(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

Regulation and dysregulation of neuronal circuits by KARs

(2021) Christophe Mulle et al.   NEUROPHARMACOLOGY

Structural and compositional diversity in the kainate receptor family

(2021) Purushotham Selvakumar et al.   Cell Reports

A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors

(2020) Silke Kayser et al.   ACS Chemical Neuroscience

Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)–H Activation Strategy and Structure–Activity Relationship Studies at the Ionotropic Glutamate Receptors

(2020) Silke Kayser et al.   ACS Chemical Neuroscience

Design and Synthesis of 2,3-trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

(2019) Christian B. M. Poulie et al.   ACS Chemical Neuroscience

Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors

(2018) Haigen Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

(2017) Anja Probst Larsen et al.   MOLECULAR PHARMACOLOGY

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

Lessons from crystal structures of kainate receptors

(2017) Stine Møllerud et al.   NEUROPHARMACOLOGY

Structure and symmetry inform gating principles of ionotropic glutamate receptors

(2017) Shujia Zhu et al.   NEUROPHARMACOLOGY

Synthesis and pharmacological characterization of the selective GluK1 radioligand (S)-2-amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)

(2016) Anna Alcaide et al.   MedChemComm

Physiopathology of kainate receptors in epilepsy

(2015) Valérie Crépel et al.   CURRENT OPINION IN PHARMACOLOGY

Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

(2014) Niklas Sköld et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Assembly of AMPA receptors: mechanisms and regulation

(2014) Quan Gan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Contribution of Aberrant GluK2-Containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy

(2014) Angélique Peret et al.   Cell Reports

Heterocycles as Nonclassical Bioisosteres of α-Amino Acids

(2013) Christian B. M. Poulie et al.   ChemMedChem

Chemoenzymatic Synthesis of New 2,4-syn-Functionalized (S)-Glutamate Analogues and Structure–Activity Relationship Studies at Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

(2013) Zeinab Assaf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kainate Receptors in Health and Disease

(2013) Juan Lerma et al.   NEURON

Selective Block of Postsynaptic Kainate Receptors Reveals Their Function at Hippocampal Mossy Fiber Synapses

(2012) Paulo S. Pinheiro et al.   CEREBRAL CORTEX

chemicalize.orgchemicalize.orgby ChemAxon Ltd.

(2012) Matthew Swain   Journal of Chemical Information and Modeling

Investigation of the interaction of gold(III)–alkyldiamine complexes with l-histidine and imidazole ligands by 1H and 13C NMR, and UV spectrophotometry

(2010) Bassem A. Al-Maythalony et al.   INORGANICA CHIMICA ACTA

Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxazolol Glutamate Receptor Agonist Ibotenic Acid

(2010) Karla Frydenvang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

4,4-Dimethyl- and Diastereomeric 4-Hydroxy-4-methyl- (2S)-Glutamate Analogues Display Distinct Pharmacological Profiles at Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

(2009) Lennart Bunch et al.   ChemMedChem

Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors — Focus on subtypes iGlu5–7

(2009) Lennart Bunch et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE