Article
Multidisciplinary Sciences
Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: Recombinant poliovirus therapy primarily mediates antitumor immunotherapy via direct infection of non-malignant tumor microenvironment cells, independent of malignant cell lysis, by inducing selective innate inflammation and sustained type-I/III interferon release, leading to polyfunctional and Th1-differentiated antitumor T cell phenotypes.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Article
Chemistry, Multidisciplinary
Qi Chen, Chaoyi Liu, Cheng Liu, Danni Zhong, Shiyuan Hua, Jian He, Kai Wang, Min Zhou
Summary: The study introduces a new approach using red blood cell membrane-coated Porphyromonas gingivalis bacteria (cmPg) to modulate the ratio of M1 and M2 macrophages in the tumor microenvironment for cancer immunotherapy. The cm coating improves bacteria's size distribution, reduces their uptake by macrophages, and sustains the polarization behavior. Additionally, the melanin in cmPg serves as a photothermal therapy agent, enabling the conversion of light to heat and facilitating photothermal-induced immunogenic cell death of cancer cells.
Review
Chemistry, Multidisciplinary
Yao Liu, Lili Niu, Nannan Li, Yang Wang, Mingyang Liu, Xiaomin Su, Xuhui Bao, Bo Yin, Shun Shen
Summary: Bacteria-mediated antitumor therapy holds promise for overcoming physiological barriers and tumor immunosuppression, improving treatment efficacy, reducing side effects, and combating drug resistance. Bacteria have the ability to destroy tumor cells from within and induce innate and adaptive antitumor immune responses. Moreover, bacterial components can be reprogrammed to produce and deliver antitumor agents according to clinical needs.
Article
Nanoscience & Nanotechnology
Jiabao Ling, Yanzhou Chang, Zhongwen Yuan, Qi Chen, Lizhen He, Tianfeng Chen
Summary: This study proposes a feasible therapeutic strategy for depleting lactate and reconstructing an immunosuppressive tumor microenvironment using Se-containing nanosheets, which can restore the potent tumor-killing activity of macrophages, thereby amplifying the effects of TAM-based antitumor immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Guanghong Luo, Xing Li, Jihui Lin, Gao Ge, Jiangli Fang, Wangze Song, Gary Guishan Xiao, Bo Zhang, Xiaojun Peng, Yanhong Duo, Ben Zhong Tang
Summary: Ions play a vital role in regulating various biological processes, including tumorigenesis and therapy. The perturbation of ion homeostasis can induce tumor cell death and evoke immune responses. This study prepared a pH-responsive nanoplatform that reprograms the tumor microenvironment and provides antitumor treatment through ion fluctuation.
Review
Immunology
Bo Wang, Yue Zhang, Xunzhe Yin
Summary: Immunotherapy is a promising treatment for cancer, but its clinical application is limited by the lack of precision in targeting lesions and the occurrence of adverse reactions. Nanodrug delivery systems provide a solution by enabling precise drug delivery and enhancing the immune response while reducing adverse reactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sagang Koo, Ok Kyu Park, Jonghoon Kim, Sang Ihn Han, Tae Yong Yoo, Nohyun Lee, Young Geon Kim, Hyunjoong Kim, Chaehong Lim, Jong-Seong Bae, Jin Yoo, Dokyoon Kim, Seung Hong Choi, Taeghwan Hyeon
Summary: The study presents a heterogeneous chemodynamic therapy (CDT) system based on copper-iron peroxide nanoparticles for synergistic therapy in the tumor microenvironment (TME). The system demonstrates excellent tumor therapeutic efficacy by enhancing hydroxyl radical production through a highly efficient catalytic loop. It also generates O-2 and exhibits TME-responsive T-1 magnetic resonance imaging contrast enhancement.
Review
Pharmacology & Pharmacy
Qin Xie, Jian Ding, Yi Chen
Summary: CD8(+) T lymphocytes play a crucial role in host antitumor immunity, but tumor-driven microenvironments can inhibit their activation and cytotoxicity. Stromal cells exert immunosuppressive effects in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Dipti Thakkar, Shalini Paliwal, Bhushan Dharmadhikari, Siyu Guan, Lillian Liu, Shreya Kar, Nikhil K. Tulsian, Joshua J. Gruber, Leah DiMascio, Konrad H. Paszkiewicz, Piers J. Ingram, Jerome D. Boyd-Kirkup
Summary: This study developed the first Fc-independent anti-VISTA antibody HMBD-002, which reverses VISTA-induced immune suppression by blocking the functional domain of VISTA. The antibody has a neutralizing, non-depleting effect, effectively inhibiting tumor growth and enhancing T cell activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ziena Abdulrahman, Saskia J. Santegoets, Gregor Sturm, Pornpimol Charoentong, Marieke E. Ijsselsteijn, Antonios Somarakis, Thomas Hollt, Francesca Finotello, Zlatko Trajanoski, Sylvia L. van Egmond, Dana A. M. Mustafa, Marij J. P. Welters, Noel F. C. C. de Miranda, Sjoerd H. van der Burg
Summary: This study investigates the tumor immune microenvironment associated with tumor-specific T-cell responses and finds that IR+ patients have higher survival rates and immune cell infiltration, while IR- patients exhibit the presence of immunosuppressive cells. Tumor-specific T cells in IR+ tumors produce chemokines to sustain immune cell aggregation, which is associated with good survival after standard therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chen Zhao, Ronald N. Germain
Summary: Multiplex imaging is a valuable tool for studying the interactions among immune cells, stroma, and malignant cells within the tumor microenvironment. It holds significant promise for discovering biomarkers and therapeutic targets. However, challenges exist in study design, experiment optimization, and data analysis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Rui Tang, Hongye He, Xiaohong Lin, Nianhong Wu, Li Wan, Qiaoqi Chen, Yaqin Hu, Chen Cheng, Yuting Cao, Xun Guo, Ying Zhou, Xialin Xiong, Min Zheng, Qi Wang, Faqi Li, Yang Zhou, Pan Li
Summary: Combining high-intensity focused ultrasound (HIFU) with immunomodulation can effectively treat solid tumors and stimulate anti-tumor immune response to inhibit tumor recurrence and metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen, Chunyu Xu, Arash Saeedi, Ke Pan, Ritu Bohat, Nicholas A. Egan, Jodi A. McKenzie, Rina M. Mbofung, Leila J. Williams, Zhenhuang Yang, Ming Sun, Xiaofang Liang, Jordi Rodon Ahnert, Navin Varadarajan, Cassian Yee, Yiwen Chen, Patrick Hwu, Weiyi Peng
Summary: This study used genome-wide CRISPR immune screens to identify immunosuppressive mechanisms in non-responders to cancer immunotherapy and integrated the results with multi-omics clinical data to evaluate the role of tumor intrinsic factors in regulating two key steps of cancer immunotherapy. Two distinct types of immune resistance regulators were revealed, with PRMT1 and RIPK1 identified as potential therapeutic targets to improve the efficacy of immunotherapy. Targeting PRMT1 and RIPK1 sensitized tumors to T-cell killing and anti-PD-1/OX40 treatment, providing novel targets for rational immuno-oncology combinations.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Shakoora A. Sabree, Andrew P. Voigt, Sue E. Blackwell, Ajaykumar Vishwakarma, Michael S. Chimenti, Aliasger K. Salem, George J. Weiner
Summary: The study found that anti-Q beta-coated CMP-001 induces IFN-alpha production by pDCs, which has secondary effects on monocytes and enhances their response to IFN-alpha, promoting autologous CD4 T-cell proliferation. Despite exhibiting aspects of an immunosuppressive phenotype, these monocytes show increased ability to augment T-cell proliferation, shedding light on the complex mechanism of action of anti-Q beta-coated CMP-001 and providing insights into pathways to enhance the efficacy of this novel immunotherapy approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Juanjuan Li, Zhenzhen Fu, Yong Liu
