Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review
出版年份 2021 全文链接
标题
Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review
作者
关键词
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出版物
Pharmaceuticals
Volume 14, Issue 12, Pages 1316
出版商
MDPI AG
发表日期
2021-12-20
DOI
10.3390/ph14121316
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?
- (2021) Piotr Schulz et al. Nutrients
- Diet-induced obesity in animal models: points to consider and influence on metabolic markers
- (2021) Mariana de Moura e Dias et al. Diabetology & Metabolic Syndrome
- The genetics of obesity: from discovery to biology
- (2021) Ruth J. F. Loos et al. NATURE REVIEWS GENETICS
- Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase
- (2020) Carlo Cifani et al. Frontiers in Pharmacology
- Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity
- (2020) Tina K. Thethi et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- The association of dietary patterns with endocannabinoids levels in overweight and obese women
- (2020) Neda Lotfi Yagin et al. Lipids in Health and Disease
- Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs
- (2020) Thomas Murphy et al. Biomolecules
- The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study
- (2020) Mark E. Schmidt et al. NEUROPSYCHOPHARMACOLOGY
- Understanding the possible role of endocannabinoid system in obesity
- (2020) Tapan Behl et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption
- (2019) Matteo Tardelli et al. JOURNAL OF LIPID RESEARCH
- The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility
- (2019) Neda Lotfi Yagin et al. MOLECULAR BIOLOGY REPORTS
- Glucose Increase DAGLα Levels in Tanycytes and Its Inhibition Alters Orexigenic and Anorexigenic Neuropeptides Expression in Response to Glucose
- (2019) Alejandra Palma-Chavez et al. Frontiers in Endocrinology
- D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction
- (2019) Esmaeil Mansouri et al. NEUROPSYCHOPHARMACOLOGY
- N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis
- (2019) Trisha J. Grevengoed et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced endocannabinoid tone as a potential target of pharmacotherapy
- (2018) Marek Toczek et al. LIFE SCIENCES
- Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance
- (2018) Georgia Balsevich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor–deficient mice
- (2018) Kenji Yoshida et al. FASEB JOURNAL
- Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans
- (2018) Shahar Azar et al. OBESITY SURGERY
- Oleoylethanolamide: A novel pharmaceutical agent in the management of obesity‐an updated review
- (2018) Payahoo Laleh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
- (2017) Leandra Abarca-Gómez et al. LANCET
- Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective
- (2017) Ziva D Cooper et al. NEUROPSYCHOPHARMACOLOGY
- An Introduction to the Endogenous Cannabinoid System
- (2016) Hui-Chen Lu et al. BIOLOGICAL PSYCHIATRY
- Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis
- (2016) Edward J. Wagner FRONTIERS IN NEUROENDOCRINOLOGY
- Economic Impact of Obesity
- (2016) Elena A. Spieker et al. PRIMARY CARE
- Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
- (2015) John D. Douglass et al. JOURNAL OF LIPID RESEARCH
- Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
- (2015) Lucie Geurts et al. Nature Communications
- Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice
- (2015) David R. Powell et al. Frontiers in Endocrinology
- Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture
- (2015) Cyro José de Moraes Martins et al. PLoS One
- Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients
- (2014) D. A. de Luis et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Rimonabant: an antagonist drug of the endocannabinoid system for the treatment of obesity
- (2014) Carlos E. Leite et al. Pharmacological Reports
- Lack of Association between C385A Functional Polymorphism of the Fatty Acid Amide Hydrolase Gene and Polycystic Ovary Syndrome
- (2013) V. Grolmusz et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet
- (2013) Daniel de Luis et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects
- (2012) Tiziana Bisogno et al. BRITISH JOURNAL OF PHARMACOLOGY
- 2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism
- (2012) Kwang-Mook Jung et al. Cell Metabolism
- Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance
- (2012) D.A. de Luis et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Peripheral Effects of FAAH Deficiency on Fuel and Energy Homeostasis: Role of Dysregulated Lysine Acetylation
- (2012) Bhavapriya Vaitheesvaran et al. PLoS One
- Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity
- (2012) Isabelle Matias et al. PLoS One
- Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity
- (2012) Su-Hyoun Chon et al. PLoS One
- Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
- (2012) W. H. Brown et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A fast collapsed data method for estimating haplotype frequencies from pooled genotype data with applications to the study of rare variants
- (2012) Anthony Y.C. Kuk et al. STATISTICS IN MEDICINE
- The Fatty Acid Amide Hydrolase (FAAH) Gene Variant rs324420 AA/AC is not Associated with Weight Loss in a 1-Year Lifestyle Intervention for Obese Children and Adolescents
- (2011) N. Knoll et al. HORMONE AND METABOLIC RESEARCH
- Psychopharmacology of the endocannabinoids: far beyond anandamide
- (2011) FA Pamplona et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity
- (2011) M. I. Vazquez-Roque et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
- (2010) Timo D Müller et al. BMC Medical Genetics
- C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2
- (2010) D.A. de Luis et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- C358A missense polymorphism of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese females
- (2010) D A de Luis et al. INTERNATIONAL JOURNAL OF OBESITY
- An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity
- (2010) F. D. Christopoulou et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide hydrolase on weight loss, adipocytokines, and insulin resistance after 2 hypocaloric diets
- (2010) Daniel Antonio Deluis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet
- (2010) Daniel Antonio de Luis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery
- (2010) D.A. de Luis et al. Surgery for Obesity and Related Diseases
- A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes
- (2010) Gaurav Bhatia et al. PLoS Computational Biology
- Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level
- (2010) Olivier Harismendy et al. GENOME BIOLOGY
- The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
- (2009) Daphne P Guh et al. BMC PUBLIC HEALTH
- FAAH deficiency promotes energy storage and enhances the motivation for food
- (2009) C Touriño et al. INTERNATIONAL JOURNAL OF OBESITY
- Variants in theCNR1and theFAAHGenes and Adiposity Traits in the Community
- (2009) Wolfgang Lieb et al. Obesity
- Obesity-related dyslipidemia associated withFAAH, independent of insulin response, in multigenerational families of Northern European descent
- (2009) Yi Zhang et al. PHARMACOGENOMICS
- The future of endocannabinoid-oriented clinical research after CB1 antagonists
- (2009) Bernard Le Foll et al. PSYCHOPHARMACOLOGY
- The psychiatric side-effects of rimonabant
- (2009) Fabrício A. Moreira et al. REVISTA BRASILEIRA DE PSIQUIATRIA
- The Fatty Acid Amide Hydrolase (FAAH) Pro129Thr Polymorphism is not Associated with Severe Obesity in Greek Subjects
- (2008) D. Papazoglou et al. HORMONE AND METABOLIC RESEARCH
- Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
- (2008) Michael Benzinou et al. HUMAN MOLECULAR GENETICS
- Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
- (2008) Mauro Maccarrone et al. NATURE NEUROSCIENCE
- Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population
- (2008) Emmanuelle Durand et al. Obesity Facts
- The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women
- (2008) Palmiero Monteleone et al. PSYCHONEUROENDOCRINOLOGY
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