Mechanisms of opioid-induced respiratory depression

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression

(2021) Austin D. Hocker et al.   Frontiers in Physiology

Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity

(2021) Brian A. Baldo   ARCHIVES OF TOXICOLOGY

Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding

(2021) Jan-Marino Ramirez et al.   JOURNAL OF NEUROPHYSIOLOGY

Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker–Fuse Complex and Pre-Bötzinger Complex

(2021) Barbara Palkovic et al.   ANESTHESIOLOGY

Neural basis of opioid-induced respiratory depression and its rescue

(2021) Shijia Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

(2020) Andrea Kliewer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endogenous glutamatergic inputs to the Parabrachial Nucleus/ Kölliker-Fuse Complex determine respiratory rate

(2020) Angela A. Navarrete-Opazo et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Neurochemistry of the Kölliker‐Fuse nucleus from a respiratory perspective

(2020) Adrienn G. Varga et al.   JOURNAL OF NEUROCHEMISTRY

Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression

(2020) Sandy E. Saunders et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

KCNQs: Ligand- and Voltage-Gated Potassium Channels

(2020) Geoffrey W. Abbott   Frontiers in Physiology

Activation of μ-opioid receptors differentially affects the preBötzinger Complex and neighbouring regions of the respiratory network in the adult rabbit

(2020) Elenia Cinelli et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor

(2020) Alexander Gillis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential impact of two critical respiratory centres in opioid‐induced respiratory depression in awake mice

(2019) Adrienn G. Varga et al.   JOURNAL OF PHYSIOLOGY-LONDON

Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive

(2019) Aguan D. Wei et al.   Frontiers in Physiology

Efferent projections of excitatory and inhibitory preBötzinger Complex neurons

(2018) Cindy F. Yang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Breathing matters

(2018) Christopher A. Del Negro et al.   NATURE REVIEWS NEUROSCIENCE

Opioid receptors: drivers to addiction?

(2018) Emmanuel Darcq et al.   NATURE REVIEWS NEUROSCIENCE

Defining the Rhythmogenic Elements of Mammalian Breathing

(2018) Jan-Marino Ramirez et al.   PHYSIOLOGY

Kölliker-Fuse GABAergic and glutamatergic neurons project to distinct targets

(2017) Joel C. Geerling et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Opioid analgesic dose and the risk of misuse, overdose, and death: A narrative review

(2017) David Tyler Coyle et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

(2016) Gaspard Montandon et al.   ANESTHESIOLOGY

Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo

(2016) Yan Cui et al.   NEURON

Neonatal Abstinence Syndrome

(2016) Karen McQueen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors

(2016) Gaspard Montandon et al.   Scientific Reports

Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo

(2015) Astrid G. Stucke et al.   ANESTHESIOLOGY

Postoperative Opioid-induced Respiratory Depression

(2015) Lorri A. Lee et al.   ANESTHESIOLOGY

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive

(2015) Erica S. Levitt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Challenges for opioid receptor nomenclature: IUPHAR Review 9

(2014) Brian M Cox et al.   BRITISH JOURNAL OF PHARMACOLOGY

Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors

(2014) Srinivasan Tupal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CrossTalk proposal: The preBötzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics

(2014) Gaspard Montandon et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: The pre-Bötzinger complex is not essential for respiratory depression following systemic administration of opioid analgesics

(2014) Peter M. Lalley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice

(2013) Raphaël Weibel et al.   PLoS One

New insights into the therapeutic potential of Girk channels

(2013) Rafael Luján et al.   TRENDS IN NEUROSCIENCES

Kölliker–Fuse neurons send collateral projections to multiple hypoxia-activated and nonactivated structures in rat brainstem and spinal cord

(2012) Gang Song et al.   Brain Structure & Function

Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs

(2012) Ivana Prkic et al.   JOURNAL OF NEUROPHYSIOLOGY

PreBotzinger Complex Neurokinin-1 Receptor-Expressing Neurons Mediate Opioid-Induced Respiratory Depression

(2011) G. Montandon et al.   JOURNAL OF NEUROSCIENCE

Developmental Origin of PreBotzinger Complex Respiratory Neurons

(2010) P. A. Gray et al.   JOURNAL OF NEUROSCIENCE

Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression

(2009) Albert Dahan et al.   ANESTHESIOLOGY

Projections of preBötzinger Complex neurons in adult rats

(2009) Wenbin Tan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Clinically Relevant Infusion Rates of μ-Opioid Agonist Remifentanil Cause Bradypnea in Decerebrate Dogs but not Via Direct Effects in the pre-Bötzinger Complex Region

(2009) Sanda Mustapic et al.   JOURNAL OF NEUROPHYSIOLOGY

Neurokinin 1 Receptors Regulate Morphine-Induced Endocytosis and Desensitization of  -Opioid Receptors in CNS Neurons

(2009) Y. J. Yu et al.   JOURNAL OF NEUROSCIENCE

Opioid μ-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats

(2009) Zhenxiong Zhang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Ampakine therapy to counter fentanyl-induced respiratory depression

(2009) John J. Greer et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Opioids and the control of respiration

(2008) K.T.S. Pattinson   BRITISH JOURNAL OF ANAESTHESIA

Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat

(2008) Wenbin Tan et al.   NATURE NEUROSCIENCE