Summary: Liquid metal nanoparticles functionalized with surfactant molecules are used to assemble a nanocomposite material with a liquid metal core and a zeolitic-imidazolate framework shell. The resulting supraparticles are incorporated into an alginate-based hydrogel, which displays physiologically responsive sol-gel transformation, stable photothermal performance, and controllable zinc ion release. The composite hydrogel serves as a dual functional antitumor and antibacterial biomedicine, completely eradicating tumor cells/bacteria after a single treatment with laser-activated composite hydrogel.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Haiyan Guo, Zhenping Cao, Juanjuan Li, Zhenzhen Fu, Sisi Lin, Lu Wang, Jinyao Liu
Summary: Photosensitizer-based therapy faces limitations such as weak and easily attenuated photosensitive effects, poor tumor penetration and retention, and the need for multiple irradiation. In this study, bacteria were engineered to express melanin and coated with synthetic photosensitizers, forming a ternary combination for photoacoustic imaging-guided photothermal therapy. The integrated bacteria exhibited stable triple photoacoustic and photothermal effects under monochromatic irradiation, and were able to preferentially colonize hypoxic tumor tissue and generate uniform imaging signals and sufficient heating upon laser irradiation. The results showed inhibited tumor growth and extended survival in different tumor-bearing mouse models, suggesting the potential of bacteria-based innovative photosensitizers for imaging-guided therapy.
Article
Chemistry, Medicinal
Yunxiang Yan, Ye Li, Hong Li, Xiang Ma, Yanqiong Tang, Kexian Yi, Xiangmin Lin, Juanjuan Li, Zhu Liu
Summary: Researchers synthesized a drug-loaded metal-organic framework (ZIF-8@PT) to improve the sensitivity of bacteria to the drug and enhance its intracellular delivery by destroying bacterial biofilms and cell membranes. ZIF-8@PT effectively suppressed abdominal infections induced by multidrug-resistant Aeromonas veronii C4 in rodent models without systemic toxicity.
ACS INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Guocheng Xie, Sisi Lin, Feng Wu, Jinyao Liu
Summary: The low bioavailability and side effects of conventional drugs for eye disease have led to the development of efficient drug delivery systems using nanomaterials. This review highlights the unique functions of nanomaterials for carrying and transporting ocular drugs, as well as various strategies to enhance their performance. The current applications and limitations of nanomaterial-based delivery systems in treating ocular diseases are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Chao Pan, Lu Wang, Mengmeng Zhang, Juanjuan Li, Junqiu Liu, Jinyao Liu
Summary: Introduces a new immunization strategy called in situ polymerization-mediated antigen presentation (IPAP), which allows antigen-loaded nanovaccines to spontaneously form and efficiently anchor onto dendritic cells in vivo through co-deposition with dopamine. IPAP promotes antigen presentation by increasing cell uptake and reducing antigen degradation. It prolongs antigen duration and enhances accumulation in lymph nodes, resulting in strong antigen-specific immune responses. IPAP is applicable for different antigens and overcomes the disadvantages of complex preparation and purification processes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Yong Liu, Fei Yang, Zixin Pan, Zhenzhen Fu, Xiaoli Jiang, Zhenping Cao, Juanjuan Li, Hao Wang
Summary: Metallic materials have long been used as antibacterial agents, and gallium, an abiogenic metal, has shown pharmaceutical effects in developing unconventional anticancer and antibacterial drugs. Recent research has demonstrated the potential of gallium-based materials in creating safe, efficacious, multifunctional, and even smart bactericidal medicine. This study provides a comprehensive guide for the design, fabrication, and implementation of gallium-based materials.
