Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease

(2021) Audrey Hector et al.   Frontiers in Molecular Neuroscience

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice

(2021) Daniel R. Gulbranson et al.   eNeuro

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

(2021) Stephanie S. Holden et al.   SCIENCE

Association of epileptiform abnormalities and seizures in Alzheimer disease

(2020) Alice D. Lam et al.   NEUROLOGY

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

(2020) Samuel S. Harris et al.   NEURON

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

(2020) Erik C. B. Johnson et al.   Molecular Neurodegeneration

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease

(2020) Alice D. Lam et al.   Epilepsy Currents

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

(2020) Nicole D. Schartz et al.   Journal of Neuroinflammation

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for Stakeholders

(2019) Youssef H. El-Hayek et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer’s Disease Model

(2019) Chia-Hsuan Fu et al.   Cell Reports

Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine

(2019) Kouichi Itoh et al.   NEUROSCIENCE LETTERS

Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

(2019) Kristie M. Garza et al.   JOURNAL OF NEUROSCIENCE

Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2

(2018) Athena Sudom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS

(2018) Andrea J. Tenner et al.   MOLECULAR IMMUNOLOGY

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy

(2018) Nicole D. Schartz et al.   NEUROBIOLOGY OF DISEASE

Istradefylline reduces memory deficits in aging mice with amyloid pathology

(2018) Anna G. Orr et al.   NEUROBIOLOGY OF DISEASE

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

(2018) Jennifer D. Whitesell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Sleep EEG Detects Epileptiform Activity in Alzheimer’s Disease with High Sensitivity

(2017) András Horváth et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study

(2016) María M. Corrada et al.   Alzheimers & Dementia

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

(2016) Keith A. Vossel et al.   ANNALS OF NEUROLOGY

Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond

(2016) Wolfgang Löscher et al.   CNS DRUGS

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

(2016) Amitabh Das et al.   Journal of Neuroinflammation

Attenuation of  -Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

(2016) P. Yuan et al.   JOURNAL OF NEUROSCIENCE

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

TYROBP genetic variants in early-onset Alzheimer's disease

(2016) Cyril Pottier et al.   NEUROBIOLOGY OF AGING

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?

(2015) Melanie Meyer-Luehmann et al.   TRENDS IN NEUROSCIENCES

Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse model

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease

(2008) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE