Article
Engineering, Biomedical
Jinsheng Huang, Zecong Xiao, Yongcheng An, Shisong Han, Wei Wu, Yong Wang, Yu Guo, Xintao Shuai
Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.
Article
Oncology
Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi, Rossana Signorelli, Harrys K. C. Jacob, John George, Preeti Sahay, Ejas P. Bava, Rajinder Dawra, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja
Summary: The absence of Hsp70 in the tumor microenvironment inhibits tumor growth through immune cells, and Hsp70(-/-) dendritic cells inhibit tumor growth by enhancing the immune response.
Article
Engineering, Biomedical
Shengxin Huang, Dongbing Ding, Tianyun Lan, Guanhui He, Jiannan Ren, Rongpu Liang, Huihai Zhong, Gengjia Chen, Xue Lu, Xintao Shuai, Bo Wei
Summary: A nanodrug was prepared to convert cold tumors into hot tumors, improving the efficacy of immune checkpoint blockade therapy in colorectal cancer.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Environmental
Xiaoyan Qu, Zhengqing Liu, Na Li, Bohan Ma, Hongyang Zhao, Ying Li, Bo Lei, Yaping Du
Summary: This study presents the application of biodegradable porous magnesium oxide nanoparticles with acid-base conversion ability in cancer therapy. These nanoparticles can rapidly convert to alkaline nanosheets under the acidic tumor microenvironment, allowing efficient uptake by cancer cells and suppression of tumor growth. This is the first example of responsive cancer therapy based on biodegradable single inorganic nanomaterials through chemical structure conversion mechanism.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Jianqin Yan, Xuehua Long, Yan Liang, Fashun Li, Hongli Yu, Yifei Li, Zhipeng Li, Yu Tian, Bin He, Yong Sun
Summary: This paper reviews the applications of nanodrug delivery systems (NDDS) in the treatment of cancer stem cells (CSCs). Nanocarriers have advantages such as small size and good biocompatibility, and can achieve targeted drug delivery, making them important for eliminating CSCs. The challenges and future research directions of NDDS for CSCs therapy are also discussed in this paper.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Poonam R. Pandey, Ken H. Young, Dhiraj Kumar, Neeraj Jain
Summary: The tumor immune microenvironment (TIME) plays a crucial role in tumor growth and metastasis by influencing the balance of immune-suppressive and cytotoxic responses. RNA-based therapeutics targeting RNA regulators in the TIME show promise in cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Bozhao Li, Xiuping Zhang, Zhouliang Wu, Tianjiao Chu, Zhenlin Yang, Shuai Xu, Suying Wu, Yunkai Qie, Zefang Lu, Feilong Qi, Minggen Hu, Guodong Zhao, Jingyan Wei, Yuliang Zhao, Guangjun Nie, Huan Meng, Rong Liu, Suping Li
Summary: A wound-targeted nanodrug has been developed to decrease the risk of relapse after hepatocellular carcinoma (HCC) surgery, leading to improved 5-year survival rate. This nanodrug combines an immune checkpoint inhibitor and an angiogenesis inhibitor to effectively target the surgical margin and inhibit HCC relapse. Animal studies have shown promising results in terms of anti-tumor effects and overall survival.
Article
Chemistry, Multidisciplinary
Ming Gong, Yufeng Huang, Huixiong Feng, Jiaming Lin, Anfei Huang, Jinxin Hu, Qinglian Tang, Xiaojun Zhu, Shisong Han, Jinchang Lu, Jin Wang
Summary: In this study, a biomimetic nanodrug named MPIRx was developed, which showed significant inhibition of osteosarcoma proliferation and migration, induction of apoptosis and immunogenic cell death. In addition, MPIRx guided macrophage migration towards tumor cells, promoted M1-type polarization, and increased macrophage phagocytosis activity on osteosarcoma cells. Furthermore, MPIRx successfully inhibited subcutaneous and orthotopic tumors, as well as the development of pulmonary metastasis. Overall, MPIRx presents a novel strategy for macrophage-related immunotherapy to eliminate osteosarcoma and inhibit intractable pulmonary metastasis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Immunology
Aleksandra J. Ozga, Melvyn T. Chow, Andrew D. Luster
Summary: Chemokines play a critical role in directing immune cell migration and are involved in shaping the tumor-promoting microenvironment.
Article
Engineering, Biomedical
Guang-Yu Lian, Yingpeng Wan, Thomas Shiu-Kwong Mak, Qing-Ming Wang, Jinfeng Zhang, Jiaoyi Chen, Zi-Ying Wang, Min Li, Patrick Ming-Kuen Tang, Xiao-Ru Huang, Chung-Sing Lee, Xue-Qing Yu, Hui-Yao Lan
Summary: This study developed a novel therapeutic strategy for lung carcinoma by developing a specific inhibitor of Smad3 (SIS3) into a self-carried nanodrug (SCND-SIS3). SCND-SIS3 demonstrated better anti-cancer effects in an animal model and achieved comparable efficacy with just one-fifth of the dose of unmodified-SIS3.
Review
Multidisciplinary Sciences
Lei Lei, Dennis Huang, Huile Gao, Bin He, Jun Cao, Nicholas A. Peppas
Summary: This review introduces the advantages of using hydrogels in cancer vaccine delivery systems, including their ability to encapsulate antigens and protect them from degradation, reverse immunosuppression and stimulate immune response, as well as their precise drug release capability.
Article
Cell Biology
Xiangzheng Liu, Xueqian Shang, Jian Li, Shijie Zhang
Summary: The study found that B cells and DC1 could predict the prognosis and immune checkpoint blockade efficacy of LUAD and LUSC patients respectively. Tissues with high infiltration of B cells and DC1 may benefit more from ICB therapy, and certain genes and KEGG pathways may serve as novel immunotherapy targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chunchen Xu, Xiaoyuan Ji, Yanfeng Zhou, Yuchun Cheng, Daoxia Guo, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: A study introduces a novel approach to revitalize tumor-associated dendritic cells (TADCs) and enhance their anti-tumor response. This is achieved by using multilevel lipid rewiring nanoparticles to promote TADC maturation and restore their inflammatory cytokine production, cytotoxic T cell recruitment, and tumor inhibition.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Sara Nava, Daniela Lisini, Simona Frigerio, Anna Bersano
Summary: DCs vaccines have established safety and the ability to induce anti-tumor responses, and combining with other treatments may improve efficacy. Combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy could be the key to cancer treatment paradigms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Statistics & Probability
Jiyanglin Li, Tao Li
Summary: This article studies the time-varying additive model with time-varying autoregression error in the locally stationary context and proposes a two-step estimation for it. The B-spline method is used to obtain the initial estimator of trend function and additive components, and ULASSO is used to estimate the structure of autoregression error. The improved estimator of trend function and additive components is derived using local linear smoothing. Simulation studies and a real data application demonstrate the effectiveness and applicability of the proposed model.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2023)
Article
Engineering, Chemical
Weixiang Zhang, Yongbin Liu, Qingpeng Zhao, Dawei Liu, Xiaoxun Ma, Long Xu
Summary: In this study, a series of zirconium-doped cerium-based composite oxygen carriers were prepared using the ball milling method. The addition of carbon nanotubes was found to greatly increase the specific surface area and activity of the oxygen carriers. The kinetics of H2 reduction of the oxygen carriers were best described by a three-dimensional diffusion model. Additionally, the activation energies of the oxygen carriers corresponded with their reactivity sequence.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Clinical Neurology
Jia Wang, Xing Xiong, Jinzhao Zou, Jianxiong Fu, Yili Yin, Jing Ye
Summary: Based on CT scans of patients with acute intracerebral hemorrhage (ICH), we developed a nomogram model and a support vector regression (SVR) model to predict perihematomal edema (PHE) volumes. These models showed good performance in distinguishing different PHE volumes and were consistent with the actual outcomes.
