Article
Oncology
Siting Cao, Yali Yin, Huijuan Hu, Shubin Hong, Weiman He, Weiming Lv, Rengyun Liu, Yanbing Li, Shuang Yu, Haipeng Xiao
Summary: This study investigated the role of circRNA in thyroid carcinoma and identified circGLIS3 as a novel tumor suppressor in thyroid cancer. CircGLIS3 was found to inhibit the migration and invasion of thyroid carcinoma cells and suppress the progression of thyroid cancer by upregulating the expression of the AIF1L gene through acting as a miR-146b-3p sponge.
Article
Endocrinology & Metabolism
Xin Xie, Ning Zhang, Hongchao He, Xiaojing Wang, Wenbin Rui, Danfeng Xu, Wei He, Yu Zhu
Summary: DDR1a promotes invasion and metastasis in bladder cancer by regulating the ZEB1/COL4 axis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, Research & Experimental
Liang Chen, Wencheng Li, Zhiqin Li, Yarong Song, Jun Zhao, Zhaohui Chen, Gallina Kazobinka, Lulu Li, Yifei Xing, Teng Hou
Summary: The study identified circNUDT21 as an oncogenic circular RNA that promotes bladder cancer progression through the miR-16-1-3p/MDM2/p53 axis. This suggests circNUDT21 as a potential therapeutic target for bladder cancer. CircNUDT21 regulates the proliferative and invasive abilities of bladder cancer cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Shuo Tan, Ye Kang, Hu Li, Hai-Qing He, Long Zheng, Shui-Qing Wu, Kai Ai, Lei Zhang, Ran Xu, Xuan-Zhi Zhang, Xiao-Kun Zhao, Xuan Zhu
Summary: Bladder cancer is an aggressive malignancy with high recurrence rates and distant metastasis, and circular RNAs (circRNAs) play important regulatory roles in cancer progression. In this study, circST6GALNAC6 was identified as downregulated in bladder cancer tissues and cells, inhibiting cell proliferation, migration, invasion, and epithelial-mesenchymal transition both in vitro and in vivo by sponging miR-200a-3p to regulate STMN1 expression. This SP1-induced circST6GALNAC6/miR-200a-3p/STMN1 axis provides potential prognostic biomarkers and therapeutic targets for bladder cancer metastasis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li, Ying Wang
Summary: The study identified that LINC00662 is overexpressed in breast cancer and promotes cancer cell progression by competitively binding to miR-144-3p to upregulate SOX2 expression. This suggests that LINC00662 could be a potential therapeutic target for breast cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Xiaqiong Mao, Tao Ji, Aiguo Liu, Yunqi Weng
Summary: The study revealed that lncRNA SNHG22 is significantly upregulated in gastric cancer tissues and cells, promoting the proliferation and invasion of gastric cancer cells through multiple mechanisms. SNHG22 can be induced by ELK4 and binds EZH2 to suppress tumor suppressor gene expression, while also interacting with miR-200c-3p to increase Notch1 expression. The findings suggest SNHG22 as a potential biomarker for diagnosis and prognosis, as well as a target for gastric cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Wei Zhang, Ting Liu, Tianshu Li, Xudong Zhao
Summary: The study demonstrated that the circular RNA circ_102002 is upregulated in papillary thyroid cancer tissues and cells, promoting cell migration and epithelial-mesenchymal transition by sponging microRNA-488-3p to downregulate its expression, thereby regulating the expression of hyaluronic acid synthetase 2. These findings may provide insights into the pathogenesis of papillary thyroid cancer and potential for clinical treatment.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Haixu Xu, Jie Zhao, Jinping Li, Zhifeng Zhu, Zhaohai Cui, Ran Liu, Rong Lu, Zhi Yao, Qiong Xu
Summary: This study identifies a novel mechanism in which CAF-derived chemokine CCL5 enhances the metastasis and invasion of HCC through the HIF1 alpha/ZEB1 axis. This finding may have implications for the prognosis of HCC and provides a new therapeutic target for HCC.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Huan Feng, Zhiyao Deng, Wei Peng, Xian Wei, Jihong Liu, Tao Wang
Summary: A circular RNA called circEPHA3 was found to be down-regulated in prostate cancer tissues and cell lines. The study further demonstrated that circEPHA3 inhibits the proliferation and metastasis of prostate cancer cells through the miR-513a-3p/BMP2 axis, suggesting its potential as a therapeutic target for prostate cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Lei Jiang, Yan Chen, Guangtao Min, Jun Wang, Wei Chen, Hongpeng Wang, Xiangwen Wang, Nan Yao
Summary: BAG4 has been found to be overexpressed in gastric cancer tissues compared to normal tissues, and its elevated expression is associated with advanced tumor characteristics and poor patient outcomes. Mechanistically, BAG4 promotes invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappa B/ZEB1 axis to induce epithelial-mesenchymal transition.
Article
Biochemistry & Molecular Biology
Wei Li, Yufeng He, Wei Chen, Wenling Man, Qiang Fu, Hongtong Tan, Huanqing Guo, Jingnan Zhou, Po Yang
Summary: LINC00467 is upregulated in HCC and promotes proliferation and invasion, inhibits apoptosis, and contributes to Axitinib resistance through the miR-509-3p/PDGFRA pathway.
Article
Biochemical Research Methods
Wei Feng, Ruixia Guo, Dongya Zhang, Ruitao Zhang
Summary: Our study indicates that depletion of circ-ABCB10 inhibits proliferation, invasion, and EMT, promotes apoptosis of cervical cancer cells through the miR-128-3p/ZEB1 axis, and represses CC tumor growth.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Cell Biology
Jiazhu Sun, Xueyou Ma, Yufan Ying, Weiyu Wang, Haixiang Shen, Song Wang, Haiyun Xie, Jiahe Yi, Weitao Zhan, Jiangfeng Li, Ben Liu
Summary: MicroRNA miR-5581-3p acts as a tumor suppressor in bladder cancer by downregulating SMAD3 and FTO expression, leading to inhibition of migration and proliferation.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Haixiang Shen, Yufan Ying, Xueyou Ma, Haiyun Xie, Shiming Chen, Jiazhu Sun, Zixiang Liu, Chao Wen, Zitong Yang, Xiao Wang, Mingjie Xu, Jindan Luo, Ben Liu, Jiangfeng Li, Xiangyi Zheng, Liping Xie
Summary: This study discovered that FTO is upregulated in clear cell renal cell carcinoma (ccRCC) and promotes tumor growth and migration through the m(6)A/YTHDF2/PDK1 pathway.
CELL DEATH DISCOVERY
(2022)
