Precision medicine in bronchiectasis

Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia

(2021) Amelia Shoemark et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

(2021) Holly R Keir et al.   Lancet Respiratory Medicine

Integrative microbiomics in bronchiectasis exacerbations

(2021) Micheál Mac Aogáin et al.   NATURE MEDICINE

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

(2021) Andrew Menzies-Gow et al.   NEW ENGLAND JOURNAL OF MEDICINE

The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study

(2021) Alison J Dicker et al.   Lancet Respiratory Medicine

T2-High Endotype and Response to Biological Treatments in Patients with Bronchiectasis

(2021) Martina Oriano et al.   Biomedicines

The Relationship Between Symptoms, Exacerbations and Treatment Response in Bronchiectasis

(2020) Yong-hua Gao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhaled Aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a post-hoc analysis of the AIR-BX studies

(2020) Megan L. Crichton et al.   EUROPEAN RESPIRATORY JOURNAL

Blood eosinophils predict inhaled fluticasone response in bronchiectasis

(2020) Stefano Aliberti et al.   EUROPEAN RESPIRATORY JOURNAL

The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease

(2020) Alison J. Dicker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

(2020) Luis Carreto et al.   THORAX

Sputum Neutrophil Elastase associates with microbiota and P. aeruginosa in bronchiectasis

(2020) Martina Oriano et al.   EUROPEAN RESPIRATORY JOURNAL

Changes in respiratory symptoms during 48 weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies

(2020) James D Chalmers et al.   EUROPEAN RESPIRATORY JOURNAL

Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline

(2020) Charles L. Daley et al.   EUROPEAN RESPIRATORY JOURNAL

The efficacy of inhaled hypertonic saline for bronchiectasis: a meta-analysis of randomized controlled studies

(2020) Bingfeng Xie et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

(2020) James D. Chalmers et al.   NEW ENGLAND JOURNAL OF MEDICINE

The clinical impact of pseudomonas aeruginosa eradication in bronchiectasis in a Dutch referral center

(2019) A. Pieters et al.   EUROPEAN RESPIRATORY JOURNAL

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials

(2019) Charles S Haworth et al.   Lancet Respiratory Medicine

Treatable Traits: a new paradigm for 21st century management of chronic airway diseases

(2019) Vanessa M. McDonald et al.   EUROPEAN RESPIRATORY JOURNAL

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019

(2019) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

(2019) Oriol Sibila et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Muco-Obstructive Lung Diseases

(2019) Richard C. Boucher   NEW ENGLAND JOURNAL OF MEDICINE

A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

(2019) Amelia Shoemark et al.   EUROPEAN RESPIRATORY JOURNAL

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

(2019) Oriol Sibila et al.   THORAX

A longitudinal characterization of the Non-Cystic Fibrosis Bronchiectasis airway microbiome

(2019) T. E. Woo et al.   Scientific Reports

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

(2019) Raja Dhar et al.   Lancet Global Health

The microbiome in bronchiectasis

(2019) Hollian Richardson et al.   European Respiratory Review

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

(2019) Kathryn A Ramsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-IL5 and anti-IL5Rα therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series

(2019) Jessica Rademacher et al.   EUROPEAN RESPIRATORY JOURNAL

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

(2019) Peter G. Middleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

(2019) James D Chalmers et al.   Lancet Respiratory Medicine

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis

(2019) Irena F Laska et al.   Lancet Respiratory Medicine

Primary ciliary dyskinesia in the genomics age

(2019) Jane S Lucas et al.   Lancet Respiratory Medicine

Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques

(2019) Martina Oriano et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

RESPIRE: breathing new life into bronchiectasis

(2018) Sanjay H. Chotirmall et al.   EUROPEAN RESPIRATORY JOURNAL

Blood eosinophil levels as a biomarker in COPD

(2018) Guy Brusselle et al.   RESPIRATORY MEDICINE

Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials

(2018) Mona Bafadhel et al.   Lancet Respiratory Medicine

Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study

(2018) David E Griffith et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The overlap between bronchiectasis and chronic airway diseases: state of the art and future directions

(2018) Eva Polverino et al.   EUROPEAN RESPIRATORY JOURNAL

Treatable traits in bronchiectasis

(2018) Rita Boaventura et al.   EUROPEAN RESPIRATORY JOURNAL

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

(2018) Patrick A Flume et al.   LANCET

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

(2018) Martina Contarini et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Pulmonary rehabilitation in bronchiectasis: a propensity-matched study

(2018) Suhani Patel et al.   EUROPEAN RESPIRATORY JOURNAL

A comprehensive approach to lung function in bronchiectasis

(2018) Dejan Radovanovic et al.   RESPIRATORY MEDICINE

British Thoracic Society Guideline for bronchiectasis in adults

(2018) Adam T Hill et al.   THORAX

Efficacy ofPseudomonas aeruginosaeradication regimens in bronchiectasis

(2017) Emilie Vallières et al.   EUROPEAN RESPIRATORY JOURNAL

Pseudomonas aeruginosaadaptation and diversification in the non-cystic fibrosis bronchiectasis lung

(2017) Yasmin Hilliam et al.   EUROPEAN RESPIRATORY JOURNAL

Precision medicine in airway diseases: moving to clinical practice

(2017) Alvar Agustí et al.   EUROPEAN RESPIRATORY JOURNAL

The microbiome in respiratory medicine: current challenges and future perspectives

(2017) Rosa Faner et al.   EUROPEAN RESPIRATORY JOURNAL

European Respiratory Society guidelines for the management of adult bronchiectasis

(2017) Eva Polverino et al.   EUROPEAN RESPIRATORY JOURNAL

Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients

(2017) Michael J. Cox et al.   PLoS One

Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration

(2016) Stefano Aliberti et al.   EUROPEAN RESPIRATORY JOURNAL

European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia

(2016) Jane S. Lucas et al.   EUROPEAN RESPIRATORY JOURNAL

A longitudinal study characterising a large adult primary ciliary dyskinesia population

(2016) Anand Shah et al.   EUROPEAN RESPIRATORY JOURNAL

Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study

(2016) Melissa J McDonnell et al.   Lancet Respiratory Medicine

Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis

(2016) Ritesh Agarwal et al.   Expert Review of Respiratory Medicine

Sputum bacteriology in steady-state bronchiectasis in Guangzhou, China

(2015) W-J. Guan et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Eradication Therapy against Pseudomonas aeruginosa in Non-Cystic Fibrosis Bronchiectasis

(2015) Ramon Orriols et al.   RESPIRATION

Non cystic fibrosis bronchiectasis: A longitudinal retrospective observational cohort study of Pseudomonas persistence and resistance

(2015) Melissa J. McDonnell et al.   RESPIRATORY MEDICINE

The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease

(2015) Robert P. Dickson et al.   PLoS Pathogens

Lung disease in primary antibody deficiency

(2015) Nisha Verma et al.   Lancet Respiratory Medicine

Inhaled Colistin in Patients with Bronchiectasis and ChronicPseudomonas aeruginosaInfection

(2014) Charles S. Haworth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Bronchiectasis Severity Index. An International Derivation and Validation Study

(2014) James D. Chalmers et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function

(2014) C. Nair et al.   EUROPEAN RESPIRATORY JOURNAL

Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial

(2014) Diana Bilton et al.   THORAX

Quality of Life Questionnaire-Bronchiectasis: final psychometric analyses and determination of minimal important difference scores

(2014) Alexandra L Quittner et al.   THORAX

Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials

(2014) Alan F Barker et al.   Lancet Respiratory Medicine

The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind, placebo-controlled BLESS trial

(2014) Geraint B Rogers et al.   Lancet Respiratory Medicine

Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition

(2013) Geraint B Rogers et al.   THORAX

Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non–Cystic Fibrosis Bronchiectasis

(2012) James D. Chalmers et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis

(2012) James D. Chalmers et al.   MOLECULAR IMMUNOLOGY

Pulmonary Nontuberculous Mycobacterial Disease Prevalence and Clinical Features

(2010) Kevin L. Winthrop et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET