Zhuang, Xueying Sun, Yudong Zhang, Pengchao Li, Xiao Yang, Qiang Lu
Summary: This study systematically evaluated the diagnostic performance of the Vesical Imaging-Reporting and Data System in predicting muscle-invasive bladder cancer, finding different pooled sensitivity and specificity at different cut-off points. Multiple image acquisition planes of diffusion-weighted imaging should be given more attention in the system.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Oncology
Lingkai Cai, Juntao Zhuang, Qiang Cao, Baorui Yuan, Qikai Wu, Kai Li, Jie Han, Hao Yu, JianCheng Lv, Dexiang Feng, Peikun Liu, Ruixi Yu, Pengchao Li, Xiao Yang, Qiang Lu
Summary: This study demonstrates the safety and feasibility of robot-assisted surgery for the treatment of upper urinary tract tumor recurrence following radical cystectomy with cutaneous ureterostomy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiao Yang, Jiancheng Lv, Zijian Zhou, Dexiang Feng, Rui Zhou, Baorui Yuan, Qikai Wu, Hao Yu, Jie Han, Qiang Cao, Min Gu, Pengchao Li, Haiwei Yang, Qiang Lu
Summary: CTCs and CECs play a significant role in early intervention, treatment decision-making, and prognosis prediction in bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Yu, Lingkai Cai, Chunxiao Chen, Xue Fu, Liang Wang, Baorui Yuan, Xiao Yang, Qiang Lu
Summary: A novel deep learning-based model, Cascade Path Augmentation Unet (CPA-Unet), was proposed for multi-regional segmentation of the bladder, achieving superior segmentation results in terms of Dice similarity coefficient (DSC) and Hausdorff distance (HD) for inner wall, outer wall, and bladder tumor, providing a reliable foundation for computer-assisted clinical diagnosis of muscle-invasive bladder cancer.
Article
Computer Science, Software Engineering
Liang Wang, Lingkai Cai, Chunxiao Chen, Xue Fu, Jie Yu, Rongjun Ge, Baorui Yuan, Xiao Yang, Qiang Shao, Qiang Lv
Summary: This study aims to develop a new deep learning model for accurate segmentation of bladder outer wall, bladder inner wall, and bladder tumor in bladder cancer MRI. The results demonstrate that the proposed model achieves the relatively best segmentation performance on two datasets.
Article
Oncology
Jiancheng Lv, Kai Li, Hao Yu, Jie Han, Juntao Zhuang, Ruixi Yu, Yidong Cheng, Qiang Song, Kexin Bai, Qiang Cao, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: This study found that circFAM13B is downregulated in patients with bladder cancer (BCa) and is associated with lower tumor stage and better prognosis. circFAM13B promotes the function of CD8(+) T cells and inhibits glycolysis and acidic tumor microenvironment in BCa. By competitively binding to IGF2BP1 and PKM2 3'UTR, circFAM13B reduces the stability of PKM2 mRNA and inhibits glycolysis-induced acidic tumor microenvironment. This study suggests that circFAM13B can serve as a biomarker for guiding immune therapy in BCa patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Urology & Nephrology
Juntao Zhuang, Qikai Wu, Xiao Yang, Lingkai Cai, Kai Li, Hongjin Hua, Meiling Bao, Ruixi Yu, Peikun Liu, Pengchao Li, Qiang Cao, Qiang Lu
Summary: A female patient with renal tumor thrombus underwent open radical nephrectomy and thrombectomy, and showed full recovery with no recurrence after 2 years.
UROLOGIA INTERNATIONALIS
(2023)
Article
Automation & Control Systems
Zhiying Chen, Lingkai Cai, Chunxiao Chen, Xue Fu, Xiao Yang, Baorui Yuan, Qiang Lu, Huiyu Zhou
Summary: Our research aims to synthesize images from existing sequences of mp-MRI using image-to-image translation to replace missing or low signal-to-noise ratio sequences. We propose an unsupervised translation network with region-wise semantic enhancement and an improved adaptive instance normalization module. Experiments show that our approach outperforms other methods and improves the accuracy of the BCa muscular invasion classification.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lingkai Cai, Ruixi Yu, Peikun Liu, Juntao Zhuang, Kai Li, Qikai Wu, Xueying Sun, Yang Liu, Ming Zhou, Qiang Cao, Pengchao Li, Xiao Yang, Qiang Lu
Summary: This study aimed to develop a nomogram for assessing MIBC with VI-RADS 2 tumors of stalk. After analyzing and evaluating the MRI features of patients in the training and validation cohorts, tumor size, stalk width, stalk morphology, and normalized T and ST values were selected as risk factors for MIBC. The nomogram showed high performance with regards to AUC, accuracy, sensitivity, and specificity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Jiancheng Lv, Qikai Wu, Kai Li, Kexin Bai, Hao Yu, Juntao Zhuang, Huanyou Sun, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: This study identified a significant correlation between lysine N-methyltransferase SETD7 and immunotherapy sensitivity and prognosis in patients with bladder cancer. SETD7 was found to be highly expressed in bladder cancer and was associated with high histological grade and worse prognosis. Mechanistically, SETD7 promoted the proliferation, migration, and immune escape of bladder cancer cells through the upregulation of STAT3 and PD-L1.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Hao Yu, Kexin Bai, Yidong Cheng, Jiancheng Lv, Qiang Song, Haiwei Yang, Qiang Lu, Xiao Yang
Summary: ADAR is highly expressed in most cancers and is associated with the aggressiveness of some cancers, particularly bladder cancer. ADAR is also associated with immune-related genes, especially immune checkpoint genes, in the tumor immune microenvironment. Furthermore, ADAR expression is positively correlated with tumor mutation burden and microsatellite instability in various cancers, suggesting its potential as a biomarker for immunotherapy. Additionally, ADAR plays a key role in the pathogenesis of bladder cancer, promoting proliferation and metastasis of bladder cancer cells.