Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of small interfering RNA targeting sphingosine kinase-1 gene on the animal model of Alzheimer’s disease

(2013) Yuan Zhang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

(2013) Celina Wu et al.   Journal of Neuroinflammation

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

(2013) Nobumasa Takasugi et al.   PLoS One

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

(2012) Ruben van Doorn et al.   Journal of Neuroinflammation

Sphingosine Kinase 1 Mediation of Expression of the Anaphylatoxin Receptor C5L2 Dampens the Inflammatory Response to Endotoxin

(2012) Kurt Bachmaier et al.   PLoS One

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation

(2012) Natalia M. Grin’kina et al.   PLoS One

Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury

(2011) SunJa Kim et al.   BRAIN PATHOLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

(2011) Iris Fischer et al.   PLoS One

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

S1P metabolism in cancer and other pathological conditions

(2010) Weng In Leong et al.   BIOCHIMIE

Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics

(2010) M.R. Pitman et al.   CURRENT CANCER DRUG TARGETS

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation

(2010) David J. Swan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus

(2010) T. Kanno et al.   NEUROSCIENCE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia

(2009) D. Nayak et al.   NEUROSCIENCE

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

(2007) Samar M. Hammad et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS