Critical evaluation of challenges and future use of animals in experimentation for biomedical research

Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research

(2015) Susan Bridgwood Green   BMC Medical Ethics

The fickle P value generates irreproducible results

(2015) Lewis G Halsey et al.   NATURE METHODS

Estimating the predictive validity of diabetic animal models in rosiglitazone studies

(2015) O. E. Varga et al.   Obesity Reviews

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

The Impact of Preclinical Irreproducibility on Drug Development

(2015) LP Freedman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

(2014) Emily S Sena et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increasing value and reducing waste: addressing inaccessible research

(2014) An-Wen Chan et al.   LANCET

How to increase value and reduce waste when research priorities are set

(2014) Iain Chalmers et al.   LANCET

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Policy: NIH plans to enhance reproducibility

(2014) Francis S. Collins et al.   NATURE

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

(2014) Judith van Luijk et al.   PLoS One

Of rodents and men: Species-specific glucose regulation and type 2 diabetes research

(2014) P. Charukeshi Chandrasekera   ALTEX-Alternatives to Animal Experimentation

Endpoint Matrix: a conceptual tool to promote consideration of the multiple dimensions of humane endpoints

(2014) Vanessa Ashall   ALTEX-Alternatives to Animal Experimentation

Statistical power, effect size and animal welfare: recommendations for good practice

(2013) D Hawkins et al.   ANIMAL WELFARE

Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development

(2013) Hugo Geerts et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Neuroscience: Through the eyes of a mouse

(2013) Monya Baker   NATURE

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease

(2013) Hugo Geerts et al.   Frontiers in Pharmacology

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Drug development and clinical trials—the path to an approved cancer drug

(2012) Eric H. Rubin et al.   Nature Reviews Clinical Oncology

Animal Welfare in Studies on Murine Tuberculosis: Assessing Progress over a 12-Year Period and the Need for Further Improvement

(2012) Nuno Henrique Franco et al.   PLoS One

Extrapolating from Animals to Humans

(2012) J. P. A. Ioannidis   Science Translational Medicine

Tracking Replicability as a Method of Post-Publication Open Evaluation

(2012) Joshua K. Hartshorne et al.   Frontiers in Computational Neuroscience

A search filter for increasing the retrieval of animal studies in Embase

(2011) Rob B M de Vries et al.   LABORATORY ANIMALS

A step-by-step guide to systematically identify all relevant animal studies

(2011) Marlies Leenaars et al.   LABORATORY ANIMALS

Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed

(2010) Carlijn R Hooijmans et al.   LABORATORY ANIMALS

Improving the translational hit of experimental treatments in multiple sclerosis

(2010) Hanna M Vesterinen et al.   Multiple Sclerosis Journal

Raising the bar for cancer therapy models

(2010) Giulio Francia et al.   NATURE BIOTECHNOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Is the use of sentient animals in basic research justifiable?

(2010) Ray Greek et al.   Philosophy Ethics and Humanities in Medicine

Why Are So Many Epidemiology Associations Inflated or Wrong? Does Poorly Conducted Animal Research Suggest Implausible Hypotheses?

(2009) Michael B. Bracken   ANNALS OF EPIDEMIOLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE