Population pharmacokinetics and exposure–response modeling for evinacumab in homozygous familial hypercholesterolemia

Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

(2020) Rene C. Adam et al.   JOURNAL OF LIPID RESEARCH

A randomized study investigating the safety, tolerability, and pharmacokinetics of evinacumab, an ANGPTL3 inhibitor, in healthy Japanese and Caucasian subjects

(2020) Mariko Harada-Shiba et al.   ATHEROSCLEROSIS

LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase

(2020) Liya Wu et al.   CIRCULATION RESEARCH

Evinacumab for Homozygous Familial Hypercholesterolemia

(2020) Frederick J. Raal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Population Pharmacokinetics of Sarilumab in Patients with Rheumatoid Arthritis

(2019) Christine Xu et al.   CLINICAL PHARMACOKINETICS

Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia

(2019) Zahid Ahmad et al.   CIRCULATION

Population Pharmacokinetic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using a Michaelis–Menten Approximation of a Target-Mediated Drug Disposition Model—Support for a Biologics License Application Submission: Part I

(2018) Jean-Marie Martinez et al.   CLINICAL PHARMACOKINETICS

Tutorial on Monoclonal Antibody Pharmacokinetics and its Considerations in Early Development

(2018) Meric Ovacik et al.   CTS-Clinical and Translational Science

Angiopoietin-like 3 in lipoprotein metabolism

(2017) Sander Kersten   Nature Reviews Endocrinology

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

(2017) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom

(2016) Michael France et al.   ATHEROSCLEROSIS

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

(2015) Yan Wang et al.   JOURNAL OF LIPID RESEARCH

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

(2014) M. Cuchel et al.   EUROPEAN HEART JOURNAL

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

(2013) B. G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia

(2010) Kiran Musunuru et al.   NEW ENGLAND JOURNAL OF MEDICINE