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Pharmacology & Pharmacy
Yuan-Yuan Luo, Ke-Gong Tao, Yi-Ting Lu, Bin-Bin Li, Kai-Ming Wu, Chen-Hong Ding, Fang-Zhi Yan, Yue Liu, Yong Lin, Xin Zhang, Xin Zeng
Summary: This study identified hsa_circ_0098181 as a potential therapeutic target for hepatocellular carcinoma (HCC). The downregulation of hsa_circ_0098181 was associated with poor prognosis in HCC patients. Hsa_circ_0098181 sponge miR-18a-3p to regulate PPARA, inhibiting the proliferation, invasion, migration, and colony formation of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chao Li, Juanjuan Cai, Weifeng Liu, Zhenzhen Gao, Guogang Li
Summary: circ-STK39 expression is upregulated in pancreatic cancer tissues and cells, indicating its potential role in pancreatic cancer progression. Downregulation of circ-STK39 inhibits proliferation and migration of pancreatic cancer. Furthermore, TRAM2 and miR-140-3p are identified as downstream targets of circ-STK39, and TRAM2 overexpression reverses the effects of miR-140-3p on migration, proliferation, and epithelial-mesenchymal transition (EMT) in pancreatic cancer.
Article
Cell Biology
Feng Ying Zhang, Xia Li, Ting Ting Huang, Mei Ling Xiang, Lin Lin Sun, Zhao Lan Sun
Summary: LINC00839 is highly expressed in nasopharyngeal carcinoma (NPC), and its attenuation can reduce the aggressive properties of NPC cells by directly sponging miR-454-3p and regulating c-Met expression.
Article
Multidisciplinary Sciences
Ming Zhang, Jieyan Zhou, Yingwen Ji, Shenyou Shu, Mingjun Zhang, Yan Liang
Summary: This study demonstrates the regulatory role of long non-coding RNA (lncRNA) in the formation of cleft palate (CP). It was found that LncRNA-NONMMUT100923.1 regulates the expression of Cdsn gene by competitively binding to endogenous miR-200a-3p, thereby affecting the proliferation and adhesion of embryonic palatal shelf epithelial cells. These findings provide insights into the regulatory role of lncRNA and offer a potential direction for target gene therapy of cleft palate.
Article
Biotechnology & Applied Microbiology
Peilin Zhong, Aihua Guo, Linhua Wang, Xiurong Lin, Mei Feng
Summary: This study aimed to investigate the effect of circRNA CDK6 (circCDK6) on the development and biological behavior of cervical cancer. The results showed that circCDK6 expression level significantly increased in various cervical cancer cells. MiR-449a was identified as a potential target of circCDK6, and silencing circCDK6 led to increased expression of miR-449a. CircCDK6 participated in tumorigenesis and cancer progression and potentially functioned as a tumor suppressor in cervical cell progression through the Epithelial-Mesenchymal Transition (EMT) process by regulating miR-449a.
Article
Cell Biology
Feifan Wang, Yan Zhang, Xuejian Zhou, Xianwu Chen, Jiayong Xiang, Mengjing Fan, Yanlan Yu, Yueshu Cai, Hongshen Wu, Shihan Huang, Ning He, Zhenghui Hu, Guoqing Ding, Xiaodong Jin
Summary: The study identified circPPP1CB as playing a role in tumor growth, metastasis, and EMT process in human bladder cancer by interacting with the miR-1307-3p/SMG1 axis. This suggests circPPP1CB may serve as a novel therapeutic target and diagnostic biomarker for human BC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Pathology
Senmao Li, Yan Wang, Qunduo Cao, Hang Li, Zhengping Zhao, Benling Wei, Haichao Yuan, Zebo Chen, Shangqi Yang
Summary: GLIDR enhances the invasive potential, epithelial-to-mesenchymal transition (EMT), and proliferation of prostate cancer cells by sponging miR-128-3p. These findings suggest that GLIDR may serve as a potential therapeutic target for prostate cancer treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Yang Xia, Wei-Cheng Wang, Wen-Hao Shen, Kun Xu, Yang-Yang Hu, Gao-Hua Han, Yong-Biao Liu
Summary: This study demonstrated that thalidomide inhibits NSCLC angiogenesis and immune evasion by targeting FGD5-AS1. FGD5-AS1 regulates the expression of PD-L1 and VEGFA through the miR-454-3p/ZEB1 axis, affecting the PD-1/PD-L1 checkpoint and exerting anti-tumor effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Li Liu, Zhirui Yu, Qinmei Ma, Jialin Yu, Zhaoqian Gong, Guangcun Deng, Xiaoling Wu
Summary: Emerging evidence suggests that LncRNA NR_003508 contributes to Mtb-induced programmed necrosis by sponging miR-346-3p and regulating RIPK1. BCG infection increases the expression of LncRNA NR_003508, and its knockdown inhibits BCG/H37Rv-induced programmed necrosis in vitro and in vivo. Furthermore, RIPK1 expression is elevated in the peripheral blood of TB patients, and knockdown of LncRNA NR_003508 or overexpression of miR-346-3p suppresses cell necrosis rate and ROS accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Yongbin Chi, Wenlong Zheng, Guangyu Bao, Lifeng Wu, Xiaoxue He, Ruyi Gan, Yan Shen, Xudong Yin, Mingming Jin
Summary: A novel circular RNA, hsa_circ_103820, was identified in lung cancer, showing potential tumor suppressive function by inhibiting proliferation, migration, and invasion of cancer cells. The mechanism involves the direct targeting of miR-200b-3p by hsa_circ_103820 and the regulation of downstream target genes LATS2 and SOCS6.
CELL DEATH & DISEASE
(2021)
Article
Toxicology
Jinmao Liao, Zheng Zhang, Qi Yuan, Qiong Liu, Jia Kuang, Yuan Fang, Xiaoxuan Hu
Summary: The study identified a lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis that regulates HSC activation and may have an impact on the pathogenesis of liver fibrosis. The silencing of Gpr137b-ps or CXCL14 alone improved fibrotic changes induced by CCl4 in mice liver tissue and HSCs in vivo and in vitro. MiR-200a-3p directly targeted Gpr137b-ps and CXCL14, indicating their role in mediating hepatic fibrosis.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Siyeon Jang, Hyeonjin Lee, Seung-Hoon Yang, Beom Seok Kwak, Sun Jung Kim
Summary: This study identifies the role of the ELOVL2-AS1/ELOVL2/miR-1233-3p signaling pathway in drug resistance in Tam-resistant breast cancer, suggesting its potential as a target for therapy.
Article
Cell Biology
Qi Xu, Demin Cheng, Yi Liu, Honghong Pan, Guanru Li, Ping Li, Yan Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: The dysregulation of non-coding RNAs, particularly lncRNA-ATB and its downstream targets miR-29b-2-5p and miR-34c-3p, plays a crucial role in regulating EMT and fibrosis in pulmonary diseases. Overexpression of miR-29b-2-5p or miR-34c-3p can inhibit EMT progression and counteract the pro-fibrotic effects of lncRNA-ATB, providing potential therapeutic targets for pulmonary fibrosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)