Article
Oncology
Yutong Cui, Jiani Han, Hong Li, Xiang Ma, Yanqiong Tang, Yong Deng, Dayong Wang, Denggao Huang, Juanjuan Li, Zhu Liu
Summary: In this study, we fabricated fluorescence gold nanoclusters decorated gas vesicles for ultrasound-mediated enhanced cellular delivery and imaging. The gas vesicles showed improved stability and fluorescence ability compared to free gold nanoclusters. The flow cytometry assay and confocal images confirmed the enhanced cellular uptake and imaging efficiency of the gas vesicles under ultrasound impact.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Biomedical
Yunxiang Yan, Yong Liu, Juanjuan Li, Ye Li, Haoheng Wu, Hong Li, Xiang Ma, Yanqiong Tang, Yuan Tong, Kexian Yi, Quanfeng Liang, Zhu Liu
Summary: A molecular switch-integrated, photo-responsive nanoplatform based on hollow mesoporous silica nanospheres (HMSN) loaded with silver nanoparticles (Ag NPs), vancomycin (Van), and hemin (HAVH) is reported for bacteria elimination and abscess therapy. The molecular switch hemin can be released from HMSN upon near-infrared (NIR) light irradiation, triggering the release of pre-loaded Ag+ and Van, enabling photothermal-modulated drug release and synergistic photothermal-chemo therapy (PTT-CHT). This study presents a new strategy for antibacterial drug delivery with high controllability and extendibility, which may benefit the development of smart multifunctional nanomedicine for diseases not limited to bacterial infections.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiao Kuang, Ying Liu, Huilong Luo, Qian Li, Feng Wu, Chunhai Fan, Jinyao Liu
Summary: A triggerable prodrug nanocoating is reported for combination treatment, addressing the limitations of current combination strategies. The nanocoating enables the on-demand activation of living microbial and small-molecular therapeutics, leading to enhanced treatment efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Hejin Jiang, Zhenping Cao, Ying Liu, Rui Liu, Yan Zhou, Jinyao Liu
Summary: This review discusses the strategies for preparing bacteria-based living probes, including biological engineering, chemical modification, intracellular loading, and optical manipulation. It summarizes the recent progress of these probes in different imaging modalities and highlights their applications in bioimaging and diagnosis of bacterial infections, cancers, and intestine-associated diseases. The advantages, challenges, and future perspectives of bacteria-based living probes are also discussed.
Article
Chemistry, Multidisciplinary
Fangjie Chen, Mengmeng Zhang, Fengmin Yang, Lu Wang, Jinyao Liu, Junqiu Liu, Yan Pang
Summary: This study presents the development of dual-antigen-displaying nanovaccines to treat cancer and prevent infection. The nanovaccines are shown to reverse immune suppression and delay tumor growth while inducing protective immune responses.
Review
Chemistry, Multidisciplinary
Sisi Lin, Feng Wu, Yifan Zhang, Huan Chen, Haiyan Guo, Yanmei Chen, Jinyao Liu
Summary: The past decade has seen significant progress in bacteria-based living agents, with their unique characteristics enabling genetic manipulation, rapid proliferation, colonization, and disease site targeting. However, translating these agents to clinical applications remains challenging due to environmental susceptibility, toxic side effects, and limited accumulation at target sites. Surface modification of bacteria offers a solution by chemically altering components and introducing new functions. This review examines the synthesis, functionalization, and biomedical applications of surface-modified bacteria, highlighting the advantages, limitations, and future challenges in utilizing these agents for bioimaging, diagnosis, and therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Sisi Lin, Feng Wu, Yifan Zhang, Huan Chen, Haiyan Guo, Yanmei Chen, Jinyao Liu
Summary: This article reviews the strategies for surface chemical modification of bacteria and the advanced functions achieved by modifying specific surface components, highlighting the applications of modified bacteria for bioimaging, diagnosis, and therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
