Coupling Lipid Nanoparticle Structure and Automated Single‐Particle Composition Analysis to Design Phospholipase‐Responsive Nanocarriers

I22: SAXS/WAXS beamline at Diamond Light Source – an overview of 10 years operation

(2021) A. J. Smith et al.   JOURNAL OF SYNCHROTRON RADIATION

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

(2021) Jeremy P. Bost et al.   ACS Nano

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

Breaking Isolation to Form New Networks: pH-Triggered Changes in Connectivity inside Lipid Nanoparticles

(2021) Zexi Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds

(2020) Reika Tei et al.   JOURNAL OF CELL BIOLOGY

Illustrating human PLD

(2020) Lei Zheng et al.   Nature Chemical Biology

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

(2020) Christian D. Siewert et al.   Cells

Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine

(2019) Jiali Zhai et al.   ACS Nano

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

pH Responsiveness of Hexosomes and Cubosomes for Combined Delivery of Brucea javanica Oil and Doxorubicin

(2019) Yawen Li et al.   LANGMUIR

Engineering Swollen Cubosomes Using Cholesterol and Anionic Lipids

(2019) Hanna M. G. Barriga et al.   LANGMUIR

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Mammalian phospholipase D: Function, and therapeutics

(2019) M.I. McDermott et al.   PROGRESS IN LIPID RESEARCH

Cubosomes; the next generation of smart lipid nanoparticles?

(2018) Hanna Maria Gabriella Barriga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains

(2018) Alexandru Zabara et al.   Nature Communications

Microfluidics Synthesis of Gene Silencing Cubosomes

(2018) Hojun Kim et al.   ACS Nano

Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement

(2018) Margaret N. Holme et al.   ACS Central Science

Single Particle Automated Raman Trapping Analysis

(2018) Jelle Penders et al.   Nature Communications

Targeting phospholipase D in cancer, infection and neurodegenerative disorders

(2017) H. Alex Brown et al.   NATURE REVIEWS DRUG DISCOVERY

Lipidic Cubic-Phase Nanoparticles-Cubosomes for Efficient Drug Delivery to Cancer Cells

(2017) Ewa Nazaruk et al.   ChemPlusChem

Effects of High Pressure on Internally Self-Assembled Lipid Nanoparticles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

(2016) Chandrashekhar V. Kulkarni et al.   LANGMUIR

Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

(2016) E. Nicholas Petersen et al.   Nature Communications

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Electrostatic swelling of bicontinuous cubic lipid phases

(2015) Arwen I. I. Tyler et al.   Soft Matter

Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography

(2015) Davide Demurtas et al.   Nature Communications

Multicompartment Lipid Cubic Nanoparticles with High Protein Upload: Millisecond Dynamics of Formation

(2014) Borislav Angelov et al.   ACS Nano

Monitoring Phosphatidic Acid Formation in Intact Phosphatidylcholine Bilayers upon Phospholipase D Catalysis

(2014) Chunming Liu et al.   ANALYTICAL CHEMISTRY

Controlling enzymatic activity and kinetics in swollen mesophases by physical nano-confinement

(2014) Wenjie Sun et al.   Nanoscale

Mantid—Data analysis and visualization package for neutron scattering andμSR experiments

(2014) O. Arnold et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous monitoring of phospholipid vesicle hydrolysis by phospholipase D (PLD) reveals differences in hydrolysis by PLDs from 2 Streptomyces species

(2012) Satomi Hirano et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Phospholipase D: Enzymology, Functionality, and Chemical Modulation

(2011) Paige E. Selvy et al.   CHEMICAL REVIEWS

Applications of neutron and X-ray scattering to the study of biologically relevant model membranes

(2010) G. Pabst et al.   CHEMISTRY AND PHYSICS OF LIPIDS