Review
Rheumatology
Anand Kumthekar, Maedeh Ashrafi, Atul Deodhar
Summary: Psoriatic arthritis (PsA) is a chronic, multi-domain immune-mediated inflammatory arthritis with a high disease burden. Despite the availability of multiple therapeutic agents, it is not uncommon to find patients not responding adequately and continuing to have active disease and/or high disease burden.
CLINICAL RHEUMATOLOGY
(2023)
Review
Cell Biology
Christine J. Watson
Summary: Research on mammary stem cells is currently facing controversies, but with innovative experimental approaches and technologies, there is a reevaluation of the concept of stem and progenitor cell hierarchy in progress.
TRENDS IN CELL BIOLOGY
(2021)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Neurosciences
Nick J. Spencer, Tim Hibberd, Zili Xie, Hongzhen Hu
Summary: In recent years, there has been increasing interest in understanding the communication between the gut and the brain. New data suggests that the sensory nerve pathways between the two may have a more significant impact on health and disease than previously assumed. While sensory nerve endings in the skin have been extensively studied, there is a lack of knowledge about most types of visceral afferents, especially those that innervate abdominal organs like the gut. Recent studies have identified nerve endings of spinal afferents in visceral organs, emphasizing their role in pain perception from the gut to the brain. Surprisingly, the majority of these spinal afferent nerve endings in the gut express the TRPV1 ion channel, commonly associated with nociceptive neurons. Furthermore, these nerve endings are activated at low thresholds within the normal physiological range, suggesting a complex nature of visceral nociception. This highlights the need to redefine nociceptors in the gut, which may involve multiple morphological types of spinal afferent nerve endings.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Dafna D. Gladman
Summary: The prevalence of axial psoriatic arthritis (axPsA) is estimated at 40-50%, and recent studies suggest it has distinct features from ankylosing spondylitis. Due to the lack of a widely accepted definition of axPsA, designing therapeutic trials for this type of PsA has been challenging, but some recent trials indicate that treatments effective for peripheral arthritis may also be effective for axPsA.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Review
Medicine, General & Internal
Loredana Sabina Pascu, Nicolae Sarbu, Andrei Vlad Bradeanu, Daniela Jicman (Stan), Madalina Nicoleta Matei, Mihaela Ionela Sarbu, Doina Carina Voinescu, Aurel Nechita, Alin Laurentiu Tatu
Summary: Psoriatic arthritis is a clinically significant disease with a high prevalence and overlapping symptoms with other spondylarthritis disorders. Understanding the MRI manifestations and implementing a multidisciplinary strategy is crucial for effective management.
Editorial Material
Rheumatology
Stanley B. Cohen
Summary: JAK inhibitors are now a standard treatment for rheumatoid arthritis patients, but concerns about an increased risk of venous thromboembolism have tempered enthusiasm for their use in clinical settings.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Clinical Neurology
Nirosen Vijiaratnam, Thomas Foltynie
Summary: The recent validation of the alpha-synuclein seed amplification assay as a biomarker for the diagnosis of Parkinson's disease has provided a basis for a proposed staging system in clinical studies. However, further challenges exist in finding biomarkers for disease modifying agents, including optimizing distinction between different alpha-synucleinopathies and predicting clinical benefit. The use of additional biomarkers, such as CSF proteins and imaging techniques, may enhance trial planning and assessment of interventions.
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Shan-Shan Li, Na Du, Shi-Hao He, Xu Liang, Tian-Fang Li
Summary: This study found that patients with axial psoriatic arthritis (axPsA) who had dactylitis had higher disease activity and more severe joint damage compared to those without dactylitis. Careful examination and proper management of axial involvement are recommended.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Denis Poddubnyy, Deepak R. Jadon, Filip Van den Bosch, Philip J. Mease, Dafna D. Gladman
Summary: Psoriatic arthritis (PsA) is a chronic, inflammatory musculoskeletal disease with heterogeneous characteristics, and axial involvement can lead to complications in management and treatment decisions. The lack of agreed-upon classification and diagnostic criteria for axial PsA complicates the approach to this subset of patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Review
Medicine, General & Internal
Kate Harnden, Andrea Di Matteo, Kulveer Mankia
Summary: In recent years, rheumatologists have shifted their focus to studying individuals at risk of developing rheumatoid arthritis (RA) rather than just early RA. The use of blood, clinical, and imaging biomarkers can now identify those at risk of progression before the onset of clinical symptoms. Imaging techniques, such as ultrasound and magnetic resonance imaging, have been widely used to understand the pathogenesis of RA and identify individuals at high risk of progression.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
D. Benavent, Ch Plasencia, D. Poddubnyy, M. Kishimoto, F. Proft, H. Sawada, C. Lopez-Medina, M. Dougados, V Navarro-Compan
Summary: In this worldwide study, axial PsA was defined as a unique phenotype by rheumatologists, with disease features falling between axSpA and pure pPsA.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