CLINICAL NEURORADIOLOGY
(2023)
Article
Andrology
Hui Ji, Shanren Cao, Hui Ding, Li Dong, Chun Zhao, Junqiang Zhang, Jing Lu, Xiuling Li, Xiufeng Ling
Summary: This study aimed to evaluate the impact of post-thaw culture duration on the clinical outcomes of frozen blastocyst transfer. The results showed no statistical differences in the main outcomes among the groups following D5 blastocyst transfer. However, patients in the long culture group following D6 blastocyst transfer had significantly lower implantation, clinical pregnancy, and live birth rates, but a higher abortion rate compared to those in the short culture group. No superiority was found among the different short culture durations for D6 blastocyst vitrification in terms of live birth outcomes.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhaoyang Cheng, Minghua Li, Xu-Yang Zhang, Yue Sun, Qing-Lei Yu, Xing-Hong Zhang, Zhan Lu
Summary: A cobalt-catalyzed regiodivergent double hydrosilylation reaction has been developed, enabling the synthesis of bis(silane)s with specific regioselectivity. These bis(silane)s show promising applications in optical materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Thermodynamics
Fei Xu, Ling Hao, Lei Chen, Qun Chen, Mingshan Wei, Yong Min
Summary: This paper proposes a new method of improving wind power accommodation by integrating district heating networks flow rate regulation into power dispatch. The results show that wind power accommodation increases with increasing flow rate due to increased thermal inertia. However, the flow rate cannot be too high as the electricity consumption of water pumps becomes the main reason for improving wind power accommodation.
Article
Chemistry, Physical
Xiaoyi Xue, Chuanming Ma, Yanrong Liu, Hao Wang, Qingjun Chen
Summary: Vanadium-based alloys are promising materials for hydrogen storage due to their high capacity at ambient conditions. However, the challenges of complex activation and poor stability at high temperatures limit their large-scale applications. In this study, TiCr3V16Cex (x = 0, 0.1, 0.2, 0.4, 1) hydrogen storage alloys with different Ce contents were developed and investigated for their hydrogen storage performance, activation mechanism, and absorption mechanism. The results showed that Ce doping increased the plateau pressure while slightly decreasing the hydrogen storage capacity. Ce doping also affected the kinetics and thermodynamics of the alloy. The TiCr3V16Cex (x = 0.2, 0.4, 1) alloys exhibited hydrogen absorption and desorption at room temperature without activation. The optimum alloy, TiCr3V16Ce0.2, showed a high hydrogen absorption rate and effective hydrogen desorption capacity. After cycling, the alloy maintained its original capacity. The Ce-doped BCC alloy developed in this study offers a new route for achieving high hydrogen storage performance under mild conditions.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Applied
Xinyu Wang, Xiaoyan Liu, Naiwen Shi, Zhuanyuan Zhang, Yiming Chen, Mingyan Yan, Yinping Li
Summary: In this study, the maximum extracted efficiency of okra polyphenols was determined using response surface methodology, and 27 compounds were identified in okra polyphenols using HPLC-ESI-QTOF-MS/MS. Additionally, okra polyphenols exhibited strong antioxidant activity and alleviated oxidative damage.
Article
Chemistry, Multidisciplinary
Xueqin Huang, Lingzhi Chen, Tianjian Sha, Yongjian Lin, Runmin Zeng, Jun Xu, Shanze Chen, Huai-Hong Cai, Jianglin Zhang, Haibo Zhou, Ping-Hua Sun, Xingyu Jiang
Summary: This study presents a sensing platform for melanoma screening that combines a wearable microneedle patch and nanoparticles. The platform can detect real-time changes of tyrosinase in human skin and distinguish melanoma patients from normal individuals, providing potential clinical significance for early diagnosis and monitoring of cutaneous melanoma.
Article
Engineering, Environmental
Yiqian Wang, Yuzhi Qiu, Sihan Chen, Jinzhao Huang, Xiuwen Hu, Jiawen Chen, Sheng Wang, Xiangliang Yang, Yan Zhang, Yanhong Zhu
Summary: Functionalized biomimetic photoactivatable nanotherapeutics are designed to enhance the anti-tumor effects and reduce side effects by improving targeting and spatiotemporally controllable releasing capabilities. This approach combines melittin and chemotherapeutics to achieve targeted therapy and controlled drug release, resulting in significant inhibition of tumor growth with reduced side effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Astronomy & Astrophysics
Jian-Jian He, Zheng-Hua An, Wen-Xi Peng, Xin-Qiao Li, Shao-Lin Xiong, Da-Li Zhang, Rui Qiao, Dong-Ya Guo, Ce Cai, Zhi Chang, Can Chen, Gang Chen, Yuan-Yuan Du, Min Gao, Rui Gao, Ke Gong, Dong-Jie Hou, Chao-Yang Li, Gang Li, Lu Li, Mao-Shun Li, Xiao-Bo Li, Xu-Fang Li, Yan-Guo Li, Xiao-Hua Liang, Jia-Cong Liu, Xiao-Jing Liu, Ya-Qing Liu, Hong Lu, Xiang Ma, Bin Meng, Feng Shi, Li-Ming Song, Xi-Lei Sun, Chen-Wei Wang, Hui Wang, Hui-Zhen Wang, Jin-Zhou Wang, Yu-Sa Wang, Xing Wen, Xiang-Yang Wen, Shuo Xiao, Yan-Bing Xu, Yu-Peng Xu, Wang-Chen Xue, Jia-Wei Yang, Sheng Yang, Qi-Bin Yi, Cheng-Mo Zhang, Chao-Yue Zhang, Fan Zhang, Fei Zhang, Peng Zhang, Shuang-Nan Zhang, Yan-Qiu Zhang, Xiao-Yun Zhao, Yi Zhao, Chao Zheng, Shi-Jie Zheng, Xing Zhou, Yue Zhu
Summary: This study focuses on the calibration of the energy response and detection efficiency of the gamma-ray detector in the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor mission. The calibration results show that the detector meets the flight requirements and agrees with simulations.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hao Tian, Xue-Bin Zhang, Yin-Ping Li, Qing He, Na-Na Tian, Song-Hai Wu, Xu Han
Summary: This study provides evidence for the presence of Fe(IV)=O oxo and Fe(III)-OOH peroxo as key oxidizing species in the oxidation of As(III). It also reveals that the presence of doped Cu/Co ions significantly affects the formation of these oxidizing species on the surfaces of ferrihydrite and hematite.
ACS EARTH AND SPACE CHEMISTRY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Xinyue Zhu, Ruixin Zhu, Wenxing Gao, Wenjing Yin, Lixin Zhu, Na Jiao
Article
Energy & Fuels
Ming Yang, Wanyu Ge, Zirui Liu, Qiang Yue, Jun Zhang, Yanping Lv, Hao Wu
Summary: Alkali-assisted Mo doped Ni-Mn layered double hydroxides exhibit high catalytic activity in the urea oxidation reaction, achieving high current density and specific current activity. Both indirect electrochemical and direct urea oxidation processes occur when using Mo-NiMnLDH-OH as catalyst. This study provides a new approach for developing efficient catalysts for UOR.
Article
Biotechnology & Applied Microbiology
Kai Yang, Hongmei Li, Ling Li, Zhongjuan Zhao, Jindong Hu, Yanli Wei, Hetong Yang, Jishun Li
Summary: This study investigated the effects of liquid co-cultivation of Arthrobacter ureafaciens DnL1-1 and Trichoderma harzianum LTR-2 on the metabolome of fermentation liquors. The results showed significant changes in the abundance of metabolites in the fermentation liquors compared to single-cultured strains, and the co-cultivation had significant promoting effects on wheat germination and radicle length.
INTERNATIONAL MICROBIOLOGY
(2023)