Journal
ANALYTICAL CHEMISTRY
Volume 94, Issue 20, Pages 7174-7180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c05086
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Funding
- National Natural Science Foundation of China [22076190, 21876176, 21777163, 21705152, 62171433]
- Youth Innovation Promotion Association, CAS, China [2019432]
- Anhui Provincial Key RD Program [202104d07020003]
- HFIPS Director's Fund [BJPY2021B08, YZJJ2022QN45]
- Second Affiliated Hospital of Anhui Medical University
- Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences [LHJJ2020006]
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A novel DC-ion funnel drift tube has been developed for proton transfer reaction mass spectrometry (PTR-MS), which exhibits higher sensitivity compared to traditional drift tubes. The DC-ion funnel drift tube achieves ion focusing using only a DC electric field and is suitable for miniaturization and low power consumption.
We have developed and characterized a novel drift tube called the direct current-ion funnel (DC-ion funnel) drift tube, consisting of 20 traditional ring electrodes and 5 new DC-focusing electrodes (DC-FEs) for use in proton transfer reaction mass spectrometry (PTR-MS). Ion trajectory simulations demonstrate the ion focusing effect of the DC-FE and DC-ion funnel drift tube. Further comparative experiments show that the PTR-MS with the novel DC-ion funnel drift tube has a higher sensitivity (3.8-7.3 times for the volatile organic compounds considered in this work) than the PTR-MS with a traditional drift tube. Different from conventional radiofrequency (rf) focusing methods, the DC-ion funnel drift tube can realize ion focusing with only a DC electric field and no additional rf power supply, which makes it especially suitable for instruments requiring miniaturization and low power consumption to improve detection sensitivity. In addition, the DC-ion funnel drift tube can easily be coupled to other types of mass spectrometers to increase their detection sensitivity.
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