Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Orthopedics
Tony Chen, Caroline Brial, Moira McCarthy, Russell F. Warren, Suzanne A. Maher
Summary: The study found that femoral osteochondral defects cause a redistribution of contact stress during simulated gait. The results showed that polyvinyl alcohol implants combined with porous metal bases can significantly improve joint contact mechanics, especially the implants consisting of a 20% PVA disk mounted on a pTi base demonstrated significant improvements in most parameters.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ran Yang, Xu Zhang, Jiahui Liu, Xiaoyuan Li, Dongfang Zhou, Shifang Luan
Summary: A chemically modified gelatin hydrogel scaffold (GelMA-AG) is proposed and prepared in this study, which can release glutamine to activate the energy metabolism process of chondrocytes and effectively promote damaged cartilage repair. The results demonstrate that GelMA-AG increases mitochondrial membrane potential and intracellular ATP production, decreases intracellular reactive oxygen species in chondrocytes, and improves cellular metabolism and reduces inflammation in cartilage tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yisi Liu, Meng Wang, Yixuan Luo, Qianyi Liang, Yin Yu, Fei Chen, Jun Yao
Summary: Stem cells hold promise for cartilage repair in osteoarthritis, but challenges in large-scale production, viability maintenance, and therapeutic activity hinder clinical application. Advanced hydrogel technologies, particularly microgels and dynamic hydrogel systems, show potential in improving stem cell survival and regulation of stem cell fate.
Review
Materials Science, Multidisciplinary
Heng Li, Chengwei Wu, Xiaogang Yu, Wei Zhang
Summary: Articular cartilage is essential for knee joint motion, acting as a connective tissue to distribute loads and withstand high-stress loadings. However, its self-repair capacity is limited due to the absence of vascular, neural, and lymphatic tissues. Therefore, the development of new approaches and materials for cartilage repair is crucial.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Review
Medicine, Research & Experimental
Hui Zhang, Jianghong Huang, Murad Alahdal
Summary: This article provides a comprehensive overview of the potential of hydrogel bioprinting and exosome-based therapy in the treatment of osteoarthritis (OA). Combining immune regulatory exosomes with three-dimensional bioprinting hydrogel holds promise for immunomodulating cartilage tissue and treating OA. It emphasizes the potential of three-dimensional bioprinting hydrogel loaded with chondrogenic stimuli agents for OA treatment, serving as a basis for further research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Qi Zhang, Huaxing Xu, Chu Wu, Yinghui Shang, Qing Wu, Qingcong Wei, Yao Sun, Qigang Wang
Summary: The article discusses a new method for achieving fast gelation through enzyme-catalyzed polymerization, which leads to rapid enhancement of soft tissues through the production of carbon radicals and macromolecules, demonstrating the promoting capacity of cartilage regeneration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Huangrong Zhu, Fengling Liu, Xinrang Zhai, Zhicheng Tong, Huimin Li, Wei Dong, Wei Wei, Chong Teng
Summary: Considering the increasing incidence of knee osteoarthritis, the repair of cartilage defects has become more important. This study constructed a biomacromolecule-based bioadhesive hydrogel and successfully applied it to promote cartilage regeneration, showing promising potential for cartilage repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Wenxiang Zhu, Zheng Zhou, Yuting Huang, Hairong Liu, Ning He, Xiaolong Zhu, Xiaoxiao Han, Dengming Zhou, Xuanchu Duan, Xin Chen, Yahui He, Xiaolin Meng, Shuai Zhu
Summary: A multifunctional hydrogel composed of modified sericin and nanoparticles was developed, which exhibited photothermal activity to kill tumor cells and bacteria, as well as antioxidative properties and good biocompatibility. The hydrogel effectively repaired rabbit articular cartilage defects and promoted the regeneration of mouse skin burning wounds.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Dominique P. Pioletti
Summary: The drive to develop cartilage implants for major defects in the musculoskeletal system has led to an increased focus on developing biomaterial devices for cartilage repair. However, there has been limited attention on the preclinical validation process and approval procedures for these devices. This review paper aims to highlight the various considerations regarding preclinical validation of hydrogel devices for cartilage repair, including regulatory requirements, implantation strategies, device performance aspects, and characterizations.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Yuefeng Zhu, Le Ye, Xiaoxi Cai, Zuhao Li, Yongqian Fan, Fengjian Yang
Summary: The study suggests that hydrogels containing icariin can promote chondrogenesis and relieve pain. Loading bone marrow mesenchymal stem cells into the hydrogel shows more efficacy in preventing cartilage destruction and has significant therapeutic potential.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haobo Li, Dong Xiang, Chongcheng Gong, Xiaomin Wang, Lin Liu
Summary: A long-lasting injectable hydrogel containing EGCG and HA was prepared, which could continuously scavenge reactive oxygen species and protect ADSCs. Intra-articular injection of this hydrogel improved osteoarthritis, reduced pro-inflammatory cytokines expression, promoted cartilage repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Jian Guan, Fu-zhen Yuan, Zi-mu Mao, Hai-lin Zhu, Lin Lin, Harry Huimin Chen, Jia-kuo Yu
Summary: The 3D-printed PEGDA-GelMA-CSMA scaffolds not only possess adequate mechanical strength, but also maintain a suitable 3D microenvironment for differentiation, proliferation, and extracellular matrix production of bone marrow mesenchymal stem cells (BMSCs).
Article
Materials Science, Multidisciplinary
Ziheng Li, Binbin Wang, Qihang Xu, Deqiang You, Wei Li, Xiaojian Wang
Summary: In this study, a dual-crosslinked zwitterionic P(AAm-co-AAc-co-SBMA)/Fe3+ hydrogel was synthesized, with the introduction of SBMA to improve the hydrophilicity of the polymer chain. The hydrogel exhibited significantly improved tensile strength (9.9 MPa) and compressive strength (207.6 MPa), and achieved an ultra-low friction coefficient (CoF) of 0.04 in water. These results provide a new approach for cartilage repair materials with considerable strength and low friction.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Hui Liu, Xi Xiang, Jianbo Huang, Bihui Zhu, Liyun Wang, Yuanjiao Tang, Fangxue Du, Ling Li, Feng Yan, Lang Ma, Li Qiu
Summary: Tissue engineering technology has become a hot topic in articular cartilage repair to alleviate osteoarthritis, with hydrogel being a commonly used scaffold material that provides a good extracellular matrix microenvironment for stem cells. However, the low homing rate of stem cells limits their role in cartilage regeneration. A novel injectable chemotaxis hydrogel that combines chitosan-based hydrogel with SDF-1 alpha-loaded nanodroplets has been designed to promote stem cell homing and cartilage repair in OA, showing promising potential for future treatment strategies.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Applied
Zhixiang Cai, Yue Wei, Yalong Guo, Aiqin Ma, Hongbin Zhang
FOOD HYDROCOLLOIDS
(2020)
Article
Chemistry, Applied
Yue Wei, Yanping Xie, Zhixiang Cai, Yalong Guo, Hongbin Zhang
Summary: This study developed GMO-CFG emulsifiers with different degrees of substitution and investigated their interfacial properties, revealing that hydrophobically modified CFG can enhance stability and the ability to produce fine droplets, while esterification and its degree have significant effects on the interfacial properties.
Article
Chemistry, Applied
Yuanyuan Wei, Yalong Guo, Ruiqi Li, Aiqin Ma, Hongbin Zhang
Summary: Novel naturally sourced thickeners from food biopolymers have gained increasing attention in food areas, especially where edible safety of thickeners is crucial. The rheological behaviors of carboxymethylated curdlan and konjac glucomannan as potential thickeners for dysphagia were studied, showing unique viscosity enhancement abilities. However, a viscosity-lowering phenomenon was observed in konjac glucomannan solutions in the presence of maltodextrin, providing an advantage for incorporating more dietary fibers in dysphagia diets.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Ruiqi Li, Min Wu, Yalong Guo, Hongbin Zhang
Summary: This study comprehensively investigated the molecular characterization and solution properties of charged and uncharged CMKGM with different molecular weights and degrees of substitution. It was found that CMKGM molecules adopt semiflexible chain conformation in aqueous solutions, with a tendency towards rigid chains based on Mw and DS variations. Various rheological models and solution scaling theory were used to describe the behavior of CMKGM solutions, with different approaches providing valid results for intrinsic viscosity determination depending on the charged or uncharged nature of the molecules. Additionally, constitutive models such as the linear Maxwell model and non-linear PTT and Giesekus models were employed to quantitatively describe the rheological properties of CMKGM solutions under different flow conditions.
FOOD HYDROCOLLOIDS
(2021)
Review
Food Science & Technology
Zhixiang Cai, Yue Wei, Hongbin Zhang, Pingfan Rao, Qiang Wang
Summary: This review highlights the extraction, physicochemical properties, biological activities, and functional properties of corn fiber gum (CFG), emphasizing its emulsifying property and potential applications in the food industry. It is found that the biological activities and functional properties of CFG are closely related to its fine structural features, with the protein content and nutraceutical phenolic compound content playing significant roles in its emulsifying property. Additional chemical or physical modifications may enhance the functional properties of CFG, making it a promising ingredient in the food industry for its antioxidant, immunomodulatory, dietary fiber, and emulsifying properties.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhixiang Cai, Yanmei Tang, Yue Wei, Pengguang Wang, Hongbin Zhang
Summary: Various studies have shown that physical anti-adhesion barriers like hydrogels can effectively reduce or prevent postsurgical peritoneal adhesions, while the use of chemical cross-linkers in chemical hydrogels may lead to cytotoxicity or unwanted side effects. A physically cross-linked hyaluronan cryogel was developed as a novel anti-adhesion biomaterial, demonstrating excellent biocompatibility and preventing fibroblast penetration, with the ability to inhibit inflammatory responses and modulate the fibrinolytic system to prevent peritoneal adhesions.
Article
Nanoscience & Nanotechnology
Zhixiang Cai, Shanming Hu, Yue Wei, Tao Huang, Aishui Yu, Hongbin Zhang
Summary: The development of an in situ covalently crosslinked three-dimensional (3D) supramolecular network for silicon electrodes shows promise in improving cycling performance and overall performance of lithium-ion batteries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Yalong Guo, Min Wu, Ruiqi Li, Zhixiang Cai, Hongbin Zhang
Summary: Physically crosslinked cryogels of carboxymethylated konjac glucomannan (CMKGM) with different molecular weights and degrees of substitution were fabricated using the freeze-thaw technique. The formation and mechanical strength of the cryogels were significantly affected by the molecular weight and degree of substitution. Intermolecular multiple hydrogen bonding was identified as the major driving force for cryogel formation.
FOOD HYDROCOLLOIDS
(2022)
Article
Engineering, Biomedical
Zhixiang Cai, Yanmei Tang, Yue Wei, Pengguang Wang, Hongbin Zhang
Summary: In this study, a double-network hydrogel based on hyaluronan and gellan gum was fabricated, which exhibited high compressive strength, high toughness, stiffness, and good self-recovery property. The hydrogel could support chondrocyte proliferation and new extracellular matrix deposition, correlated with its improved mechanical properties, good cytocompatibility, and biodegradability. In vivo experiments in animals demonstrated that this hydrogel facilitated hyaline-like cartilage regeneration. These findings suggest that the developed hydrogel as a biomimetic extracellular matrix offers a hopeful new platform for cartilage tissue engineering.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Applied
Min Wu, Ruiqi Li, Qingyu Liao, Pengguang Wang, Hongbin Zhang
Summary: In order to overcome the challenges of poor solubility and limited functional derivatives in the practical use of curdlan, we synthesized alkylated curdlan with high solubility and thermal responsiveness. The properties of these derivatives were investigated using various analytical techniques. The results showed that the methylated and ethylated curdlan could form reversible heat-set hydrogels with volume shrinkage. The gelation temperatures were influenced by the degree of substitution, size of hydrophobic groups, and the addition of salts.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Yue Wei, Nelson Haotian Lou, Zhixiang Cai, Ruiqi Li, Hongbin Zhang
Summary: This study found that carboxymethylated corn fiber gum (CMCFG) could improve the stability and mouthfeel of pea protein dispersions (PPD), especially in low-viscosity and refreshing PPD. The carboxymethylation reaction enhanced the stabilizing performance of CMCFG, making it a promising stabilizer in pea protein-based beverage formulations.
FOOD HYDROCOLLOIDS
(2022)
Article
Mechanics
Yuanyuan Wei, Ruiqi Li, Hongbin Zhang
Summary: Dysphagia management requires suitable diets, and polysaccharide-thickened food with yielding features is recognized as one such diet. In this study, different rheological approaches were compared to measure the yielding features of polysaccharide-thickened solutions and nutrition emulsions. The results showed that the different methods provided comparable yield stress values. Notably, the stress bifurcation method from LAOS enabled the estimation of yielding onset and end in the solid-liquid transition process, which can offer new insights and innovative ideas for diet design in dysphagia management.
Article
Chemistry, Physical
Yue Wei, Yanping Xie, Zhixiang Cai, Yalong Guo, Min Wu, Pengguang Wang, Ruiqi Li, Hongbin Zhang
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2020)
