Prokaryotic 2-component systems and the OmpR/PhoB superfamily

Free energy landscape of activation in a signalling protein at atomic resolution

(2015) F. Pontiggia et al.   Nature Communications

A network of molecular switches controls the activation of the two-component response regulator NtrC

(2015) Dan K. Vanatta et al.   Nature Communications

Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions

(2014) Wei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence Against the “Y–T Coupling” Mechanism of Activation in the Response Regulator NtrC

(2014) Janice Villali et al.   JOURNAL OF MOLECULAR BIOLOGY

Atypical Response Regulator ChxR from Chlamydia trachomatis Is Structurally Poised for DNA Binding

(2014) Michael L. Barta et al.   PLoS One

Crosstalk and the evolution of specificity in two-component signaling

(2014) M. A. Rowland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

(2014) Felipe Trajtenberg et al.   mBio

Bacterial Regulon Evolution: Distinct Responses and Roles for the Identical OmpR Proteins of Salmonella Typhimurium and Escherichia coli in the Acid Stress Response

(2014) Heather J. Quinn et al.   PLoS Genetics

Analysis of DNA interactions using single-molecule force spectroscopy

(2013) Markus Ritzefeld et al.   AMINO ACIDS

Determinants of specificity in two-component signal transduction

(2013) Anna I Podgornaia et al.   CURRENT OPINION IN MICROBIOLOGY

The Cpx Stress Response System Potentiates the Fitness and Virulence of Uropathogenic Escherichia coli

(2013) Irina Debnath et al.   INFECTION AND IMMUNITY

A Link between Dimerization and Autophosphorylation of the Response Regulator PhoB

(2013) Rachel L. Creager-Allen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Analysis of OmpR Phosphorylation, Dimerization, and DNA Binding Supports a Canonical Model for Activation

(2013) Christopher M. Barbieri et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Evolution of Two-Component Signal Transduction Systems

(2012) Emily J. Capra et al.   Annual Review of Microbiology

Insights into the mechanism of activation of the phosphorylation-independent response regulator NblR. Role of residues Cys69 and Cys96

(2012) Javier Espinosa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families

(2012) Emily J. Capra et al.   CELL

Structure-Function Studies of DNA Binding Domain of Response Regulator KdpE Reveals Equal Affinity Interactions at DNA Half-Sites

(2012) Anoop Narayanan et al.   PLoS One

Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling

(2012) R. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of the periplasmic domain ofVibrio parahaemolyticusCpxA

(2012) Eunju Kwon et al.   PROTEIN SCIENCE

A Fundamental Regulatory Mechanism Operating through OmpR and DNA Topology Controls Expression of Salmonella Pathogenicity Islands SPI-1 and SPI-2

(2012) Andrew D. S. Cameron et al.   PLoS Genetics

The structural basis of the response regulator DrRRA from Deinococcus radiodurans

(2011) Ying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the Response Regulator PhoP fromMycobacterium tuberculosisReveals a Dimer through the Receiver Domain

(2011) Smita Menon et al.   BIOCHEMISTRY

Two-Component Systems and Their Co-Option for Eukaryotic Signal Transduction

(2011) G. Eric Schaller et al.   CURRENT BIOLOGY

The Atypical Response Regulator Protein ChxR Has Structural Characteristics and Dimer Interface Interactions That Are Unique within the OmpR/PhoB Subfamily

(2011) John M. Hickey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receiver domain structure and function in response regulator proteins

(2010) Robert B Bourret   CURRENT OPINION IN MICROBIOLOGY

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

The ArcB Sensor Kinase of Escherichia coli Autophosphorylates by an Intramolecular Reaction

(2010) G. R. Pena-Sandoval et al.   JOURNAL OF BACTERIOLOGY

The Complexities of Porin Genetic Regulation

(2010) Miguel Ángel De la Cruz et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

P2CS: a database of prokaryotic two-component systems

(2010) Mohamed Barakat et al.   NUCLEIC ACIDS RESEARCH

Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex

(2010) Christian H. Bell et al.   PLOS BIOLOGY

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

(2010) Emily J. Capra et al.   PLoS Genetics

Biological Insights from Structures of Two-Component Proteins

(2009) Rong Gao et al.   Annual Review of Microbiology

P2CS: a two-component system resource for prokaryotic signal transduction research

(2009) Mohamed Barakat et al.   BMC GENOMICS

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Hydrophobic peptides: novel regulators within bacterial membrane

(2009) Eric Alix et al.   MOLECULAR MICROBIOLOGY

Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases

(2009) Daelynn R. Buelow et al.   MOLECULAR MICROBIOLOGY

The MiST2 database: a comprehensive genomics resource on microbial signal transduction

(2009) Luke E. Ulrich et al.   NUCLEIC ACIDS RESEARCH

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rewiring the Specificity of Two-Component Signal Transduction Systems

(2008) Jeffrey M. Skerker et al.   CELL

Signal integration in bacterial two-component regulatory systems

(2008) A. Y. Mitrophanov et al.   GENES & DEVELOPMENT

Amino Acids Important for DNA Recognition by the Response Regulator OmpR

(2008) Jee Eun Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-independent activation of the atypical response regulator NblR

(2008) D. Ruiz et al.   MICROBIOLOGY-SGM

System-level mapping ofEscherichia coliresponse regulator dimerization with FRET hybrids

(2008) Rong Gao et al.   MOLECULAR MICROBIOLOGY

Cross-talk suppression between the CpxA-CpxR and EnvZ-OmpR two-component systems inE. coli

(2008) Albert Siryaporn et al.   MOLECULAR MICROBIOLOGY

Identification of direct residue contacts in protein-protein interaction by message passing

(2008) M. Weigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Water-mediated interactions between DNA and PhoB DNA-binding/transactivation domain: NMR-restrained molecular dynamics in explicit water environment

(2008) Tsutomu Yamane et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding

(2008) David J. Sidote et al.   STRUCTURE