A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats

(2021) Jie Sun et al.   ACS Biomaterials-Science & Engineering

Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity

(2021) Songwei Yang et al.   Journal of Inflammation Research

Positioning therapies in ulcerative colitis

(2020) Silvio Danese et al.   Clinical Gastroenterology and Hepatology

Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation

(2020) Shuai Zhao et al.   Mucosal Immunology

A di-self-crosslinking hyaluronan-based hydrogel combined with type I collagen to construct a biomimetic injectable cartilage-filling scaffold

(2020) Ya Yao et al.   Acta Biomaterialia

The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

(2020) Yang Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer

(2019) Yu-Wen Lo et al.   Acta Biomaterialia

ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance

(2019) Li Lin et al.   Cell Death & Disease

Colonic epithelial cell diversity in health and inflammatory bowel disease

(2019) Kaushal Parikh et al.   NATURE

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

(2019) Christina Leichner et al.   ADVANCED DRUG DELIVERY REVIEWS

Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation

(2019) Ying-Zheng Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways

(2019) Nesrine S. El Sayed et al.   ARCHIVES OF TOXICOLOGY

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

(2019) Yonghyun Lee et al.   NATURE MATERIALS

Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice

(2019) Ziwen Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease

(2019) Xin Cong et al.   CELLULAR SIGNALLING

Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease

(2018) Joannie M. Allaire et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Goblet cells: multifaceted players in immunity at mucosal surfaces

(2018) Kathryn A. Knoop et al.   Mucosal Immunology

Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus

(2018) Dayong Ren et al.   BMC MICROBIOLOGY

Thiolated polymers as mucoadhesive drug delivery systems

(2017) Sarah Duggan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The safety of non-biological treatments in Ulcerative Colitis

(2017) Edoardo Troncone et al.   Expert Opinion On Drug Safety

Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

(2017) Jeff Chang et al.   GASTROENTEROLOGY

Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice

(2017) Vanessa Popp et al.   GASTROENTEROLOGY

Characteristics of Faecal Microbiota in Paediatric Crohn’s Disease and Their Dynamic Changes During Infliximab Therapy

(2017) Yizhong Wang et al.   Journal of Crohns & Colitis

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second-Degree Scald

(2017) He-Lin Xu et al.   Advanced Healthcare Materials

Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine

(2017) Haihui Zheng et al.   Frontiers in Microbiology

Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels

(2016) Nicole J. Darling et al.   BIOMATERIALS

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

(2016) Michael K. Lichtman et al.   WOUND REPAIR AND REGENERATION

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

(2015) Sufeng Zhang et al.   Science Translational Medicine

Tight junction disruption:Helicobacter pyloriand dysregulation of the gastric mucosal barrier

(2015) Tyler J Caron   WORLD JOURNAL OF GASTROENTEROLOGY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Mind the GAPs: insights into intestinal epithelial barrier maintenance and luminal antigen delivery

(2014) M J Miller et al.   Mucosal Immunology

Dually degradable click hydrogels for controlled degradation and protein release

(2014) Prathamesh M. Kharkar et al.   Journal of Materials Chemistry B

Diels–Alder Mediated Controlled Release from a Poly(ethylene glycol) Based Hydrogel

(2013) Kenneth Christopher Koehler et al.   BIOMACROMOLECULES

Multifunctional biohybrid hydrogels for cell culture and controlled drug release

(2013) Huaimin Wang et al.   CHEMICAL COMMUNICATIONS

The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry

(2013) Devatha P. Nair et al.   CHEMISTRY OF MATERIALS

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Dextran and gelatin based photocrosslinkable tissue adhesive

(2012) Tao Wang et al.   CARBOHYDRATE POLYMERS

Reversible maleimide–thiol adducts yield glutathione-sensitive poly(ethylene glycol)–heparin hydrogels

(2012) Aaron D. Baldwin et al.   Polymer Chemistry

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

In situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition

(2011) Yao Fu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

(2009) Hamed Laroui et al.   GASTROENTEROLOGY

Defensins and inflammation: The role of defensins in inflammatory bowel disease

(2009) Malith Ramasundara et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Transferrin as a Luminal Target for Negatively Charged Liposomes in the Inflamed Colonic Mucosa

(2009) Boaz Tirosh et al.   MOLECULAR PHARMACEUTICS

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

(2007) Klaus Kannengiesser et al.   INFLAMMATORY BOWEL DISEASES