Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides

How Do Biomolecules Cross the Cell Membrane?

(2022) Dehua Pei   ACCOUNTS OF CHEMICAL RESEARCH

Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells

(2021) Grégoire J.-B. Philippe et al.   ACS Chemical Biology

Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins

(2021) Sonia Khemaissa et al.   Crystals

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

(2020) Benjamin M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells

(2020) Daniel Y. Yoo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding Cell Penetration of Cyclic Peptides

(2019) Patrick G. Dougherty et al.   CHEMICAL REVIEWS

Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides

(2018) Koki Sakagami et al.   MOLECULAR PHARMACEUTICS

Tuning the binding affinity and selectivity of perfluoroaryl-stapled peptides by cysteine-editing

(2018) Sanne J. M. Verhoork et al.   CHEMISTRY-A EUROPEAN JOURNAL

Arylation Chemistry for Bioconjugation

(2018) Bradley Pentelute et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

(2017) Daniela Kalafatovic et al.   MOLECULES

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

(2017) Anthony J. Rojas et al.   Chemical Science

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

(2016) Ziqing Qian et al.   BIOCHEMISTRY

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

(2016) Grégoire Philippe et al.   BIOPOLYMERS

Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol SNAr chemistry

(2016) Elaine A. Qian et al.   Nature Chemistry

A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects

(2016) Xavier Lucas et al.   Chemical Science

Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes

(2016) Bingdi Chen et al.   Theranostics

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

(2016) Peter Lönn et al.   Scientific Reports

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Anion−π Interactions with Fluoroarenes

(2015) Michael Giese et al.   CHEMICAL REVIEWS

π-Clamp-mediated cysteine conjugation

(2015) Chi Zhang et al.   Nature Chemistry

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of tryptophan side chains in membrane protein anchoring and hydrophobic mismatch

(2012) Armando J. de Jesus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

Protein Transduction Domain Mimics: The Role of Aromatic Functionality

(2011) Abhigyan Som et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Free-energy relationships for the interactions of tryptophan with phosphocholines

(2009) Georg Blaser et al.   ORGANIC & BIOMOLECULAR CHEMISTRY