Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Biochemistry & Molecular Biology
Lihu Xie, Xiaoping Long, Meili Mo, Jinmei Jiang, Qingxiu Zhang, Mei Long, Mei Li
Summary: This study investigates the role of bone marrow mesenchymal stem cell-derived exosome (BMSC-Exos) delivering miR-214 in systemic sclerosis (SSc) and its relationship with the IL-33/ST2 axis.
MOLECULAR IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Xiaoxuan Zhao, Mingxi Xu, Xuemeng Hu, Xiaolei Ding, Xian Zhang, Liye Xu, Li Li, Xiuhua Sun, Jincheng Song
Summary: This study investigates the role of exosomes derived from human bone marrow mesenchymal stem cells (hBMSCs) carrying microRNA-124-3p in the development of diffuse large B cell lymphoma (DLBCL). It is found that miR-124-3p negatively regulates the expression of NFATc1, inhibiting DLBCL cell proliferation and promoting apoptosis. Through downregulation of NFATc1, hBMSC-miR-124-3p represses the development of DLBCL.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Xianghao Ma, Ruibo Sun, Youwen Liu, Wuyin Li
Summary: The study demonstrates that BMSC-exo carrying miR-935 promotes osteoblast proliferation and differentiation through targeting STAT1.
Article
Immunology
Zheng Wu, Shujuan Cheng, Shaoping Wang, Wenzheng Li, Jinghua Liu
Summary: The study showed that exosomal miR-150-5p derived from bone marrow mesenchymal stem cells can attenuate cardiomyocyte apoptosis through targeting Bax and improve cardiac function in myocardial infarction mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Zhiwen Luo, Yaying Sun, Beijie Qi, Jinrong Lin, Yisheng Chen, Yuzhen Xu, Jiwu Chen
Summary: The study found that bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) can significantly inhibit the fibrogenic process in shoulder capsule fibrosis. BMSC-EVs suppressed abnormal proliferation and high collagen production in fibroblasts, improving shoulder mobility. The let-7a-5p molecule in BMSC-EVs was found to have anti-fibrotic effects by targeting TGFBR1 gene.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Qiting He, Ruibin Li, Beibei Hu, Xuezhou Li, Yunpeng Wu, Pengfei Sun, Yuhua Jia, Yongyuan Guo
Summary: Our study clarified the role of the lncRNA-H19/miR-214-5p/BMP2 axis in the osteoblastic differentiation of hBMMSCs induced by SDF-1. The results indicated that SDF-1 promotes osteoblastic differentiation through the lncRNA-H19/miR-214-5p/BMP2 axis, and an miR-214-5p inhibitor could potentially be used as a new strategy for the treatment of bone defect and osteoporosis.
JOURNAL OF GENE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Feng Lin, Suihao Zhang, Xia Liu, Meishan Wu
Summary: Exosomal miR-125b-5p from BMSCs inhibits atherosclerotic plaque formation by targeting Map4k4 expression, leading to reduced inflammation, decreased blood lipid levels, smaller plaque areas, increased expression of smooth muscle cell marker α-SMA, as well as inhibition of apoptosis in AS mice.
Article
Biochemistry & Molecular Biology
Xueke Li, Yi Zhong, Wuqi Zhou, Yishu Song, Wenqu Li, Qiaofeng Jin, Tang Gao, Li Zhang, Mingxing Xie
Summary: LIPUS stimulation on BMSCs increases the secretion of EVs, which possess stronger anti-inflammatory function. RNA-seq analysis reveals upregulation of miR-328-5p and miR-487b-3p in LIPUS-EVs, potentially suppressing the MAPK signaling pathway to enhance the anti-inflammatory effects.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Anatomy & Morphology
Xiaodong Mao, Zhi Li, Shaofang Gu, Wei Song, Mimi Zhang, Xiao Tan, Ziqing Mao
Summary: This study investigates the mechanism of miR-211-5p in extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) in improving frozen shoulder (FS) in rat models. BMSCs-EVs were extracted and injected into the rats, which improved the activity of the glenohumeral joints and the pathological condition of joint capsule. It was found that miR-211-5p in BMSCs-EVs increased H3K4me3 methylation in shoulder capsule tissue by binding KDM2B, resulting in up-regulated transcription level of LACC1.
Article
Cell Biology
Sha Sha, Xueli Shen, Yunpeng Cao, Le Qu
Summary: The study demonstrated the therapeutic effects of BM-MSC-EVs on AD rats and neurons, by delivering miR-29c-3p to neurons to inhibit BACE1 expression and activate the Wnt/beta-catenin pathway. This may provide a novel perspective for understanding the mechanism of MSCs in the treatment of AD.
Article
Neurosciences
Meixiong Cheng, Ling Liu, Tian Zhang, Yong Chen, Qi Wang, Yaqiu Wu
Summary: BMSC-EVs attenuated neurological deficits and endothelial dysfunction after SAH via regulating the KLF3-AS1/miR-183-5p/TCF7L2 signaling axis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Dewang Fu, Ben Liu, Huamao Jiang, Zhaowei Li, Chenghui Fan, Li'e Zang
Summary: The research demonstrates that exosomal miR-19b-1-5p can suppress bladder cancer growth by decreasing ABL2, and it also inhibits malignant behaviors of bladder cancer cells.
Article
Cell Biology
Huamei Wei, Jianchu Wang, Zuoming Xu, Wenchuan Li, Xianjian Wu, Chenyi Zhuo, Yuan Lu, Xidai Long, Qianli Tang, Jian Pu
Summary: HepG2-EVs were found to promote differentiation of BMSCs into fibroblasts, leading to enhanced liver cancer growth and metastasis. miR-181d-5p was identified to play a role in this process by targeting SOCS3 through the FAK/Src pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)